2006 Volume 17 Issue 3

Synthesis of Obyanamide, a Marine Cytotoxic Cyclic Depsipeptide
Wei ZHANG , Ni SONG , Zhong Zhen LI , Ying Xia LI
2006, 17(3): 285-288
[Abstract](192) [FullText HTML] [PDF 110KB](0)
Abstract:
The synthesis of a marine cytotoxic cyclic depsipeptide obyanamide has been accomplished. The key steps include assembling liner pentapeptide via Yamaguchi esterification and HATU-promoted ring closing. The structure of the synthetic sample was identified by 1H and 13C NMR, H-H COSY, HMQC, HMBC, and HRESIMS, but appears to be different from that of the marine natural product.
Synthesis of Novel Dendrimers Containing Amino Acids and Peptides
Gu HE , Li GUO , Li Fang MA
2006, 17(3): 289-292
[Abstract](182) [FullText HTML] [PDF 133KB](0)
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Some novel peptide dendrimers bearing four amino acids, GD and RGD peptides on their surface were synthesized from tetrakis[(carboxyethoxy)methyl]-methane using DCC method.
The Application of Suzuki Coupling Reaction on the Preparation of Carbosilane Dendrimers with 4-(Naphthalen-1-yl)phenyl Core
Rui Fang GUAN , Chuan Jian ZHOU , Sheng Yu FENG , David J. BERG , Stephen R. STOBART
2006, 17(3): 293-295
[Abstract](329) [FullText HTML] [PDF 101KB](0)
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Carbosilane dendrimers with p-bromophenyl core were synthesized by alternating Grignard and hydrosilylation reaction. And the α-naphthalenyl was connected to the core by the Suzuki coupling reaction. A new carbosilane dendrimer with big π-conjugated structure[4-(naphthalen-1-yl)phenyl core] was given. It shows Suzuki coupling reaction is an effective and powerful core-functionalization method and the satisfactory result can be obtained through prolonging the reaction time with the increase of the generation of dendrimer.
Rhodium-catalyzed Asymmetric Ring Opening Reaction of Oxabenzo-norbornadiene with Substituted Phenolic Nucleophiles
Ying Feng HAN , Ding Qiao YANG , Er Chang LIU , Jian Xia DONG
2006, 17(3): 296-298
[Abstract](186) [FullText HTML] [PDF 112KB](0)
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We have developed an asymmetric ring opening reaction of oxabenzonorbornadienes with substituted phenolic nucleophiles. Under the reaction conditions ([Rh(COD)Cl]2 (1 mol%), (S)-(R)-PPF-ptBu2 (2 mol%), THF, reflux), the reaction products were obtained with high yield and enantiomeric excesses (up to 99% ee).
Organic Synthesis in Ionic Liquids: Condensation of 3-Methyl-1-phenyl-5-pyrazolone with Carbonyl Compounds Catalyzed by Ethylenediammonium Diacetate(EDDA)
Yi HU , Ping WEI , Hua ZHOU , Ping Kai OUYANG , Zhen Chu CHEN
2006, 17(3): 299-301
[Abstract](196) [FullText HTML] [PDF 96KB](5)
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An efficient and environmental benign method is reported for the condensation of 3-methyl-1-phenyl-5-pyrazolone with carbonyl compounds in ionic liquids [Bmim]BF4 and [Bmim]PF6 catalyzed by ethylenediammonium diacetate.
A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide
Guang Yu XU , Yi ZHOU , Man Cai XU
2006, 17(3): 302-304
[Abstract](188) [FullText HTML] [PDF 134KB](0)
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A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH4 and 4Ǻ sieve, followed by hydrolysis and regioselective cyclization.
