Citation: Guang Yu XU, Yi ZHOU, Man Cai XU. A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide[J]. Chinese Chemical Letters, ;2006, 17(3): 302-304. shu

A Convenient Synthesis of Antibacterial Linezolid from (S)-Glyceraldehyde Acetonide

College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081

Received Date: 18 July 2005

Fund Project: We thank Hunan Province Department of Education (Grant No. 05C403) for financial support.

A convenient synthesis of oxazolidinone antibacterial linezolid from readily available L-ascorbic acid is described. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH₄ and 4Ǻ sieve, followed by hydrolysis and regioselective cyclization.
- Linezolid,
- antibacterial,
- synthesis,
- ascorbic acid
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