Citation: Na Lin, Lu Zou, Yitan Fang, Jinya Xiong, Qiuling Deng, Zefang Liu, Xueyi Hao, Qinfu Zhao, Xiaofan Wang, Long Wan. Advances in carbon-based nanozymes for photothermal-enhanced tumor theranostics[J]. Chinese Chemical Letters, ;2026, 37(10): 112585. doi: 10.1016/j.cclet.2026.112585 shu

Advances in carbon-based nanozymes for photothermal-enhanced tumor theranostics

Na Lin ^{a, 1} ,
Lu Zou ^{b, 1} ,
Yitan Fang ^{c, 1} ,
Jinya Xiong ^d ,
Qiuling Deng ^d ,
Zefang Liu ^f ,
Xueyi Hao ^f ,
Qinfu Zhao ^{d, *,} ,
Xiaofan Wang ^{e, g, *,} ,
Long Wan ^{f, g, *,}

a.
Department of Hematology, The First Hospital of China Medical University, Shenyang 110001, China
b.
Department of Cardiology, The First Hospital of China Medical University, Shenyang 110001, China
c.
Department of Cardiac Surgery, The First Hospital of China Medical University, Shenyang 110001, China
d.
Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
e.
Department of Pharmacy, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
f.
Department of Pharmacy, The First Hospital of China Medical University, Shenyang 110001, China
g.
School of Pharmacy, China Medical University, Shenyang 110122, China

qinfuzhao@syphu.edu.cn

xfwang@cmu.edu.cn

longwan@cmu.edu.cn

Received Date: 23 November 2025
Revised Date: 3 March 2026
Accepted Date: 5 March 2026
Available Online: 8 March 2026

Figures(3)