Synthesis of a New Aromatic Dianhydride Containing Pyridine Ring and Related Polyimide
Xiao Long WANG , Shu Jiang ZHANG , Yan Feng LI , Tao MA , Yu SHAO , Xin ZHAO
2006, 17(3): 305-306
[Abstract](172) [FullText HTML] [PDF 35KB](1)
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A new aromatic dianhydride monomer containing pyridine moiety, 2, 6-bis[4'-(3", 4"dicarboxyphenoxy)benzoyl]-pyridine dianhydride (Md), was synthesized in four steps, starting from 2, 6-pyridinedicarboxyl chloride. A novel pyridine-containing polyimide was prepared via polycondensation of Md with ODA by two-step method. The resulting polyimide exhibits excellent solubility, film-forming capability and high thermal resistance.
Total Synthesis of Three New Dihydrostilbenes from Bulbophllum odoratissimum
Jin Guang LIN , Wei Ge ZHANG , Rui ZHAO , Ze Yu NIU , Kai BAO , Dai Lin LIU , Nai Li WANG , Xin Shen YAO
2006, 17(3): 307-309
[Abstract](264) [FullText HTML] [PDF 63KB](2)
Abstract:
A total synthesis of three new dihydrostilbenes, 1, 2 and 3, which were isolated from Bulbophyllum odoratissimum Lindl. with significant cytotoxicity toward human cancer cell lines, was developed via Horner reaction etc. The natural products 1, 2 and 3 were obtained in 5.8%, 6.6% and 5.9%, respectively.
Synthesis of a New Series of Bone Affinity Compounds
Ying WANG , Hong CHEN , Zong Ming WAN , Mao Sheng CHENG , Xue Chao WANG , Guo Liang CONG , Sheng JING , Zi Ping YAN , Bo WU
2006, 17(3): 310-312
[Abstract](193) [FullText HTML] [PDF 115KB](0)
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A new series of bone affinity compounds were synthesized by linking chrysophanol with 5-fluorouracil derivatives. Their bone affinity was established by hydroxyapafive (HA)affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.
CuI/Proline-catalyzed N-Arylation of Nitrogen Heterocycles
Wei DENG , Ye Feng WANG , Chen ZHANG , Lei LIU , Qing Xiang GUO
2006, 17(3): 313-316
[Abstract](185) [FullText HTML] [PDF 57KB](0)
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Ma's CuI/proline procedure for the catalytic cross coupling between nitrogen heterocycles and aryl halides was markedly improved. The key finding was that K3PO4 was a much better base than K2CO3 for the reaction. With this new reaction condition the cross coupling with aryl iodides could be accomplished in 1, 4-dioxane instead of DMSO. This reactin also could be carried out in DMF. Furthermore, the coupling yields under the new conditions are usually higher than in Ma's original methods.
Synthesis and Structures of New Cyclopalladated Ferrocenylimines
Xue Mei ZHAO , Xin Qi HAO , Bin LIU , Mao Ping SONG , Yang Jie WU
2006, 17(3): 317-320
[Abstract](186) [FullText HTML] [PDF 163KB](0)
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The new complexes, [PdCl{C5H4FeC5H4CHRN=CHC4H3O}(Ph3P)] (R=H, CH3) were synthesized via two novel Schiff bases (C5H5FeC5H4CHRN=CHC4H3O, R=H, CH3) with lithium tetrachloropalladate (Ⅱ), and characterized by IR, elemental analysis, 1H NMR. Complex 5a was further determined by X-ray single crystal diffraction. We found that it contained an intramolecular N→Pd coordination in the compound Sa, and the palladium atom was bound to the unsubstituted Cp ring. The Pd-N, Pd-C (1) and Pd-O bond lengths were 2.121(3), 2.008(4) and 2.990(A), respectively.
One-pot Synthesis of Lewis Acidic Ionic Liquids for Friedel-Crafts Alkylation
Ling HE , Guo Hong TAO , Wei Shan LIU , Wei XIONG , Tao WANG , Yuan KOU
2006, 17(3): 321-324
[Abstract](179) [FullText HTML] [PDF 47KB](0)
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Novel Lewis acidic ionic liquids containing thionyl cations and chloroaluminate anions were obtained by one-pot synthesis for the first time. Their acidities were determined by acetonitrile probe on IR spectrography. The ionic liquids were used as catalyst for Friedel-Crafts alkylation of benzene and 1-dodecene. The turnovers of 1-dodecene were higher than 99%. Monoalkylbenzene selectivity was 98%, while the 2-substituent product selectivity was 45%.
