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Preface to Crystalline Porous Materials
Jiandong Pang, Ning Huang, Shuai Yuan, Jun-Sheng Qin
2022, 41(11): 2211001-2211002  doi: 10.14102/j.cnki.0254-5861.2022-0211
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Review
Lithium Ion Conduction in Covalent Organic Frameworks
Sijia Liu, Minghao Liu, Qing Xu, Gaofeng Zeng
2022, 41(11): 2211003-2211017  doi: 10.14102/j.cnki.0254-5861.2022-0114
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Ion conduction plays key roles in electrochemical systems, including fuel cells, lithium ion batteries, and metal-air batteries. Covalent organic frameworks (COFs), as a new class of porous polymers, constructed by pre-designable building blocks, are ideal hosts to accommodate ionic carries for conduction because of their straightforward pore channels, tunable pore size, controllable pore environment, and good chemical and thermal stability. Different from proton conduction, how to achieve high lithium ion conduction is still a challenge as it is difficult to dissociate ionic bonds of the lithium salts. To facilitate the dissociation of lithium salts, COFs with different pores and skeletons are well designed and constructed. This review focuses on emerging developments of lithium ion conduction in COFs, and discusses the structures of these COFs and conductive performance to elucidate the structure-property correlations. Furthermore, we have concluded the remaining challenge and future direction in these COF-based lithium conductive areas. This review provides deeper insight into COFs for ionic conduction.
A Review on the Progress of Metal-Organic Frameworks in Electrochemiluminescence Sensors
Huiping Sun, Zuoxi Li, Yu Gu, Chunxian Guo
2022, 41(11): 2211018-2211030  doi: 10.14102/j.cnki.0254-5861.2022-0126
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Electrochemiluminescence (ECL) is a powerful technology that is the triple point of chemical, electronic, and optical technologies. The ECL-based sensors attract enormous attention due to the unifying of the advantages of electrochemical and optical sensors. The development of ultrasensitive, rapid, highly specific, and cost-effective ECL sensors for detecting substances with human health and life is critical. Metal-organic frameworks (MOFs) is a kind of molecular crystalline material regarded as a promising candidate for application in ECL sensors after its great improvement because of the improved MOFs with particular merits such as large surface area, tunable pore scale, structural diversity, superior conductivity, water stability, low toxicity, and good biocompatibility. In this review, we emphasize discussing the applications of MOFs for ECL sensing detection of varying targets that are related to human health and life, such as metal ions, small molecules, nucleic acids, proteins, bacteria, and viruses. Then, the relationship between ECL performance and MOFs characters is sprinkled in the discussion of the representative example. Finally, we provide the potential opportunities and challenges faced by MOFs in the realm of ECL sensors, as well as the future perspectives.
Recent Advances in C2 Gases Separation and Purification by Metal-Organic Frameworks
Zhengyi Di, Xinjing Zheng, Yu Qi, Heng Yuan, Cheng-Peng Li
2022, 41(11): 2211031-2211044  doi: 10.14102/j.cnki.0254-5861.2022-0132
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Separation of C2 gases (C2H2/C2H4, C2H6/C2H4 and C2H2/CO2) mixtures is one of the most important and energy-demanding processes in chemical industry. Traditional separation methods (fine distillation separation and selective catalytic hydrogenation separation) have the shortages of high energy consumption and inefficient use of resources, affecting the achievement of peak carbon dioxide emissions and carbon neutrality targets. Separation based on adsorption is considered as one of the best ways to achieve low-energy separations. Therefore, it is of great importance to synthesize materials that enable the effective separation and purification of C2 gases under mild conditions. As an emerging class of porous materials, metal-organic frameworks (MOFs) show great promise in the field of gas separation and purification due to their ultra-high specific surface area, easily modifiable pore surfaces, structural designability and functionalization. Herein, we summarize recent research advances by use of MOFs sorbents for the separation and purification of C2 gases, including C2H2/C2H4, C2H6/C2H4 and C2H2/CO2. Relationship between structures and separation mechanism is also explored. Furthermore, challenges and possible research directions related to the further exploration are also discussed.
Recent Progresses in Lanthanide Metal-Organic Frameworks (Ln-MOFs) as Chemical Sensors for Ions, Antibiotics and Amino Acids
Yan Yang, Shuting Xu, Yanli Gai, Bo Zhang, Lian Chen
2022, 41(11): 2211045-2211070  doi: 10.14102/j.cnki.0254-5861.2022-0138
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Various ions and antibiotics, widely used in industry and clinical medicine, respectively, are massively discharged to atmosphere and water, resulting in severe pollutions on environment and potential threats to human health. Besides, amino acids, the primary substances for the establishment of proteins, cells and tissues, are crucial to human health. Therefore, seeking effective and practicable materials to detect aforesaid analytes is vitally meaningful. Metal-organic frameworks centered with lanthanide ions (Ln-MOFs), also known as lanthanide coordination polymers, are considered as a charming category of multi-functional hybrid crystalline materials with fascinating structures and incomparable luminescent characteristics. Benefited from their unique merits, Ln-MOFs have been largely developed as excellent luminescent sensors for fast and efficient sensing various analytes. In this review, we aim to introduce some of the recent researches between 2018 to 2022 on Ln-MOFs applied as chemical sensors for ions, antibiotics and amino acids based on luminescent quenching and enhancing effects, and provide an update and summary for the latest progresses in this field.
A Review on Crystalline Porous MOFs Materials in Photocatalytic Transformations of Organic Compounds in Recent Three Years
Hao Zhang, Ru Sun, Da-Cheng Li, Jian-Min Dou
2022, 41(11): 2211071-2211083  doi: 10.14102/j.cnki.0254-5861.2022-0140
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Metal-organic frameworks (MOFs) have always been the focus of chemists due to their diverse structures, adjustable pore size and high stability since they came into being. In recent years, as one of the most significant applications of MOFs porous materials, photocatalytic organic compounds transformation has made full-grown progress both in the preparation of the catalysts themselves and in the scope of specific applications. Herein, we summarize the research progress of MOFs catalysts for photocatalytic transformations of organic compounds in recent three years. Some outstanding works on the preparation and synthesis strategies of photocatalysts are introduced firstly, including internal optimization and modification of MOFs, POM@MOF composite and core-shell MOF@COF hybrids. The second part is about the application of diverse types of organic reactions, including dual-function organic reactions, catalytic oxidation reactions, comprehensive utilization of CO2 and degradation of organic pollutants. Besides, the development opportunities and some problems to be solved in this field are proposed.
Recent Progress in Covalent Organic Frameworks (COFs) for Electrocatalysis
Cha Li, Zining Qiu, Hongming Sun, Yijie Yang, Cheng-Peng Li
2022, 41(11): 2211084-2211099  doi: 10.14102/j.cnki.0254-5861.2022-0162
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Electrocatalysis provides various technologies for energy storage and conversion, which is an important part of realizing sustainable clean energy for the future. COFs, as emerging porous crystalline polymers, possess high specific surface areas, tunable pore structures, high crystallinity and tailorable functionalization. These features endow COFs with abundant active sites and fast electron transport channels, making them potentially efficient electrocatalysts. In recent years, COF-based electrocatalysts have been widely developed for hydrogen evolution reaction (HER), hydrogen oxidation reaction (HOR), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), nitrogen reduction reaction (NRR) and carbon dioxide reduction reaction (CO2RR). In this review, design strategies of COF-based electrocatalysts are briefly summarized, including applying COF as supports, introducing active metals in COF, constructing two-dimensional conductive COF, formation of COF-based hybrid and pyrolysis of COF to obtain carbon materials. Then, the recent research progress in COF-derived catalysts for specific electrocatalytic reactions is introduced systematically. Finally, the outlook and challenges of future applications of COFs in electrocatalysis are highlighted.
