Citation: Fozia Nazir, Syeda Sundas Musawar, Ashfaq Ahmad Khan, Bilal Akram, Farid Ahmed. Chromogenic and fluorogenic Schiff base sensors[J]. Chinese Journal of Structural Chemistry, ;2025, 44(12): 100751. doi: 10.1016/j.cjsc.2025.100751 shu

Chromogenic and fluorogenic Schiff base sensors

Since their discovery by Hugo Schiff in 1864, Schiff bases and their metal complexes have gained recognition for their catalytic and biological properties. These compounds exhibit diverse functionalities, serving as catalysts in synthetic processes and displaying notable biological activities such as antifungal, antibacterial, anti-malarial, and antiviral effects. In various applications, Schiff bases serve as versatile tools, particularly in sensing applications. Through coordination with various metal ions, they form stable complexes. They are utilized as fluorescent turn-on/turn-off sensors for detecting a wide range of analytes. The coordination ability makes them valuable as chemosensor for detecting environmentally and biologically important analytes. This review provides a thorough overview of Schiff base chemosensors designed for the detection of environmental and biological significance including metal cations, anions, and neutral analytes. It is structured into four focused sections. The first section addresses the use of Schiff base chemosensor for the selective detection of various metal cations, including Ca2+, Al3+, Cr3+, Mn2+, Fe3+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, and Pb2+; The second section examines the application of fluorescent Schiff base sensors in detecting diverse anions such as F−, CN−, I−, and HSO4−; The third section investigates the use of Schiff base fluorescent probes for accurate pH detection and determination; and the fourth section explores the utilization of Schiff base sensors for detecting environmentally and biologically important neutral analytes, including insecticides, pesticides, and others. Additionally, the Schiff base chemosensors for metal cations and anions section are concluded with a table, summarizing the reviewed fluorescent Schiff base sensors for enhanced clarity.
- Environmental monitoring,
- Schiff base,
- Fluorescent sensor,
- Metal cations,
- Anions and neutral species
1. [1]
  Shuangying Li , Qingxiang Zhou , Zhi Li , Menghua Liu , Yanhui Li . Sensitive measurement of silver ions in environmental water samples integrating magnetic ion-imprinted solid phase extraction and carbon dot fluorescent sensor. Chinese Chemical Letters, 2024, 35(5): 108693-. doi: 10.1016/j.cclet.2023.108693
2. [2]
  Jiao Chen , Zihan Zhang , Guojin Sun , Yudi Cheng , Aihua Wu , Zefan Wang , Wenwen Jiang , Fulin Chen , Xiuying Xie , Jianli Li . Benzo[4,5]imidazo[1,2-a]pyrimidine-based structure-inherent targeting fluorescent sensor for imaging lysosomal viscosity and diagnosis of lysosomal storage disorders. Chinese Chemical Letters, 2024, 35(11): 110050-. doi: 10.1016/j.cclet.2024.110050
3. [3]
  Yuanyu YANG , Jianhua XUE , Yujia BAI , Lulu CUI , Dongdong YANG , Qi MA . Design, synthesis, and detection of Al³⁺ of two zinc complexes based on Schiff base ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1207-1216. doi: 10.11862/CJIC.20250005
4. [4]
  Maitri Bhattacharjee , Rekha Boruah Smriti , R. N. Dutta Purkayastha , Waldemar Maniukiewicz , Shubhamoy Chowdhury , Debasish Maiti , Tamanna Akhtar . Synthesis, structural characterization, bio-activity, and density functional theory calculation on Cu(Ⅱ) complexes with hydrazone-based Schiff base ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1409-1422. doi: 10.11862/CJIC.20240007
5. [5]
  Ke Wu , Xiuqin Ruan , Shuolei Jia , Enyuan Wang , Qingfa Zhou . DABCO-catalyzed [3+4] annulations of Schiff bases with α-substituted allenes: Construction of functionalized benzazepine derivatives. Chinese Chemical Letters, 2025, 36(7): 110646-. doi: 10.1016/j.cclet.2024.110646
6. [6]
  Jia-Mei Qin , Xue Li , Wei Lang , Fu-Hao Zhang , Qian-Yong Cao . An AIEgen nano-assembly for simultaneous detection of ATP and H₂S. Chinese Chemical Letters, 2024, 35(6): 108925-. doi: 10.1016/j.cclet.2023.108925