Design, Synthesis and in vitro Evaluation of Thiazole Derivatives of Ibuprofen as Cyclooxygenase-2 Inhibitors
Chang Bin GUO , Zhe Feng CAI , Zong Ru GUO , Zhi Qiang FENG , Feng Ming CHU , Gui Fang CHENG
2006, 17(3): 325-328
[Abstract](206) [FullText HTML] [PDF 83KB](2)
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A series of thiazole derivatives of ibuprofen, as cyclooxygenase-2 Inhibitors, were designed, synthesized and in vitro evaluated.
One-pot Approach to the Conversion of Alcohols into α-Halo-α, β-unsaturated Esters
Gui Sheng DENG , Chun Yu LIU
2006, 17(3): 329-332
[Abstract](181) [FullText HTML] [PDF 43KB](0)
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The sequential oxidation-Horner-Wadsworth-Emmons reaction of alcohols to prepare α-halo-α, β-unsaturated esters (halo=F, Cl) with middle to excellent (Z)-selectivity was developed.
Photoinduced Electron Transfer in Host-Guest Complexes of Naphthalene Derivatives with p-NBCD and m-NBCD
Hui Yuan HU , Man Zhou ZHU , Zhi Ping ZHANG , Guo Tao WEN , Qing Xiang GUO
2006, 17(3): 333-336
[Abstract](294) [FullText HTML] [PDF 163KB](1)
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A number of naphthalene derivatives containing adamantanamine binding moiety and an (CH2)n (n=2, 3, 4, 5, 6) spacer were prepared as electron donor. A supramolecular assembly was fabricated by the inclusion complexation of the donor substrates with the host molecules, mono-6-O-p-nitrobenzoyl-β-cyclodextrin (p-NBCD) and mono-6-O-m-nitrobenzoyl-β-cyclodextrin (m-NBCD), in water. The fluorescence quenching in these systems was studied and detailed Stern-Volmer constants were measured. It revealed that an efficient photoinduced electron transfers (PET) between the naphthalene donors and the cyclodextrin acceptors occurred.
Two New Antibacterial Iridoids from Patrinia rupestris
Xiu Ping YANG , Cheng Shan YUAN , Zhong Jian JIA
2006, 17(3): 337-340
[Abstract](183) [FullText HTML] [PDF 103KB](0)
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Two new iridoids (1 and 2) were isolated from the roots of Patrinia rupestris (Pall.) Juss.Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited strong antibacterial activities against Eschecichia coli and Staphylococcus aureus, respectively.
Two New Oplopanol Esters from Ligularia narynensis
Xue GAO , Tong SHEN , Wei Dong XIE , Zhong Jian JIA
2006, 17(3): 341-343
[Abstract](185) [FullText HTML] [PDF 111KB](1)
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Tow new oplopanol esters were isolated from the roots of Ligularia narynensis. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques.
A New Pyrone Derivative from Fungus Cephalosporium sp. AL031
Yun Mei BI , Xu Bin BI , Qian Rong ZHAO , Fang A , Ye Gao CHEN
2006, 17(3): 344-346
[Abstract](174) [FullText HTML] [PDF 123KB](0)
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A novel pyrone derivative was isolated from the ethyl acetate extract of a culture broth of a strain of the fungus Cephalosporium sp. AL031. Its structure was characterized as 7-hydroxy-9-methoxyl-10-methyl-2H, 4aH, 6H, 10bH-pyrano[5, 6-c][2]benzopyran-2, 6-dione by spectroscopic analysis including IR, MS, 1D and 2D NMR spectra.