Recent Advances in Metal-Organic Cages-Based Composite Membranes
Guoliang Liu, Xiao-Qin Liu, Lin-Bing Sun
2022, 41(11): 2211100-2211109  doi: 10.14102/j.cnki.0254-5861.2022-0178
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Conventional polymeric membranes face several limitations, such as the trade-off between permeability and selectivity, and physical aging or membrane fouling. In this case, fabrication of composite membranes, usually including mixed matrix membranes (MMMs) or thin film nanocomposite (TFN) membranes by introduction of porous materials as fillers has gained much attention. To achieve excellent membrane performance, it is of great importance to select proper porous materials to avoid agglomeration or precipitation during the composite membrane fabrication processes. Metal-organic cages (MOCs) have been explored as additives for the fabrication of defectfree composite membranes owing to their diversified topologies, well-defined pore structures, nanoscale size, and excellent solubility. This review mainly focuses on the recent advances in applications of MOCs for membrane separation, including synthetic artificial channels, reverse osmosis, nanofiltration, pervaporation and gas separation. Besides, two types of MOCs that have been extensively investigated for composite membrane fabrication are also highlighted. Furthermore, challenges and possible directions are also discussed in details, hoping to provide insightful guidance on the development of more MOC-based membranes with impressive separation performance.
Article
A Water-Stable 3D Eu(Ⅲ)-Organic Framework as a Bi-Functional Ratiometric Luminescent Sensor for Fast, Sensitive and Selective Detection of ODZ and Hg2+ in Aqueous Media
Xiuting Gao, Nana Chen, Minglei Cao, Yang Shi, Qingfu Zhang
2022, 41(11): 2211110-2211116  doi: 10.14102/j.cnki.0254-5861.2022-0171
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The fast, sensitive and selective detection of some antibiotics and heavy metal cations in water is highly desirable for environmental protection and human health, but it is still currently challenging. In this work, a new luminescent Eu(III)-based metal-organic framework (MOF), {[(CH3)2NH2][Eu(L)2(H2O)2]·xDMF}n (1) [H2L = 4, 4'-((naphthalene-1, 4-dicarbonyl)bis(azanediyl))dibenzoic acid], was solvothermally synthesized. Complex 1 exhibits good water stability and luminescent property and could serve as a bi-functional ratiometric luminescent sensor for fast, sensitive and selective detection of ornidazole (ODZ) and Hg2+ in aqueous solution. The corresponding luminescent mechanism has also been discussed. This work indicates that 1 as a promising luminescent material exhibits luminescent quenching behavior for ODZ and luminescent enhancement behavior for Hg2+ in H2O, which will promote the practical application of Ln-MOF-based ratiometric luminescent sensors in monitoring antibiotics and metal ions pollutants in the environmental water matrices.
Article
Synthesis of Axially Coordinated Cobalt Porphyrin/graphene Oxide Nanocomposite for Enhanced Electrocatalytic CO2 Reduction to CO
Wei-Feng YOU, Xiao XU, Ai-Hui CAO, Zhi-Jie TAO, Long-Tian KANG
2022, 41(3): 2203001-2203011  doi: 10.14102/j.cnki.0254-5861.2011-3247
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The electrocatalysts containing cobalt-pyrrolic nitrogen-carbon (Co-N4-C) moiety for CO2 reduction reaction (CO2RR) have caught much attention. However, the effects of Co valence state and its synergy with graphene substrate are not clear yet. In this work, cobalt porphyrin (CoTPP) molecule with the intrinsic Co-N4-C moiety is successfully combined with graphene oxide (GO) via three kinds of liquid-phase methods. The ratio of CoTPP to GO and the valence state of Co atom are studied to explore their catalysis for CO2RR to CO. It is found that axially-coordinated Co(Ⅲ)TPPCl/GO nanocomposites synthesized via a chemical method exhibit better ability for CO2RR, as compared with Co(Ⅱ)TPP+GO and/or Co(Ⅲ)TPPCl+GO nanocomposites obtained via a physically mixing way. After optimizing the ratio of CoTPP to GO, the Faradaic efficiency (FE) is more than 90% for CO2RR to CO between −0.7 and −0.8 V vs. reversible hydrogen electrode (RHE) in Co(Ⅲ)TPPCl/GO75. The synergy between CoTPP and GO and the effect of Co valence state are systematically investigated, indicating that their strong interaction plays the key role in electrocatalytic CO2RR.
Syntheses, Crystal Structures and Property of Pyridine Zinc(Ⅱ) Complexes Based on Halogenated Salicylaldehyde Schiff Base
Wu-Jiu JIANG, Peng-Hui NI, Fang-Fang MAO, Yu-Xing TAN
2022, 41(3): 2203012-2203018  doi: 10.14102/j.cnki.0254-5861.2011-3285
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Schiff base pyridine zinc(Ⅱ) complexes 1~4 were synthesized by the reaction of the 2-((2-hydroxybenzylidene)amino)phenol Schiff base with appended donor functionality, zinc acetate, and pyridine. The results of the structural characterization of the complex show that they have the same coordination mode and similar steric structure. Complexes 1 and 3 form a one-dimensional chain structure and two-dimensional grid structure by lots of hydrogen bonds, respectively. Thermogravimetric analysis shows complexes 1~4 can exist stably below 150 ℃. The results of the fluorescence quenching experiments between the complexes and DNA-EB show that the interaction between them is intercalation, and the effect of complex 1 is the most obvious. It is speculated that the steric hindrance of complex 1 is relatively small, and the aromatic ring on the ligand is more likely to inserted into the base pair of DNA.
Theoretical Measurements of Quantitative Effects Caused by Spectator Ligands on Palladium-catalyzed C−H Activation
Xiao-Si MA, Yong-Zhu ZHOU, Lei ZHANG
2022, 41(3): 2203019-2203029  doi: 10.14102/j.cnki.0254-5861.2011-3286
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Ligands can definitely influence C−H activation at the metal center. A ligand not directly participating in the reaction is called a spectator ligand. We attempt to quantitatively characterize the effects of diverse spectator ligands on C−H activation at palladium. We designed a model palladium catalyst and selected an array of spectator ligands, such as methoxyl, amide, methyl, phenyl, cyanide, fluorine, chlorine, and several neutral ligands, and performed density functional theory calculations on the mechanism and energetics of C−H activation reactions of benzene with different catalysts. Univalent ligands have substantially larger effects than neutral ligands, and strongly σ-donating ligands (e.g., methyl and phenyl) severely hinder the C−H activation in progress. A ligand trans to the reaction site influences C−H activation more than that cis to the reaction site, indicating electronic effects to be at work. For example, the existence of a methyl ligand raises the barrier height of C−H activation by 6.4 or 14.4 kcal/mol when it is placed at the position cis or trans to the C−H activation site. The effects of poorly σ-donating ligands are not significant and similar to those of the κ1-acetate ligand. Some σ-donating and π-accepting ligands, such as cyanide and isonitrile, hinder the C−H activation trans to them but appear to facilitate the C−H activation cis to them. On the basis of molecular orbital analyses, a chemical model is proposed to understand the observed ligand effects. Lastly, the conclusions are applied to explain the plausible mechanism of the dehydrogenative Heck coupling.
