Citation: Fei Yao, Yifan Fan, Bing-Feng Shi, Tao Tu. Direct and enantioselective acylation of diverse C(sp³)−H bonds with aldehydes[J]. Chinese Chemical Letters, ;2026, 37(11): 112994. doi: 10.1016/j.cclet.2026.112994 shu

Direct and enantioselective acylation of diverse C(sp³)−H bonds with aldehydes

Fei Yao ^a ,
Yifan Fan ^{b, *,} ,
Bing-Feng Shi ^{a, c, *,} ,
Tao Tu ^{b, d, *,}

a.
State Key Laboratory of Soil Pollution Control and Safety, Department of Chemistry, Zhejiang University, Hangzhou 310058, China
b.
State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China
c.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China
d.
Zhejiang Key Laboratory of Extreme Environment Functional Materials, Yiwu Research Institute of Fudan University, Yiwu 322000, China

fanyifan@nxu.edu.cn

bfshi@zju.edu.cn

taotu@fudan.edu.cn

Received Date: 25 April 2026
Accepted Date: 22 May 2026
Available Online: 24 May 2026

Figures(2)

1. [1]
  C.L. Joe, A.G. Doyle, Angew. Chem. Int. Ed. 55 (2016) 4040–4043. doi: 10.1002/anie.201511438
2. [2]
  L. Huan, X. Shu, W. Zu, D. Zhong, H. Huo, Nat. Commun. 12 (2021) 3536–3543.
3. [3]
  H. Cao, X. Tang, H. Tang, Y. Yuan, J. Wu, Chem Catal. 1 (2021) 523–598.
4. [4]
  T. Li, Z. Xu, Y. Huang, W. Zu, H. Huo, J. Am. Chem. Soc. 147 (2025) 10999–11009. doi: 10.1021/jacs.4c15275
5. [5]
  T. Kawasaki, N. Ishida, M. Murakami, J. Am. Chem. Soc. 142 (2020) 3366–3370. doi: 10.1021/jacs.9b13920
6. [6]
  M. Chen, A.M. Ventura, S. Das, et al., J. Am. Chem. Soc. 145 (2023) 20176–20181. doi: 10.1021/jacs.3c06532
7. [7]
  Z. Zhou, F. Hu, X. Lin, Y. Ping, W. Kong, J. Am. Chem. Soc. 148 (2026) 7113–7123. doi: 10.1021/jacs.5c18382
1. [1]
  Yuemin Chen , Yunqi Wu , Guoao Wang , Feihu Cui , Haitao Tang , Yingming Pan . Electricity-driven enantioselective cross-dehydrogenative coupling of two C(sp³)-H bonds enabled by organocatalysis. Chinese Chemical Letters, 2024, 35(9): 109445-. doi: 10.1016/j.cclet.2023.109445
2. [2]
  Xin-Han Wang , Ying Huang , Chun-Lin Zhang , Song Ye . γ-C(sp³)-H acylation of aliphatic amines enabled by cooperative photoredox NHC/Pd catalysis. Chinese Chemical Letters, 2026, 37(5): 111484-. doi: 10.1016/j.cclet.2025.111484
3. [3]
  Yujia Shi , Yan Qiao , Pengfei Xie , Miaomiao Tian , Xingwei Li , Junbiao Chang , Bingxian Liu . Rhodium-catalyzed enantioselective in situ C(sp³)−H heteroarylation by a desymmetrization approach. Chinese Chemical Letters, 2024, 35(10): 109544-. doi: 10.1016/j.cclet.2024.109544
4. [4]
  Xiu-Mei Xie , Hongyang Zhang , Shao-Xuan Gong , Hong-Xia Sun , Yu-Ting Liu , Xue-Ling Chen , Shuming Chen , Tian-Yu Gao , Wai-Yeung Wong , Zhen Zhang , Da-Gang Yu . Carbonylation of C(sp³)–H bonds with CO₂: Facile synthesis of 2,4-quinolinediones and related luminescent materials. Chinese Chemical Letters, 2026, 37(3): 112003-. doi: 10.1016/j.cclet.2025.112003
5. [5]
  Nana Ma , Qiongjin Wang , Die Zhao , Bowen Duan , Dihao Kang , Shujun Li . Mechanistic insights into copper-mediated dehydroboration of alkane C(sp³)-H bonds: Triple roles of CuCl₂. Chinese Chemical Letters, 2026, 37(11): 112356-. doi: 10.1016/j.cclet.2025.112356
6. [6]
  Lei Wan , Yizhou Tong , Xi Lu , Yao Fu . Cobalt-catalyzed reductive alkynylation to construct C(sp)-C(sp³) and C(sp)-C(sp²) bonds. Chinese Chemical Letters, 2024, 35(7): 109283-. doi: 10.1016/j.cclet.2023.109283
7. [7]
  Jun Jiang , Hui Dai , Tao Tu . Two vicinal C(sp³)-F bonds functionalization of perfluoroalkyl halides (PFAHs). Chinese Chemical Letters, 2025, 36(7): 111054-. doi: 10.1016/j.cclet.2025.111054
8. [8]