Two New Acetyl Cimicifugosides from the Rhizomes of Cimicifuga Racemosa
Chun DAN , Rui WANG , Shu Lin PENG , Bing Ru BAI , Li Sheng DING
2006, 17(3): 347-350
[Abstract](269) [FullText HTML] [PDF 129KB](0)
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Two new acetyl cimicifugosides were isolated from the rhizomes of Cimicifuga racemosa. Their structures were elucidated as 2'-O-acetyl cimicifugoside H-1 1 and 3'-O-acetyl cimicifugoside H-1 2 by the spectroscopic evidence and chemical methods.
Four New Isovalertatins M33, D13, D33, and D43, from the Culture Filtrate of Streptomyces luteogriseus
Duan Yun SI , Da Fang ZHONG , Chang Xiao LIU
2006, 17(3): 351-354
[Abstract](192) [FullText HTML] [PDF 166KB](1)
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Four new aminooligosaccharides, isovalertatins M33 1, D13 2, D33 3, and D43 4, were isolated from the culture filtrate of Streptomyces luteogriseus. Their structures were established by chemical and spectroscopic evidences including ESI multistage mass spectrometry and 2-dimensional NMR techniques, and were found in full consistencies with the previous profiling results proposed by LC/ESI/MS analysis.
A Novel Sesquiterpenoid from Glechoma longituba
Qian Jun ZHANG , Xiao Sheng YANG , Hai Yan ZHU , Ye WANG , Xiao Jiang HAO , Bao An SONG
2006, 17(3): 355-357
[Abstract](181) [FullText HTML] [PDF 150KB](0)
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A novel sesquiterpenoid was isolated from the whole plant of Glechoma longituba. Its structure was elucidated as 1, 8-epoxy-7(11)-germacren-5-one-12, 8-olide 1 on the basis of spectral evidences.
Highly Selective Diphoshinoamine/Cr(Ⅲ) Catalysts for Ethylene Tetramerization
Tao JIANG , Hong Xia CHEN , Ying Nan NING , Wei CHEN
2006, 17(3): 358-360
[Abstract](190) [FullText HTML] [PDF 111KB](1)
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Two novel diphoshinoamine ligands have been synthesized. Combination of Cr(Ⅲ) and methylaluminoxane(MAO) generated active catalytic system which can catalyze tetramerization of ethylene with high catalytic activity up to 2.5×10-6g/mol Cr.h and high selectivity to produce 1-octene (C8 in products is being 89.80 wt%).
Microwave-assisted Preparation of Temperature Sensitive Poly(N-isopropylacrylamide) Hydrogel with Improved Responsive Properties
Shao Hua SHI , Li Jian LIU
2006, 17(3): 361-364
[Abstract](187) [FullText HTML] [PDF 62KB](0)
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Poly(N-isopropylacrylamide)-based hydrogel was prepared under microwave irradiation.The hydrogel thus prepared, comparing with that prepared by thermal heating method, exhibits faster swelling and shrinking kinetics. The improved responsive properties are due to the more heterogeneous and porous networks formed under microwave irradiation.
Synthesis and Characterization of the Polyacrylonitrile-block-poly(methyl acrylate) by RAFT Technique
Quan Fu AN , Jin Wen QIAN , Cong Jie GAO
2006, 17(3): 365-368
[Abstract](178) [FullText HTML] [PDF 161KB](0)
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Polyacrylonitrile-block-poly(methyl acrylate)(P(AN-b-MA)) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization employing macro-RAFT agent (PAN-RAFT) as the chain transfer agent and azobis(isobutyronitrile) (AIBN) as the initiator.A linear relationship between ln([M]0/[M]t) and reaction time was observed. The molecular structure of P(AN-b-MA) was characterized by 1H-NMR, element analysis, FTIR and SEC. The molecular weight distribution (MWD) was less than 1.40, the Mn could be controled from 0.733 to 4.834×104, and the molar content of MA in P(AN-b-MA) were from 15.6 to 75.0 percentage, respectively.