Functionalized Metal-organic Frameworks for White Light Emission and Highly Sensitive Sensing of PA and Fe3+/Al3+
Jing-Jing HUANG, Dan ZHAO, Guo-Jie YIN
2022, 41(3): 2203030-2203039  doi: 10.14102/j.cnki.0254-5861.2011-3304
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Three isomorphic Ln-MOFs [Ln(bcbob)(H2O)(DMF)] (Ln = Tb for 1, Eu for 2, Gd for 3; DMF = N, N-dimethylformamide) have been constructed from a semi-rigid V-shaped organic linker 3, 5-bis((4′-carboxyl-benzyl)oxy)benzoilate acid (H3bcbob) under solvothermal conditions. X-ray single-crystal diffraction analysis reveals that they exhibit a two-dimensional (2D) layered structure. Compounds 1~3 show the characteristic green and red emissions of Ln3+ and blue emission arising from the organic ligand, respectively. Based on their photoluminescence properties, the white-light emitting materials 4 and 5 with longer fluorescence lifetime (ms grade) and higher quantum yield (e.g. 40.61% for 4) are fabricated. Remarkably, 1 exhibits good sensing ability on nitroaromatic compounds, especially for picric acid (PA). In addition, 1 is still a highly selective sensing material for Fe3+ and Al3+.
A Double Crown Hexakis[(Di-μ-benzylthio) Nickel] Cluster: Synthesis, Structure and Properties
E LIU, Ai-Quan JIA, Qian-Feng ZHANG, Fang-Fang JIAN
2022, 41(3): 2203040-2203046  doi: 10.14102/j.cnki.0254-5861.2011-3309
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The double crown hexakis[(di-μ-benzylthio) nickel] cluster, [Ni6(SCH2C6H5)12]·C2H5OH, was obtained by reacting C6H5CH2SNa with [(CH3)2CHOCS2]2Ni in EtOH. The results of electrochemical studies show that [Ni6(SCH2C6H5)12] is a quasi-reversible process. The crystal structure of [Ni6(SCH2C6H5)12]·C2H5OH is composed of discrete [Ni6(SCH2C6H5)12] and C2H5OH solvent molecules. Each Ni atom is surrounded by four S atoms of the μ2-SCH2C6H5 ligands in a distorted square-planar structure. The C6H5CH2S- side chains are arranged in the axial and equatorial positions, alternately, concerning the pseudo-hexagonal axis of the molecule. Strong π-π and C–H···π effects form the supramolecular nano-channel along the a-axis in the crystal, which wraps the solvent ethanol molecules in it. In addition, a wall is formed along the b- and c-axes, so that the ethanol molecules can freely enter and leave along the a-axis. These effects result in the ability of the title compound to adsorb and desorb ethanol molecules. Thermogravimetric analysis and powder X-ray diffraction at different temperature are provided to demonstrate this point.
Two Polynuclear Fe Complexes with Boat-like Core: Syntheses, Structures and Magnetic Properties
Na YANG, Hua YANG, Hai-Quan TIAN, Da-Cheng LI, Jian-Min DOU
2022, 41(3): 2203047-2203054  doi: 10.14102/j.cnki.0254-5861.2011-3311
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Two novel polynuclear complexes {NaFe4(μ4-O)(L)4(μ2-Cl)[Fe(CN)5NO](H2O)(DMF)2} (1) and {NaFe4(μ4-O)(L)4(μ2-OEt)[Fe(CN)5NO](H2O)(DMF)2} (2) have been prepared using the tetradentate N-(2-hydroxyethyl)-3-methoxysalicylaldimine Schiff-base ligand (H2L) with the help of [Fe(CN)5NO]2- linkers, where the ligand was in situ synthesized through the condensation of o-vanillin and ethanolamine in the formation process of complexes. The resulting complexes possess "boat-like" structure constructed through three Fe ions and one Na ion with the fourth Fe ion acting as the "paddle". The "hull bottom" contains an eight-membered metallamacrocycle with metallacrown-like motif and [-M-O-] repeat unit. Both complexes display three-dimensional frameworks through C–H∙∙∙N hydrogen bonds, C–H∙∙∙Cl hydrogen bonds, and π-π stacking interactions with the introduction of solvent molecules and coordination anions. Variable-temperature magnetic susceptibility measurements reveal strong antiferromagnetic couplings between the metal centers in complexes 1 and 2.
Synthesis, Crystal Structure and Fe3+ Recognition of a Fluorescent Probe Based on Quinazolinone Derivative
Lin WANG, Xiao-Feng WANG, Meng-Wei XUE, Shu-Rong DUAN, Ting LI, Zhen-Zhen YU, Dun-Lin ZHANG
2022, 41(3): 2203055-2203061  doi: 10.14102/j.cnki.0254-5861.2011-3325
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A novel quinazolinone derivative ethyl 2-(2-methyl-4-oxo-1, 2, 3, 4-tetrahydroquinazolin-2-yl) acetate (EMOTA) was synthesized and characterized by HRMS, 1H NMR, 13C NMR spectroscopy and X-ray crystallography, and the ion recognition performance of the compound was studied by fluorescence analysis measurements. The results showed that probe EMOTA has a rapid fluorescence response, good selectivity and sensitivity to Fe3+. When the concentration of Fe3+ was in the range of 0~10.0 × 10-5 mol/L, the fluorescence quenching could be affected by the probe, and the detection limit was 1.65 × 10-6 mol/L. In addition, the identification and detection of Fe3+ in water samples were studied, and the results showed that probe EMOTA has high efficiency, significant sensitivity and high selectivity on the recognition and detection of Fe3+ in water samples, which indicates probe EMOTA has a practical application prospect.
MOF-Conductive Polymer Composite Film as Electrocatalyst for Oxygen Reduction in Acidic Media
Rui-Xue ZHUGE, Peng-Chao SHI, Teng ZHANG
2022, 41(3): 2203062-2203069  doi: 10.14102/j.cnki.0254-5861.2011-3350
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A metal-organic framework (MOF)-conductive polymer composite film was constructed from PCN-222(Fe) nanoparticles and PEDOT: PSS solution by simple drop-casting approach. The composite film was tested as an electrocatalytic device for oxygen reduction reaction (ORR). The combination of PCN-222(Fe) MOF particles and conductive PEDOT matrix facilitates electron transfer in the composite material and improves the ORR performance of PCN-222(Fe). Levich plot and H2O2 quantification experiment show that PCN-222(Fe)/PEDOT: PSS film mainly catalyzes two-electron oxygen reduction and produces H2O2.
