Citation: Xiao-Kang Dai, Jia-Xin Xiong, Zheng-Yan Wang, Hao-Dong Qian, Jing Zhao, Shaolin Zhou, Hao Xu. Remote copper-catalyzed asymmetric [4 + 1] annulation of yne-thienyl esters with 1,3-dicarbonyls[J]. Chinese Chemical Letters, ;2026, 37(10): 112870. doi: 10.1016/j.cclet.2026.112870 shu

Remote copper-catalyzed asymmetric [4 + 1] annulation of yne-thienyl esters with 1,3-dicarbonyls

Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, Ministry of Education, State Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China

szhou@ccnu.edu.cn

hao.xu@ccnu.edu.cn

Received Date: 6 January 2026
Revised Date: 26 April 2026
Accepted Date: 30 April 2026
Available Online: 1 May 2026

Figures(4)

The copper-catalyzed enantioselective [4 + 1] annulation of yne-thienyl esters with 1,3-dicarbonyl compounds was realized through an elegant remote stereocontrol strategy. Greatly diverse spirocycles were obtained in moderate to good yields with excellent stereochemical control. Moreover, preliminary mechanistic studies suggest an remote substitution and Conia-ene cascade pathway on the remote stereochemical induction progress.
- Copper catalysis,
- Enantioselective [4 + 1] annulation,
- Yne-thienyl esters,
- Remote stereochemistry
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