Synthesis of a Novel UV Curable Aqueous Dispersion Polyurethane PDHA-PEDA-PU and the Properties of Cured Film
Chen Yan BAI , Xing Yuan ZHANG , Jia Bing DAI , Wei Hu LI
2006, 17(3): 369-372
[Abstract](187) [FullText HTML] [PDF 100KB](0)
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A novel ultraviolet (UV) curable aqueous dispersion polyurethane PDHA-PEDA-PU was synthesized based on isophorone diisocyanate (IPDI), polyester dihydric alcohol (PDHA), dimethylol propionic acid (DMPA), pentaerythritol diacrylate (PEDA), 2-hydroxyethyl acrylate (HEA) and triethylamine (TEA). Acrylate groups were incorporated in the side and end of PDHA-PEDA-PU chain. The C=C content in the chain can be controlled easily through the change of IPDI/PDHA/PEDA ratio. Fourier transform infrared spectroscopy (FTIR) was used to identify the structure of prepolymer, aqueous dispersion and cured polyurethane. The curing rule of the polyurethane for different C=C content has been investigated depending on the change of C=C content during the curing process. The hardness, thermal stability and scrub resistance to MEK of UV cured PDHA-PEDA-PU were also discussed for the samples with different C=C content.
Synthesis of Highly Branched Poly(ε-caprolactone) by Self-condensing Atom Transfer Radical Polymerization of Macroinimers
Rui Xue LIU , Yan SHI , Zhi Feng FU , Shu Ke JIAO
2006, 17(3): 373-376
[Abstract](190) [FullText HTML] [PDF 183KB](0)
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Branched poly(ε-caprolactone) was synthesized by self-condensing atom transfer radical polymerization of macroinimer, α-acryloyoxy-ω-2-bromopropionyloxy poly(ε-caprolactone), which was prepared by enzyme-catalyzed ring-opening polymerization of ε-caprolactone with 2-hydroxylethyl acrylate as initiator and esterification of the ω-hydroxyl group of the obtained poly(ε-caprolactone) by 2-bromopropionyl bromide.
Colorimetric Detection of Aniline Based on Di(hydroxymethyl)-di-(2-pyrrolyl)methane-TCNQ System
Jian XU , Yong GUO , Shi Jun SHAO
2006, 17(3): 377-379
[Abstract](198) [FullText HTML] [PDF 106KB](1)
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The blue color system of supramolecular assembly formed by di(hydroxymethyl)di-(2-pyrrolyl)methane and tetracyanoquinodimethane (TCNQ) may be used for effective and selective detection of aniline through the visual color change in CH3CN/H2O mixed solvent. The excellent properties of the system make the supramolecular assembly to be a highly selective colorimetric probe for aniline.
Fourier Self-deconvolution Using Approximation Obtained from Frequency Domain Wavelet Transform as a Linear Function
Yuan Zhen ZHOU , Jian Bin ZHENG
2006, 17(3): 380-382
[Abstract](189) [FullText HTML] [PDF 47KB](0)
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A new method of resolving overlapped peak, Fourier self-deconvolution (FSD) using approximation CN obtained from frequency domain wavelet transform of F(ω) yielded by Fourier transform of overlapped peak signals f(t) as the linear function, was presented in this paper.Compared with classical FSD, the new method exhibits excellent resolution for different overlapped peak signals such as HPLC signals, and have some characteristics such as an extensive applicability for any overlapped peak shape signals and a simple operation because of no selection procedure of the linear function. Its excellent resolution for those different overlapped peak signals is mainly because F(ω) obtained from Fourier transform of f(t) and CN obtained from wavelet transform of F(ω) have the similar linearity and peak width. The effect of those fake peaks can be eliminated by the algorithm proposed by authors. This method has good potential in the process of different overlapped peak signals.
Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules
Juan Fang WU , Ling Xin CHEN , Guo An LUO , Yong Suo LIU , Yi Ming WANG , Zhi Hong JIANG
2006, 17(3): 383-386
[Abstract](186) [FullText HTML] [PDF 149KB](1)
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Two 17-mer dsDNA with different sequence characteristics were designed to investigate the binding characteristics of berberine, an anticancer drug with uncertain binding mode, and Hoechst 33258, a model DNA minor groove binder, with dsDNA, respectively by the capillary zone electrophoresis (CZE). Kenndler model analysis revealed that Hoechst 33258 exhibited intermediate affinity with dsDNA, while there was only low affinity and some weak binding preference for AATT-containing to GGCC-containing dsDNA for berberine.
New Subsidiary Interaction Mode of Counteranions with the Periphery Cavity of Calix[4]pyrroles Binding with the Anion Subunits
Kai LIU , Yong GUO , Jian XU , Shi Jun SHAO , Sheng Xiang JIANG
2006, 17(3): 387-390
[Abstract](186) [FullText HTML] [PDF 113KB](0)
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The solution binding properties of calix[4]pyrroles with anion (as tetraalkylammonium salts) were investigated using UV-Vis spectroscopic techniques. The obvious red-shift of absorption maximum band of calix[4]pyrrole in EtOH in the presence of the tetramethylammonium (TMA+) salts or tetraethylammonium (TEA+) salts were observed, due to the charge-transfer interactions between the electron-rich pyrrole rings of calix[4]pyrroles and TMA+ or TEA+ cation subunit. The results indicated that calix[4]pyrrole receptors, which link the anionic species through multiple hydrogen bonding interactions, can use the periphery cavity for selectively binding cation subunits by cation-π charge-transfer interaction. The subsidiary interaction mode helps to further stabilize the calix[4]pyrrole-anion complex.
The Study on the Noncovalent Complexes of Silver Ion with Xanthone Diglycosides by Electrospray Ionization with Tandem Mass Spectrometry
Yan Guo SUN , Xi ZHANG , Hong Bin XIAO , Xin Miao LIANG
2006, 17(3): 391-394
[Abstract](195) [FullText HTML] [PDF 130KB](0)
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The silver ionic complexes of xanthone glycosides were studied by ESI-MS/MS in the positive ion mode. The fragmentation pathways of silver ionic complexes under collisioninduced dissociation (CID) were investigated and the differences in MS/MS spectra of different silver ionic complexes of xanthones were correlated to the characterization of saccharide and the coordination pattern of silver ion with xanthones, including the glycosilation position and linkage type of disaccharide (1-2 and 1-6 linkages).
A Novel Method for Diminishing Protein Aggregation during Denatuaration Process
Ye Hua SHEN , Quan BAI , Yang Jun ZHANG , Yin Mao WEI , Hai Bo WANG , Xing Du GENG
2006, 17(3): 395-398
[Abstract](179) [FullText HTML] [PDF 129KB](0)
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The addition of packing material for high performance hydrophobic interaction chrornatograghy (HPHIC) into the denaturant solution to prevent, or depress protein aggregation in the denatuaration process is presented. The renaturation of α-chymotrypsin (α-Chy)denatured with guanidine hydrochloride (GuHCl) solution indicated that renaturation efficiency can be enhanced from 36.1% to 59.0% by this new method. The structure of the ligand linking of HPHIC packings is also important for the protein renaturation.
A pH-sensitive Modified Polyacrylamide Hydrogel
Ping An SONG , Ya Feng ZHANG , Jian Zheng KUANG
2006, 17(3): 399-402
[Abstract](179) [FullText HTML] [PDF 262KB](0)
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A pH-sensitive modified polyacrylamide hydrogel was prepared by two steps and the modified polyacrylamide was characterized by 1HNMR spectrum. The surface morphology and swelling behavior of the hydrogels were investigated.