High-humidity Sensor of a New Trinuclear Ti3-Oxo Cluster
Shi-Hao SUN, Qian-Chong ZHANG, Xiao-Liang YE, Chivanje evulu KASHI, Wen-Hua LI, Guan-E WANG, Gang XU
2022, 41(3): 2203070-2203076  doi: 10.14102/j.cnki.0254-5861.2011-3351
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Crystalline polyoxo-titanium clusters (PTCs), as a molecular model of TiO2 nanomaterials, have attracted unprecedented attention due to their designable structure, tunable band gap, catalysis, and photochromic properties. A new trinuclear Ti3-oxo cluster, [Ti3(μ2-O)(μ3-O)(abz)6(OiPr)2]·CH3CN·H2O (Ti3), was synthesized by solvothermal method with a yield of 60% by using 4-aminobenzoic acid as ligand. Single-crystal X-ray diffraction shows that it has a [Ti3(μ2-O)(μ3-O)(abz)6(OiPr)2] trinuclear cluster structure. Ti3 crystallizes in monoclinic space group P21/c with a = 11.091(1), b = 22.837(2), c = 22.754(1) Å, β = 90.580(6)°, V = 5763.0(6) Å3, Z = 4, Dc = 1.345 g·cm-3, F(000) = 2412, μ = 2.743 mm−1, R = 0.0796, and wR = 0.2260 (I > 2σ(I)). Ti3 shows typical semiconductive behavior determined by temperature-dependent conductivity test. The chemiresistive humidity sensor fabricated by Ti3 showed good performance, including high response (four orders of magnitude current change from 0 to 100% RH) and fast response time (160 s) and recovery time (26 s).
Controllable Synthesis, Polar Behavior and Photoelectric Properties of BiOCl Microplates
Li-Xin LI, Chen CHEN, Zi-Hao LI, Fei-Fei WANG, Yun LIU, Zhi-Guo YI
2022, 41(3): 2203077-2203084  doi: 10.14102/j.cnki.0254-5861.2011-3352
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Bismuth oxychloride (BiOCl) square microplates were prepared via a facile hydrothermal method. The X-ray diffraction patterns of the samples reveal a tetragonal BiOCl phase, and the scanning electron microscopy images show plate-like structures with large lateral size of 3~6 μm and thickness in the range of 100~300 nm. The effects of surfactant, reaction temperature and duration on the morphology of BiOCl powders are systematically investigated. The polar behavior of a BiOCl single-crystalline microplate is examined by using piezoresponse force microscopy evidenced over 80 pm displacement under 40 V bias voltage. In addition, the photoelectric performance of the BiOCl microplates is evaluated by using electrochemical workstation with three-electrode system, and large photocurrent densities (over 0.5 μA/cm2) and fast photoresponse (0.7~1.1 s) are detected by applying both 365 nm monochromatic light and sunlight illumination. The surface potential changes of BiOCl microplate under different light condition, characterized by in-situ Kelvin probe force microscopy, further verify the separation ability of the photo-induced charge carriers. These findings would be beneficial for further design photocatalytic and piezocatalytic materials.
Communication
Improvement of the Selectivity for Hydrogen Peroxide Production via the Synergy of TiO2 and Graphene
Yun-Long SUN, Jun-Heng HUANG
2022, 41(3): 2203085-2203091  doi: 10.14102/j.cnki.0254-5861.2011-3299
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To replace the four-electron transferred pathway of oxygen reduction reaction (ORR) by two-electron transferred pathway of ORR (2e- ORR) is desirable for the production of hydrogen peroxide with added-value. The development of electrocatalysts with high selectivity toward 2e- ORR is of great interest but it is still a challenge. Here, we synthesized the graphene-supported titanium dioxide nanocomposite as the 2e- ORR catalysts by a combinative process of hydrothermal methods and calcination. Due to the synergistic effect between the graphene with high conductivity and the titanium dioxide with defect sites, the composite TiO2/graphene exhibits the improved selectivity (up to 90%) for oxygen converting into hydrogen peroxide.
Synthesis, Crystal Structure and Fluorescent Properties of a 1D Europium Coordination Polymer with 2,5-Furandicarboxylic Acid
Han ZHANG, Xiang LI, Yaseen MUHAMMAD, Hui-Feng XIE, Yi-Han ZANG, Ming-Lu FANG, Shao-Jie LIU, Hao WANG
2022, 41(3): 2203092-2203099  doi: 10.14102/j.cnki.0254-5861.2011-3303
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By using solvothermal method, a one-dimensional chain compound [KEu2(FDCA)3(H2O)9·0.5(FDCA)] (1) was synthesized. Single-crystal X-ray diffraction data reveal that 1 crystallizes in monoclinic system, space group P21/n with a = 12.1996(1), b = 18.6454(2), c = 17.7123(2) Å, β = 98.8460(10)°, Dc = 1.753 g/cm3, Z = 2, V = 3981.03(7) Å3, R = 0.0544 and wR = 0.1511 for 7886 observed reflections with I > 2σ(I). In 1, three FDCA2– ligands construct a "23-crown-9-like" structure as the second building units (SBUs) to further form an infinite 1D chain. Meanwhile, the fluorescent result reveals that compound 1 can selectively and sensitively sense Fe3+ by the fluorescence quenching.
Anion-templated Self-assembly for the Preparation of Silver-t-butylthiolate Clusters
Jun-Ling JIN, Yang-Lin SHEN, Li-Wei MI, Yun-Peng XIE, Xing LU
2022, 41(3): 2203100-2203107  doi: 10.14102/j.cnki.0254-5861.2011-3357
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Silver thiolate polymers are intercepted to form different structural fragments when reacting with variant solubilizing reagents, which usually serve as the starting point for the preparation of clusters. However, such a process is still far from clear. Herein, we report the controlled synthesis of silver-t-butylthiolate clusters from reactions of polymeric [AgtBuS]n and suitable templates in the presence of solubilizing reagents to offer a detailed look at the mechanism of cluster's formation. As the provided solubilizing reagents have weak coordination ability, such as O- or N-donating ligands, the obtained polymeric compound retains the linear structure pattern that S and Ag atoms are arranged alternately. When extra templates NO3 and CO32– are applied, the disk-like clusters Ag19 and Ag20 are constructed with the same [AgtBuS]5 circles that may directly cyclize from the linear [AgtBuS]n fragments. In contrast, (EtO)2PS2 and (iPrO)2PS2 anions have large size and strong coordination ability rendering the structure of the polymer completely fragmented. Thus extremely short [AgtBuS]n pieces with silver ions and solubilizing ligands assemble around the templates V2O74– and W2O94–, leading to the formation of clusters Ag22 and Ag24.
