Citation: Wang Yang, Ye Hao, Qian Cheng, Yao Wei, Li Hong, Wang Kai, Hu Lanping, Li Ling, Wu Jinming, Dai Hong. Synthesis and Insecticidal Activities of Novel Pyrazole Oxime Ethers Carrying 1, 3, 4-Oxadiazole Unit[J]. Chinese Journal of Organic Chemistry, ;2020, 40(1): 232-238. doi: 10.6023/cjoc201908006 shu

Synthesis and Insecticidal Activities of Novel Pyrazole Oxime Ethers Carrying 1, 3, 4-Oxadiazole Unit

Wang Yang ^a ,
Ye Hao ^a ,
Qian Cheng ^a ,
Yao Wei ^a ,
Li Hong ^b ,
Wang Kai ^a ,
Hu Lanping ^a,, ,
Li Ling ^a ,
Wu Jinming ^a ,
Dai Hong ^a,,

a.
College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019
b.
Nantong Fengtian Chemical Industry Co. Ltd, Nantong 226005

Corresponding author: Hu Lanping, hlp@ntu.edu.cn Dai Hong, daihong_2015@aliyun.com
Received Date: 4 August 2019
Revised Date: 26 August 2019
Available Online: 5 January 2019
Fund Project: the Science and Technology Project Fund of Nantong City MS12019060the Science and Technology Innovation Foundation for the College Students of Jiangsu Province 201810304016ZProject supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12017022-4, MS12019060), and the Science and Technology Innovation Foundation for the College Students of Jiangsu Province (No. 201810304016Z)the Science and Technology Project Fund of Nantong City MS12017022-4the National Natural Science Foundation of China 21372135

Figures(3)

In search of novel pyrazole oxime ether derivatives with potent bioactivities, fifteen new pyrazole oxime ethers were designed and synthesized by introducing 1, 3, 4-oxadiazole moiety into the C-4 position of pyrazole based on the structure of fenpyroximate. Their structures were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. Preliminary bioassay data showed that some title compounds possessed good insecticidal activities against Oriental armyworm or Aphis medicaginis at the concentration of 500 and 100 μg/mL. At 100 μg/mL, compounds 10a, 10e, 10f and 10j displayed 100% mortality rate against Oriental armyworm, and compounds 10g, 10j and 10l showed insecticidal activity against Aphis medicaginis with 100%. In addition, compound 10l had 100% mortality rate against Tetranychus cinnabarinus at 500 μg/mL.
- 1, 3, 4-oxadiazole,
- pyrazole oxime ether,
- synthesis,
- insecticidal activity
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