  Tong Li , Leping Pan , Yan Zhang , Jihu Su , Kai Li , Kuiliang Li , Hu Chen , Qi Sun , Zhiyong Wang . Electrochemical construction of 2,5-diaryloxazoles via N–H and C(sp³)-H functionalization. Chinese Chemical Letters, 2024, 35(4): 108897-. doi: 10.1016/j.cclet.2023.108897
9. [9]
  Haoran Shi , Jiaxin Wang , Yuqin Zhu , Hongyang Li , Guodong Ju , Lanlan Zhang , Chao Wang . Highly selective α-C(sp³)-H arylation of alkenyl amides via nickel chain-walking catalysis. Chinese Chemical Letters, 2024, 35(7): 109333-. doi: 10.1016/j.cclet.2023.109333
10. [10]
  Jian Han , Li-Li Zeng , Qin-Yu Fei , Yan-Xiang Ge , Rong-Hui Huang , Fen-Er Chen . Recent advances in remote C(sp³)–H functionalization via chelating group-assisted metal-catalyzed chain-walking reaction. Chinese Chemical Letters, 2024, 35(11): 109647-. doi: 10.1016/j.cclet.2024.109647
11. [11]
  Jialin Huang , Liying Fu , Zhanyong Tang , Xiaoqiang Ma , Xingda Zhao , Depeng Zhao . Cross-coupling of trifluoromethylarenes with alkynes C(sp)-H bonds and azoles C(sp²)-H bonds via photoredox/copper dual catalysis. Chinese Chemical Letters, 2025, 36(7): 110505-. doi: 10.1016/j.cclet.2024.110505
12. [12]
  Jing Ren , Feng-Huan Du , Xiaowei Chen , Chi Zhang . Monofluoroiodane(Ⅲ) reagent mediated Wagner−Meerwein rearrangement fluorination: Construction of quaternary C(sp³)−F bond. Chinese Chemical Letters, 2026, 37(5): 111407-. doi: 10.1016/j.cclet.2025.111407
13. [13]
  Huai-Gui Li , Can-Ming Zhu , Weidong Yuan , Hongyi Chen , Zhengyuan Bo , Chao Deng , Yingguang Zhu , Kang Chen , Qing-Yuan Meng . Stereodivergent reductive C(sp²)-C(sp³) coupling between cycloketone oximes and vinyl halides enabled by tunable photoredox/Ti dual catalysis. Chinese Chemical Letters, 2026, 37(7): 111941-. doi: 10.1016/j.cclet.2025.111941
14. [14]
  Changming Li , Hongdan Zhu , Can-Can Bao , Yongjia Lin , Bing-Tao Guan , Qian Peng . Mechanistic insights for Aryl dilithium base enables the acylation of unactivated C_sp3–H. Chinese Chemical Letters, 2025, 36(9): 110809-. doi: 10.1016/j.cclet.2024.110809
15. [15]
  Pan Gao , Qingzheng Kong , Ying Sun , Qian Ma , Qi Wang , Zeyu Guo , Ledi Li , Bingbing Li , Jingwei Xu , Xiaomei Jiang , Zhaolai Chen . One-dimensional (C12H12N)3Cu3I6 for high-performance direct X-ray detection. Chinese Journal of Structural Chemistry, 2026, 45(1): 100767-100767. doi: 10.1016/j.cjsc.2025.100767
16. [16]
  Jianing Zhang , Weitao Guo , Chaoyang Li , Rongyu Yan , Yunlong Qin , Yang Zhao , Yong-Yuan Gui , Lili Zhao , Qilin Wang . Direct transformation of azaarenes into aromatic aldehydes and QUINAP-like atropisomers. Chinese Chemical Letters, 2026, 37(8): 112017-. doi: 10.1016/j.cclet.2025.112017
17. [17]
  Xinghao Cai , Chen Ma , Ying Kang , Yuqiang Ren , Xue Meng , Wei Lu , Shiming Fan , Shouxin Liu . Nickel-catalyzed C(sp²)–H alkynylation of free α-substituted benzylamines using a transient directing group. Chinese Chemical Letters, 2025, 36(10): 110901-. doi: 10.1016/j.cclet.2025.110901
18. [18]
  Chaoyu Wang , Xiuling Cui . Catalytic enantioselective synthesis of planar-chiral cyclophanes via chiral octahedral cobalt(Ⅲ)-templated C−H macrocyclization. Chinese Chemical Letters, 2026, 37(8): 112527-. doi: 10.1016/j.cclet.2026.112527
19. [19]
  Mengyao Yuan , Wansen Xie , Xiaoyu Yang . Enantioselective synthesis of inherently chiral calix[4]arenes via asymmetric C-H bromination of phenols. Chinese Chemical Letters, 2026, 37(9): 112157-. doi: 10.1016/j.cclet.2025.112157
20. [20]
  Yi Luo , Lin Dong . Multicomponent remote C(sp²)-H bond addition by Ru catalysis: An efficient access to the alkylarylation of 2H-imidazoles. Chinese Chemical Letters, 2024, 35(10): 109648-. doi: 10.1016/j.cclet.2024.109648