Letter
Discovery of 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine as Novel Cyclin-dependent Kinases 4 and 6 Dual Inhibitors via 3D-QSAR and Molecular Simulation
Le FU, Li-Nan ZHAO, Hong-Mei GUO, Na YU, Wen-Xuan QUAN, Yi CHEN, Mao SHU, Rui WANG, Zhi-Hua LIN
2022, 41(3): 2203108-2203124  doi: 10.14102/j.cnki.0254-5861.2011-3270
[摘要]  (1) [HTML全文] (1) [PDF 5795KB] (1)
摘要:
Cyclin D dependent kinases 4/6 regulate the entry of cells into S phase and are effective target for the discovery of anticancer drugs. In this article, 3D-QSAR modeling including comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis fields (CoMSIA) was implemented on 52 dual CDK4/6 inhibitors. As a result, we obtained a pretty good 3D-QSAR model, which is CoMFACDK4 with q2 to be 0.543 and r2 to be 0.967; CoMSIACDK4 with q2 being 0.518 and r2 being 0.937; CoMFACDK6 with q2 to be 0.624 and r2 to be 0.984; CoMSIACDK6 with q2 being 0.584 and r2 being 0.975. Molecular docking confirmed the important residues for interactions. Molecular dynamics simulation further confirmed binding affinity with key residues of protein, such as Lys22, Lys35, Val96 for CDK4 and Lys43, His100, Val101 for CDK6 at the active sites. Then these results offered new directions to explore new inhibitors of CDK4/6. Finally, we designed 10 novel compounds with promising expected activity and ADME/T properties, and provided referable synthetic routes.
Antibiotic Silver Particles Coated Graphene Oxide/polyurethane Nanocomposites Foams and Its Mechanical Properties
Zhi YANG, Kun-Rong LI, Yuan-Ye ZHANG, Jia-Le HU, Tian-Yuan LI, Zi-Xiang WENG, Li-Xin WU
2022, 41(3): 2203125-2203131  doi: 10.14102/j.cnki.0254-5861.2011-3273
[摘要]  (1) [HTML全文] (1) [PDF 2726KB] (1)
摘要:
Silver nanoparticles (AgNPs) are widely adopted in polyurethane foams (PUFs) as a type of antibacterial agent. However, due to its poor interfacial interaction, AgNPs are difficult to be dispersed in the polymer matrix uniformly, which deteriorates the enhancement effect. In this paper, silver-coated graphene nanocomposite (Ag/GO) is prepared by an enzyme reductant which is efficient and non-toxic. Compared with traditional antibacterial agent, the Ag/GO nanoparticles can be uniformly dispersed in the nanocomposite, which means that Ag/GO can be well-dispersed into the polyurethane foams (PUFs). Compared with AgNPs modified PUFs, the as-prepared Ag/GO modified PUFs have a 1.85% improvement in resilience, 7.9% improvement in tensile strength, 6.52% improvement in tensile elongation, and 8.74% improvement in bacteriostats rate at a loading of 0.4%.
A Novel Salicylaldehyde Schiff-base Fluorescent Probe for Selective Detection of Cu2+Ion
Yuan-Da LI, Jin-Hao KUANG, Hai-Bo QIN, Ke-Xiang LIU, Xu FAN, Zhong-Yan LI, Lin YUAN
2022, 41(3): 2203132-2203136  doi: 10.14102/j.cnki.0254-5861.2011-3288
[摘要]  (1) [HTML全文] (1) [PDF 305KB] (1)
摘要:
A novel Schiff-base fluorescent probe 6, 6'-((1E, 1'E)-(ethane-1, 2-diylbis(azaneylylidene))bis-(methaneylylidene))bis(3-(diethylamino)phenol) (L) was derived from the 2:1 M condensation of 4-(diethylamino)-2-hydroxybenzaldehyde with ethylenediamine and characterized by 1H NMR, 13C NMR and FT-IR spectroscopies. The results of spectral analysis showed that the probe L is selective and sensitive to Cu2+. The detection limit of L is found to be 19 nmol·L-1. There is a good linear relationship between the fluorescence intensity of probe L and the concentration of Cu2+ in the range of 0 to 20 μmol·L-1. X-ray crystal structure of the L-Cu2+ complex and the Job plot revealed a 1:1 L-Cu2+ identification.
Construction of the Molecular Structure Model of the Zhaotong Lignite Using Simulation and Experiment Data
Dian-Kai ZHANG, Yan-Hong LI, Li-Ping CHANG, Chang-Yu ZI, Yuan-Qin ZHANG, Guo-Cai TIAN, Wen-Bo ZHAO
2022, 41(3): 2203137-2203147  doi: 10.14102/j.cnki.0254-5861.2011-3293
[摘要]  (1) [HTML全文] (1) [PDF 400KB] (1)
摘要:
Aiming to better understand the physiochemical properties of lignite, we select Zhaotong lignite as object and adopt simulation and experiment data to construct its molecular structure. Firstly, the important parameters including carbon skeleton, valence state and functional group of the sample are obtained by ultimate analysis, 13C NMR, XPS and Py-GC/MS. Results indicate that the ratio of aromatic carbon and aromatic bridge carbon to surrounding carbon of the sample are 40.32% and 0.14, respectively. Such results imply that the aromatic structure of the sample is dominated by benzene and naphthalene. Moreover, the ratio of aliphatic carbon is 51.55%, and the aliphatic structure is mainly comprised by methyl, methylene, quaternary carbon and oxygen-aliphatic carbon. Oxygen atoms principally exist in ether, carbonyl and carboxyl groups, of which ether accounts for 70.2%. Additionally, the contents of pyridine, pyrrole and quaternary nitrogen are 25.2%, 46.3% and 13.0%, respectively. Based on the aforementioned results, the molecular structure model of Zhaotong lignite is constructed by the method of computer-aided molecular design. Subsequently, the molecular formula of Zhaotong lignite is calculated as C183H211O55N4. Finally, in order to verify the reasonability of the constructed model, the 13C NMR of the molecular structure model is simulated by employing the basis set of GIAO/6-31G at the Gaussian 09 computing platform. These simulated results agree well with the experimental ones, which suggests that the molecular structure model of Zhaotong lignite is accurate and reasonable.
Manganese(Ⅱ) and Copper(Ⅰ) Compounds Based on Two Derivatives of Imidazo[1, 5-a]pyridine: Synthesis, Structures, Magnetic Properties, and Catalytic Activity
Qian ZHANG, Yan-Feng CUI, Xia-Mei ZHANG, Ya-Hong LI, Jin-Lei YAO
2022, 41(3): 2203148-2203154  doi: 10.14102/j.cnki.0254-5861.2011-3296
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The utilization of 2, 6-bis(imidazo[1, 5-a]pyridin-3-yl)pyridine (bipp) and 3-(pyridin-2-yl)imidazo[1, 5-a]pyridine (pip) in the compounds of manganese(Ⅱ) and copper(Ⅰ) ions is presented. Two complexes, [Mn(bipp)(SO4)(H2O)]n (1) and [Cu(pip)2]ClO4 (2), were prepared with different characteristics in structure. Compound 1 exhibits a one-dimensional chain topology, and 2 is a homoleptic Cu(Ⅰ) complex. The dc magnetic susceptibility investigations reveal the antiferromagnetic (AF) Mn…Mn interactions in complex 1. The catalytic activity of compound 2 toward ketalization reactions was studied. Complex 2 exhibits high activity for the ketalization transformations of aliphatic ketones.