Temperature-pH Sensitive IPN Hydrogels Composed of Silk Sericin and Poly (N-isopropylacrylamide)
Wen WU , Wen Jing LI , Li Qun WANG , Ke Hua TU , Wei Lin SUN
2006, 17(3): 403-406
[Abstract](179) [FullText HTML] [PDF 186KB](1)
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Interpenetrating polymer network (IPN) composed of silk sericin (SS) and poly(N-isopropylacrylamide) (PNIPAAm) was prepared. The morphology of the IPNs, in which the SS phase was stained with ammonium cuprate, was examined with TEM and a relative homogeneous distribution of the two polymers was exhibited. The swelling behavior of the IPN hydrogels showed both temperature and pH dependences.
6-O-(Hydroxypropyltrimethylammonia)-β-cyclodextrin with Low Degree of Substitution: Convenient Preparation and its Application as a Chiral Selector in Capillary Electrophoresis
Ming Gang ZHAO , Ai You HAO , Jian LI , Xiu Li LIN
2006, 17(3): 407-410
[Abstract](443) [FullText HTML] [PDF 128KB](1)
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A cationic cyclodextrin derivative 6-O-(hydroxypropyltrimethylammonia)-β-cyclodextrin (GTA-β-CD) with low degree of substitution was prepared through a convenient method in solid phase. The product could be used as a valuable chiral selector in the capillary electrophoresis (CE) separation of some acidic drug enantiomers such as naproxen, ofloxacin, ibuprofen and warfarin.
Synthesis and Characterization of Novel Orange-emitting Iridium(Ⅲ) Complexes with Diphenylquinoline Ligands Containing Fluorinated Substituent
Xiao Wei ZHANG , Chu Luo YANG , Zhong An LI , Lin Na ZHU , Jin Gui QIN , Jia GAO , Dong Ge MA
2006, 17(3): 411-414
[Abstract](173) [FullText HTML] [PDF 142KB](0)
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Three new cyclometalated iridium(Ⅲ) complexes based on ligands of diphenylquinoline with fluorinated substituents were prepared, and characterized by elemental analysis (EA), 1H NMR, and mass spectroscopy (MS). The photophysical and electrophosphorescent properties of the complexes were briefly discussed.
Destabilization of Basic Fibroblast Growth Factor by Oligodeoxynucleotides
Qiang WU , Ju WANG , Ling ZHANG , An HONG , Jin Song REN
2006, 17(3): 415-418
[Abstract](168) [FullText HTML] [PDF 163KB](0)
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The effects of oligodeoxynucleotide (ODN) on the conformation of basic fibroblast growth factor (bFGF) were studied by spectral method. The results showed that ODN destabilized the protein.
Copper Tetrahydrosalen Complex Encapsulated in Zeolite Y:an Effective Heterogeneous Catalyst for the Oxidation of Cycloalkanes
Chun JIN , Yin Juan JIA , Bin Bin FAN , Jing Hong MA , Rui Feng LI
2006, 17(3): 419-422
[Abstract](185) [FullText HTML] [PDF 65KB](0)
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A new heterogeneous catalyst, copper tetrahydrosalen complex encapsulated in zeolite Y (denoted as Cu[H4]salen/Y) has been developed with flexible ligand method, and characterized by FTIR, DR UV-Vis spectroscopy, N2 adsorption/desorption at -196℃. This catalyst behaved like a bio-mimic enzyme, and exhibited much higher activity for the oxidation of cycloalkanes than Cusalen/Y prepared with the same method. The effects of the reaction conditions on the catalytic performance were investigated.
Theoretical Study on the Addition Reactions of Benzaldoximes with Propene
Guo Ping LI , Wei Ren XU , Xian Jie LIN , Cheng Bu LIU
2006, 17(3): 423-426
[Abstract](286) [FullText HTML] [PDF 119KB](0)
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The Michael addition reactions of Z and E benzaldoximes with propene were investigated theoretically by DFT method at B3LYP/6-31G* level. The calculation results show that both addition reactions are concerted processes accompanied by the migration of hydrogen from the atom oxygen to carbon. Both products Z and E nitrones have dipolar charge distributions and activities. Z isomer is more favorable in the reaction due to the barrier is lower.
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