7. [7]
  Yijian Zhao , Jvzhe Li , Yunyi Shi , Jie Hu , Meiyi Liu , Yao Shen , Xinglin Hou , Qiuyue Wang , Qi Wang , Zhiyi Yao . A label-free and ratiometric fluorescent sensor based on porphyrin-metal-organic frameworks for sensitive detection of ochratoxin A in cereal. Chinese Chemical Letters, 2025, 36(4): 110132-. doi: 10.1016/j.cclet.2024.110132
8. [8]
  Jia-He Li , Yu-Ze Liu , Jia-Hui Ma , Qing-Xiao Tong , Jian-Ji Zhong , Jing-Xin Jian . 洛芬碱衍生物的合成、化学发光与重金属离子检测. University Chemistry, 2025, 40(6): 230-237. doi: 10.12461/PKU.DXHX202407080
9. [9]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
10. [10]
  Xiaotong LU , Pan ZHANG , Zijie ZHAO , Lei HUANG , Hongwei ZUO , Lili LIANG . Antitumor and antibacterial activities of pyridyl Schiff base indium and dysprosium complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(8): 1523-1532. doi: 10.11862/CJIC.20250073
11. [11]
  Li Li , Lin-Lin Zhang , Yansha Gao , Lu-Ying Duan , Wuying Yang , Xigen Huang , Yanping Hong , Jiaxin Hong , Lin Yuan , Limin Lu . Target self-calibration ratiometric fluorescent sensor based on facile-synthesized europium metal-organic framework for multi-color visual detection of levofloxacin. Chinese Chemical Letters, 2025, 36(7): 110436-. doi: 10.1016/j.cclet.2024.110436
12. [12]
  Tao Yu , Vadim A. Soloshonok , Zhekai Xiao , Hong Liu , Jiang Wang . Probing the dynamic thermodynamic resolution and biological activity of Cu(Ⅱ) and Pd(Ⅱ) complexes with Schiff base ligand derived from proline. Chinese Chemical Letters, 2024, 35(4): 108901-. doi: 10.1016/j.cclet.2023.108901
13. [13]
  Xiaofen GUAN , Yating LIU , Jia LI , Yiwen HU , Haiyuan DING , Yuanjing SHI , Zhiqiang WANG , Wenmin WANG . Synthesis, crystal structure, and DNA-binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2486-2496. doi: 10.11862/CJIC.20240122
14. [14]
  Yingyue ZHANG , Liuqing KANG , Yating YANG , Xiaofen GUAN , Wenmin WANG . Crystal structure and antibacterial activity of two Gd₂ complexes based on polydentate Schiff-base ligands. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1867-1877. doi: 10.11862/CJIC.20250100
15. [15]
  Shengyi Gong , Guoqiang Feng . Visible light-triggered NIR ratiometric fluorescent metal-free CO-releasing molecule for self-monitoring of CO delivery and effective cancer therapy. Chinese Chemical Letters, 2025, 36(7): 110409-. doi: 10.1016/j.cclet.2024.110409
16. [16]
  Kezuo Di , Jie Wei , Lijun Ding , Zhiying Shao , Junling Sha , Xilong Zhou , Huadong Heng , Xujing Feng , Kun Wang . A wearable sensor device based on screen-printed chip with biofuel cell-driven electrochromic display for noninvasive monitoring of glucose concentration. Chinese Chemical Letters, 2025, 36(2): 109911-. doi: 10.1016/j.cclet.2024.109911
17. [17]
  Fan Zheng , Runsha Xiao , Shuai Huang , Zhikang Chen , Chen Lai , Anyao Bi , Heying Yao , Xueping Feng , Zihua Chen , Wenbin Zeng . Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe. Chinese Chemical Letters, 2025, 36(2): 109876-. doi: 10.1016/j.cclet.2024.109876
18. [18]
  Shuwen SUN , Gaofeng WANG . Design and synthesis of a Zn(Ⅱ)-based coordination polymer as a fluorescent probe for trace monitoring 2, 4, 6-trinitrophenol. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 753-760. doi: 10.11862/CJIC.20240399
19. [19]
  Baoli Yin , Xinlin Liu , Zhe Li , Zhifei Ye , Youjuan Wang , Xia Yin , Sulai Liu , Guosheng Song , Shuangyan Huan , Xiao-Bing Zhang . Ratiometric NIR-Ⅱ fluorescent organic nanoprobe for imaging and monitoring tumor-activated photodynamic therapy. Chinese Chemical Letters, 2025, 36(5): 110119-. doi: 10.1016/j.cclet.2024.110119
20. [20]
  Chengcheng Zhang , Zhe Wu , Ningning Jiang , Yi Song , Weina Geng , Hongmei Liu , Ming Jin , Shuxiang Wang , Jinchao Zhang , Yutao Yang . A fluorescent probe regulated by trifluoromethyl and nitrogen-containing heterocycles for monitoring biothiol fluctuations in the brains of mice with schizophrenia. Chinese Chemical Letters, 2026, 37(1): 111476-. doi: 10.1016/j.cclet.2025.111476

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沈阳化工大学材料科学与工程学院沈阳 110142