Structural and Electronic Properties of Lutetium Doped Germanium Clusters LuGen(+/0/-) (n = 6~19): A Density Functional Theory Investigation
Zhao-Feng YANG, Zhen-Zhu CAO, U Rehman Aziz, Ju-Cai YANG
2022, 41(3): 2203155-2203165  doi: 10.14102/j.cnki.0254-5861.2011-3305
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摘要:
Structural growth mechanism, energetics, and electronic properties of cationic, neutral, and anionic lutetium doped germanium cluster LuGen(+/0/-) (n = 6~19) were comprehensively studied by the ABCluster unbiased global search technique with a hybrid density functional theory approach. Compared to the experimental PES, the anion evolution of structure can be clearly defined as four-phase: from the adsorbed to the link structure, then to the half cage motif, and finally to the endohedral structure. The results revealed that the LuGe16- as Frank-Kasper structure with high symmetry of Td can greatly enhance the stabilities. Doped structures have shown thermodynamic stability and appropriate energy gap. These materials are suitable semiconductors. Various approaches, including quasi-spherical geometry with closed-shell model, aromaticity, UV-Vis spectra, density of states (DOS) and partial density of states (PDOS) were applied to further support the results.
QSAR Models for Predicting Additive and Synergistic Toxicities of Binary Pesticide Mixtures on Scenedesmus Obliquus
Ling-Yun MO, Bai-Kang YUAN, Jie ZHU, Li-Tang QIN, Jun-Feng DAI
2022, 41(3): 2203166-2203177  doi: 10.14102/j.cnki.0254-5861.2011-3306
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Pesticides released into the environment may pose potential risks to the ecological system and human health. However, existing toxicity data on pesticide mixtures still lack, especially regarding the toxic interactions of their mixtures. This study aimed to determine the toxic interactions of binary mixtures of pesticides on Scenedesmus Obliquus (S. obliquus) and to build quantitative structure-activity relationship models (QASR) for predicting the mixture toxicities. By applying direct equipartition ray method to design binary mixtures of five pesticides (linuron, dimethoate, dichlorvos, trichlorfon and metribuzin), the toxicity of a single pesticide and its mixture was tested by microplate toxicity analysis on S. obliquus. The QASR models were built for combined toxicity of binary mixtures of pesticides at the half-maximal effective concentration (EC50), 30% maximal effective concentration (EC30) and 10% maximal effective concentration (EC10). The results showed that the single toxicity follows: metribuzin > linuron > dichlorvos > trichlorfon > dimethoate. The mixtures of linuron and trichlorfon, dichlorvos and metribuzin, dimethoate and metribuzin induced synergetic effects, while the remaining binary mixtures exhibited additive. The developed QSAR models were internally validated using the leave-one-out cross-validation (LOO), leave-many-out cross-validation (LMO), bootstrapping, and y-randomization test, and externally validated by the test sets. All three QSAR models satisfied well with the experimental values for all mixture toxicities, and presented high internally (R2 and Q2 > 0.85) and externally (QF12, QF22, and QF32 > 0.80) predictive powers. The developed QSAR models could accurately predict the toxicity values of EC50, EC30 and EC10 and were superior to the concentration addition model's results (CA). Compared to the additive effect, the QSAR model could more accurately predict the binary mixture toxicities of pesticides with synergistic effects.
Mechanism Study of Aliskiren and Its Analogues by Molecular Dynamic Simulation
Wen-Li YAN, Zhen LIANG, Xing-Lian YU, Rong ZHANG
2022, 41(3): 2203178-2203185  doi: 10.14102/j.cnki.0254-5861.2011-3308
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The further interaction mechanism towards renin inhibitors was revealed by comparison of renin with different active inhibitors in aqueous solution. Molecular docking and molecular dynamics (MD) simulations were combined for the research. The results reflected that electrostatic and hydrophobic effects were the major interactions for renin inhibitors forming complexes with renin, and some residues were the key to the formation of complex, especially Asp38/Asp226. The factor of different activities performed in renin inhibitors was illustrated as well. For the higher active renin inhibitor, it possessed stronger affinity with renin, and its detected conformation was more extended to fit for the key binding site. This promoted the capacity to form special interactions with the key residues. While conformation of the lower active renin inhibitor performed folded in the active site of renin, the interactions to the important pocket S3sp was restricted, resulting in undesirable bioactivity.
Synthesis and Crystal Structure of a Copper(II) Complex with Funnel-like Ligand Based on Calix[6]arene
Yi-Feng WANG, Mou-Hai SHU
2022, 41(3): 2203186-2203192  doi: 10.14102/j.cnki.0254-5861.2011-3312
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The preparation method of a funnel like ligand derived from calix[6]arene and tris(2-pyridyl-methyl)anime has been improved. The Cu(II) complex was obtained and characterized by ESI-MS, EPR, UV-Vis spectra and crystallographic analysis. In the complex, a guest acetonitrile molecule is introduced into the cavity of the ligand host via the coordination with Cu(II) center.
Discovery of Benzimidazole Derivatives as Novel Aldosterone Synthase Inhibitors: QSAR, Docking Studies, and Molecular Dynamics Simulation
Hong-Mei GUO, Na YU, Le FU, Guang-Ping LI, Mao SHU, Zhi-Hua LIN
2022, 41(3): 2203193-2203210  doi: 10.14102/j.cnki.0254-5861.2011-3321
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Aldosterone synthase inhibitors can lessen the production of aldosterone in organisms, which effectively affecting the treatment of hypertension. A series of computational approaches like QSAR, docking, DFT and molecular dynamics simulation are applied on 40 benzimidazole derivatives of aldosterone synthase (CYP11B2) inhibitors. Statistical parameters: Q2 = 0.877, R2 = 0.983 (CoMFA) and Q2 = 0.848, R2 = 0.994 (CoMSIA) indicate on good predictive power of both models and DFT's result illustrates the stability of both models. Besides, Y-randomization test is also performed to ensure the robustness of the obtained 3D-QSAR models. Docking studies show inhibitors rely on π-π interaction with residues, such as Phe130, Ala313 and Phe481. Molecular dynamics simulation results further confirm that the hydrophobic interaction with proteins enhances the inhibitor's inhibitory effect. Based on QSAR studies and molecular docking, we designed novel compounds with enhanced activity against aldosterone synthase. Furthermore, the newly designed compounds are analyzed for their ADMET properties and drug likeness and the results show that they all have excellent bioavailability.
Preparation, Crystal Structure and Fungicidal Activity of N-(5-(benzofuranol-7-oxymethyl)-1, 3, 4-thiadiazol-2-yl)amide Compounds
Chun-Nong WANG, Tai-Ning ZENG, Sheng-Nan LI, Wan LI, Long-Fei LI, Fei CAO, Zi-Hui YANG
2022, 41(3): 2203211-2203217  doi: 10.14102/j.cnki.0254-5861.2011-3326
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A variety of new N-(5-(benzofuranol-7-oxymethyl)-1, 3, 4-thiadiazol-2-yl)amide compounds (8a-i) were synthesized through four steps from benzofuranol as raw materials. The crystal structure of compound 8a (C17H21N3O3S, Mr = 347.43) was measured by X-ray diffraction, which was classified as monoclinic system, Z = 4, V = 1742.72(8) Å3, Dc = 1.324 Mg/m3, F(000) = 736, S = 1.03, μ = 0.21 mm-1, space group P21 with a = 9.9177(3), b = 8.9519(2), c = 19.8679(5) Å, the final R = 0.035 and wR = 0.105 for 3873 observed reflections (I > 2σ(I)). The X-ray structure presented N(3)–H(3)···N(2) and C(6)–H(6)···O(3) intermolecular hydrogen bonds, which acted as an important role in stabilizing the crystal structure. Additionally, preliminary biological assay on compound 8a showed good fungicidal activity in vivo, with the inhibition of 75% against Pseudoperonospora cubensis at 200 mg/L.
Planar Tetracoordinate Carbon in 6σ + 2π Double Aromatic CBe42– Derivatives
Bo JIN, Jian-Hong BIAN, Xue-Feng ZHAO, Cai-Xia YUAN, Jin-Chang GUO, Yan-Bo WU
2022, 41(3): 2203218-2203226  doi: 10.14102/j.cnki.0254-5861.2011-3332
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As a typical electron deficient element, beryllium is potentially suitable for designing the species with novel non-classical planar hypercoordinate carbon due to high preference for the planar structures by small beryllium-containing clusters. In particular, the CBe54– cluster with a planar pentacoordinate carbon (ppC) had been proved by many previous studies to be an excellent template structure for the systematic design of ppC species through attaching various monovalent atoms on the bridging position of Be–Be edges. In this work, based on the analysis and extension on our recently reported CBe4Mnn–2 (M = Li, Au, n = 1~3) species, we propose that ptC cluster CBe42– is similar to CBe54– in that it can also be employed as a template structure to systematically design the ptC species through binding various monovalent atoms on the bridging position of Be–Be edges. Our extensive screening suggests that the feasible bridging atoms (E) can be found in group 1 (H, Li, Na), group 11 (Cu, Ag, Au), and group 17 (F, Cl, Br, I) elements, leading to total thirty eligible ptC species with CBe4 core moiety (CBe4Enn–2). The ptC atoms in these species are involved into three delocalized σ bonds and a delocalized π bond, thereby not only obeying the octet rule, but also possessing novel 6σ +2π double aromaticity, which significantly stabilizes the ptC arrangement. In addition, the attached bridging atoms can stabilize the CBe4 core ptC moiety by replacing the highly diffused Be–Be two-center two-electron bonds with the much less diffused Be–E two-center two-electron bonds or Be–E–Be three-center two-electron bonds, as reflected by the increasing HOMO-LUMO gaps when the number of bridging atoms increases. Remarkably, the stochastic search algorithm in combination with high level CCSD(T) calculations revealed that twenty-six of the thirty-one ptC species (including previously reported six species) were global energy minima on their corresponding potential energy surfaces, in which twenty-five of them were also confirmed to be dynamically viable. They are suitable for the generation and characterization in gas phase experiments and followed spectroscopic studies.
Homology Modeling, Molecular Docking, and Molecular Dynamic Simulation of the Binding Mode of PA-1 and Botrytis cinerea PDHc-E1
Di RAO, Jun-Bo HE, Jiang-Tao FENG, Wei-Nong ZHANG, Meng CAI, Hong-Wu HE
2022, 41(3): 2203227-2203234  doi: 10.14102/j.cnki.0254-5861.2011-3335
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To reveal the potential fungicidal mechanism of 5-((4-((4-chlorophenoxy)methyl)-5-iodo-1H-1, 2, 3-triazole-1-yl)methyl)-2-methylpyrimidin-4-amine (PA-1) against Botrytis cinerea (B. cinerea), the three-dimensional structure of B. cinerea pyruvate dehydrogenase complex E1 component (PDHc-E1) is homology modeled, as the PA-1 shows potent E. coli PDHc-E1 and B. cinerea inhibition. Subsequent molecular docking indicates the PA-1 can tightly bind to B. cinerea PDHc-E1. Molecular dynamic simulation and MM-PBSA calculation both demonstrate that two intermolecular interactions, π-π stacking and hydrophobic forces, provide the most contributions to the binding of PA-1 and B. cinerea PDHc-E1. Furthermore, the halogen bonding interaction between the iodine atom in PA-1 and OH in Ser181 is also crucial. The present study provides a valuable attempt to homology model the structure of B. cinerea PDHc-E1 and some key factors for the rational structure optimization of PA-1.
Synthesis, Structure and Properties of an Iron Complex with Formally Zero Oxidation State
Lin-Jun ZHU, Tao HUANG, Teng ZHANG
2022, 41(3): 2203235-2203240  doi: 10.14102/j.cnki.0254-5861.2011-3339
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An unusual iron complex with formally zero oxidation state, iron bis(6, 6΄-dimethyl-2, 2΄-bipyridine), was synthesized and its crystal structure was determined. Combination of experimental and theoretical studies reveals that the electronic structure of the complex is best described as Fe(Ⅱ)(Mebipy-)2 with anionic Mebipy- ligands and high-spin Fe(Ⅱ) center.
CoMFA Study on Anti-proliferative Activity of Fluoroquinolone Amide Derivatives
Hui FENG, Jing-Pei CAO, Chang-Jun FENG
2022, 41(3): 2203241-2203247  doi: 10.14102/j.cnki.0254-5861.2011-3343
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The in vitro anti-proliferative activity (pICi, i = hp, ca, hl) of fluoroquinolone (rhodanine α, β-unsaturated ketone) amide compounds, referred to as "fluoroquinolone amide derivatives (FQADs)" towards Hep-3B, Capan-1 and HL60 cells, was studied by the 3D-QSAR method of comparative molecular field analysis (CoMFA). Based on the training set of 14 compounds, the prediction model was established, which was further verified by the test set of 5 compounds with template molecule included. It is found that steric and electrostatic fields contribute 66.8% and 33.2% to pIChp, 61.4% and 38.6% to pICca, and 61.5% and 38.5% to pIChl, respectively. The Rcv2 (i.e, cross-validation coefficient) is 0.324, 0.381, and 0.421 for pIChp, pICca, and pIChl, respectively, while the corresponding R2 (i.e, non-cross-validation coefficient) all reach 0.999. Then, the models were employed to estimate the activities of the training and test compounds, and the results show that the stability and predictability of developed models are very satisfactory. According to the contour maps of steric and electronic fields, bulky groups linked to 2-, 3-, 4-positions of phenyl ring, and electropositive groups near the 4-position and electronegative groups far away may increase the anti-proliferative activity. Using the information provided by the 3D contour maps, four new FQADs owing higher antiproliferative activity were designed, but their effectiveness should be further tested by experiments.
Synthesis and Properties of Dinuclear Europium(Ⅲ) Complex Containing 2-Benzoylbenzoic Acid
Ying-Qun YANG, Chang-Hong LI, Wei LI, Tian-Yi YANG
2022, 41(3): 2203248-2203252  doi: 10.14102/j.cnki.0254-5861.2011-3348
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A new europium(Ⅲ) complex [Eu2(C14H9O3)6(2, 2΄-bipy)2]·(2, 2΄-bipy)2 has been synthesized with 2-benzoylbenzoic acid and 2, 2΄-bipyridine as ligands. Crystal data: triclinic, space group P\begin{document}$ \overline 1 $\end{document}, with a = 13.5251(5), b = 13.9453(5), c = 15.3582(5) Å, α = 76.922(3)º, β = 79.740(3)º, γ = 64.248(4)º, V = 2530.83(18) Å3, Dc = 1.496 g/cm3, Z = 1, μ(Mo) = 1.305 mm-1, F(000) = 1156, the final R= 0.0340 and wR = 0.0638. The Eu(Ⅲ) ion is coordinated by eight atoms to give a distorted square antiprism coordination geometry. The complex exhibits antiferromagnetism in the temperature range of 300~2 K, and two intense fluorescence emission bands arising from the transitions of Eu3+: 5D07F1 (595 nm) and 5D07F2 (618 nm), respectively. In addition, the fluorescence sensing properties of the complex in CrO42- solution were studied.
Synthesis, Crystal Structure and Anti-fungal/Anti-oomycete Activity of New Pyrazole-benzene Carboxamide Derivatives
Zi-Hui YANG, Qing-Song LIU, Yue SUN, Xue-Bao SUN, Wen GU
2022, 41(3): 2203253-2203259  doi: 10.14102/j.cnki.0254-5861.2011-3360
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Four novel pyrazole-benzene carboxamide derivatives 2a~2d were synthesized and characterized by NMR, HRMS spectral method and X-ray diffraction analysis, and were further conducted for screening the anti-fungal/anti-oomycete activity. Compound 2d crystallizes as monoclinic space group P21/c with a = 42.260(4), b = 5.3751(4), c = 8.0129(9) Å, β = 92.958(10)°, V = 1817.7(3) Å3, Z = 4, Mr = 385.41, Dc = 1.408 Mg/m3, S = 1.087, μ = 0.773 mm-1, F(000) = 808, the final R = 0.0763 and wR = 0.2136 for 2657 observed reflections (I > 2σ(I)). The preliminary antifungal assay indicates that the title compounds show fair to excellent antifungal/anti-oomycete activity toward four plant fungi and two crop oomycetes. Among them, compound 2b exhibits the strongest in vitro anti-B. cinerea effects (EC50 = 1.61 mg/L). In vivo test presents compound 2b displays considerable protective and curative effects to tomato fruits infected by B. cinerea. These results indicate that compound 2b would be potential fungicides leads for further development.
Syntheses, Crystal Structures and DNA-Binding Properties of Zn(II) and Mn(II) Complexes Based on Imidazole Derivatives and Carboxylic Acid
Hui-Chao GUAN, Xiao-Tong SONG, Gui-Bao LIU, Shu-Mei YUE
2022, 41(3): 2203260-2203269  doi: 10.14102/j.cnki.0254-5861.2011-3363
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Complexes [Zn(pbm)(5-hip)3] (1), [Zn(pbm)(5-nip)3] (2), [Mn(pbm)(H3btc)2(H2O)] (3) and [Mn(pbm)(5-nip)3] (4), where H2HIPA = 5-hydroxyisophthalic acid, H2nip = 5-nitroisophthalic acid, H3btc = trimesic acid and pbm (pyridine benzene chelate material) = 2-(2-pyridyl)benzimidazole, were identified via single-crystal XRD analyses. 1, 2 and 4 pertain to the monoclinic space group C2/c, while 3 belongs to the triclinic space group P\begin{document}$ \overline 1 $\end{document}. The interplay of CT-DNA with those complexes was delineated using ultraviolet, fluorescence, and circular dichroism (CD) spectroscopy and viscosity measurements. Complexes 1, 2, 3 and 4 interact with CT-DNA in an electrostatic or grooving mode. We wish to offer a theory-wise foundation for developing anti-tumor medicines.
Synthesis of Highly Luminescent LnMOFs through Structural Regulation
Xiao-Bo YU, Zhao CHEN, Yuan-Jie MA, Ling LI, Wen-Ting CHANG, Bo LI, Cheng-Hui ZENG
2022, 41(3): 2203270-2203276  doi: 10.14102/j.cnki.0254-5861.2021-0013
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Two series of three dimensional (3D) lanthanide metal-organic frameworks (LnMOFs) of [Ln(tftpa)1.5(phen)(H2O)]n (Ln = Sm 1a, Eu 1b, Tb 1c, Dy 1d, H2tftpa = tetrafluoroterephthalic acid, phen = 1, 10-phenanthrolin) and [Ln(tftpa)1.5(bpy)(H2O)]n (Ln = Sm 2a, Eu 2b, Tb 2c, Dy 2d, bpy = 2, 2΄-bipyridine) are obtained by structural regulation. Results reveal that the 3D LnMOFs show high water- and thermal-stability. Interestingly, through selecting the perfluorinated ligand, and using bpy as an auxiliary ligand to hold back the solvents near to the lanthanide ions, 2b, and 2c show high luminescence quantum yield (QY) of 74.50% and 60.03%, respectively. In order to further improve the luminescence QY, the auxiliary ligand of phen with larger conjugation and more rigid structure is synthesized to replace bpy, and fortunately, higher luminescence QY of 80.73% (1b) and 75.17% (1c) are realized.
Synthesis, Crystal Structure, Spectroscopy and Hirshfeld Analysis of 4, 6-Diamino-2-cyclopropylaminopyrimidine-5-carbonitrile with Different Solvents: N, N-dimethylformamide, Methanol and Water
Shu-Wang GE, Bai-Wang SUN
2022, 41(3): 2203277-2203286  doi: 10.14102/j.cnki.0254-5861.2011-3359
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摘要:
Three new solvates of 4, 6-diamino-2-cyclopropylamino-5-pyrimidine carbonitrile (DCL): crystal 1 (DCL with N, N-dimethylformamide (DMF)), crystal 2 (DCL with methanol) and crystal 3 (DCL with water) were synthesized and characterized by single-crystal X-ray diffraction, thermal behaviour, Hirshfeld surface and powder X-ray powder diffraction (PXRD). 1H and 13C NMR spectra confirm solvent molecules existing in the crystal lattice. Crystal 1 forms a 1:1 DCL: DMF crystal; crystal 2 gives a 1:0.5 DCL: methanol crystal and crystal 3 gets a 1:1.5 DCL: H2O crystal. The three crystals are all primarily stabilized by a strong N–H⋅⋅⋅N hydrogen bonding interaction between DCL and the solvents. The structures are stabilized by H⋅⋅⋅H, N–H⋅⋅⋅O, N–H⋅⋅⋅N and O–H⋅⋅⋅O intermolecular interactions. When crystal 2 is dried at 150 ℃, the new polymorph with no solvate is obtained.
A Robust Heterometallic Cd(II)/Ba(II)-Organic Framework with Exposed Amino Group and Active Sites Exhibiting Excellent CO2/CH4 and C2H2/CH4 Separation
Hong-Ru FU, Yu-Ying JIANG, Jia-Hua LUO, Ting LI
2022, 41(3): 2203287-2203292  doi: 10.14102/j.cnki.0254-5861.2011-3340
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摘要:
A microporous and robust bimetal-organic framework [Cd2Ba(NH2-BTB)2]·2(DMA)·2(H2O) (1) was constructed by mixing the heterometallic nodes and an tridentate carboxyl ligand with amino group, benefiting from the synergistic effect of active sites, exposed amino groups and ultramicroporous structure. This compound displays an extraordinary selectivity of CO2/CH4 and C2H2/CH4 (16.7 and 146.3) at 298 K and 1 atm, which can exceed those of many reported MOFs under the same conditions. This work provides an important model to design metal-organic frameworks for the adsorption and separation of small gas molecules.