Nanozymes have been widely used in tumor theranostics because of their enzyme-like catalytic properties and the ease of preparation and stability, which are superior to those of natural enzymes. The complex tumor microenvironment limits the therapeutic efficacy in various ways, while carbon-based nanozymes stand out among the nanozymes due to their high specific surface area, strong drug-carrying capacity, easy-to-modify surfaces, excellent biocompatibility, and unique optical-photothermal conversion efficiency. In recent years, significant progress has been made in the application of carbon nanozymes (CNs) in tumor therapy. This article mainly reviews the classification, characteristics, catalytic mechanism and the latest applications of CNs in tumor theranostics. Additionally, it analyzes the prospects and challenges faced by CNs.
- Carbon-based nanozymes,
- Enzyme-like activity,
- Photothermal therapy,
- Synergistic therapy,
- Tumor theranostics
1. [1]
  J. Lu, L. Cai, Y. Dai, et al., Chem. Rec. 21 (2021) 781–796. doi: 10.1002/tcr.202000170
2. [2]
  K. Qi, B. Sun, S.Y. Liu, et al., Biomed. Pharmacother. 165 (2023) 115070. doi: 10.1016/j.biopha.2023.115070
3. [3]
  T. Zhang, J. Wu, Z. Tang, et al., Mater. Chem. Front. 7 (2023) 2359–2372. doi: 10.1039/d3qm00043e
4. [4]
  Y.W. Chen, Y.L. Su, S.H. Hu, et al., Adv. Drug Deliv. Rev. 105 (2016) 190–204. doi: 10.5539/ass.v12n10p190
5. [5]
  M.S. Kang, H. Lee, S.J. Jeong, et al., Biomedicines 10 (2022) 1374. doi: 10.3390/biomedicines10061374
6. [6]
  K.D. Patel, R.K. Singh, H.W. Kim, Mater. Horiz. 6 (2019) 434–469. doi: 10.1039/c8mh00966j
7. [7]
  L. Tang, Q. Xiao, Y. Mei, et al., J. Nanobiotechnol. 19 (2021) 423. doi: 10.1186/s12951-021-01174-y
8. [8]
  M.M. Hussain, W.U. Khan, F. Ahmed, et al., Chem. Eng. J. 465 (2023) 143010. doi: 10.1016/j.cej.2023.143010
9. [9]
  Y. He, C. Hu, Z. Li, et al., Mater. Today Bio 14 (2022) 100231. doi: 10.1016/j.mtbio.2022.100231
10. [10]
  X. Ding, Z. Zhao, Y. Zhang, et al., Small 19 (2023) 2207142. doi: 10.1002/smll.202207142
11. [11]
  W.D. Gao, Y.Q. Mu, L. Xiao, et al., Eur. Cells Mater. 52 (2025) 80–97. doi: 10.22203/ecm.v052a06
12. [12]
  H. Fu, Y. Wang, B. Huang, et al., J. Control. Release 380 (2025) 892–909. doi: 10.1016/j.jconrel.2025.02.038
13. [13]
  Y. Wang, H. Fu, B. Huang, et al., Chem. Eng. J. 497 (2024) 155684. doi: 10.1016/j.cej.2024.155684
14. [14]
  N.M. Phan, T.L. Nguyen, J. Kim, Tissue Eng. Regen. Med. 19 (2022) 237–252. doi: 10.1007/s13770-022-00430-y
15. [15]
  R.M. Joshi, B. Telang, G. Soni, et al., Oncol. Transl. Med. 10 (2024) 105–109.
16. [16]
  D. Zhang, X. Cai, Y. Li, et al., Chin. Chem. Lett. 37 (2026) 111569. doi: 10.1016/j.cclet.2025.111569
17. [17]
  X. Cai, Q. Zheng, Y. Wu, et al., Chin. Chem. Lett. 37 (2026) 111670. doi: 10.1016/j.cclet.2025.111670
18. [18]
  M. Bacon, S.J. Bradley, T. Nann, Part. Part. Syst. Charact. 31 (2014) 415–428. doi: 10.1002/ppsc.201300252
19. [19]
  S. Khan, A. Dunphy, M.S. Anike, et al., Int. J. Mol. Sci. 22 (2021) 6786. doi: 10.3390/ijms22136786
20. [20]
  B. Garg, T. Bisht, Molecules 21 (2016) 1653. doi: 10.3390/molecules21121653
21. [21]
  F. Ostadhossein, D. Pan, Wiley Interdiscip, Rev. Nanomed. Nanobiotechnol. 9 (2017) e1436. doi: 10.1002/wnan.1436
22. [22]
  B. Geng, L. Yan, Y. Zhu, et al., Adv. Healthc. Mater. 12 (2023) 2202154. doi: 10.1002/adhm.202202154
23. [23]
  X. Chu, P. Zhang, Y. Liu, et al., J. Mater. Chem. B 10 (2022) 2865–2874. doi: 10.1039/d1tb02717d
24. [24]
  W. Chao, Y. Li, X. Sun, et al., Chem. Eng. J. 405 (2021) 126703. doi: 10.1016/j.cej.2020.126703
25. [25]
  Y.W. Bao, X.W. Hua, Y.H. Li, et al., ACS Appl. Mater. Interfaces 10 (2018) 1544–1555. doi: 10.1021/acsami.7b15332
26. [26]
  N. Gharbi, M. Pressac, M. Hadchouel, et al., Nano Lett. 5 (2005) 2578–2585. doi: 10.1021/nl051866b
27. [27]
  A. Chen, S.R. Grobmyer, V.B. Krishna, ACS Omega 5 (2020) 14444–14450. doi: 10.1021/acsomega.0c01018
28. [28]
  R. Kawasaki, K. Kondo, R. Miura, et al., Int. J. Mol. Sci. 23 (2022) 4686. doi: 10.3390/ijms23094686
29. [29]
  Y. Zhou, M. Zhen, M. Guan, et al., Sci. Rep. 8 (2018) 16573. doi: 10.1038/s41598-018-34967-7
30. [30]
  Y. Zhou, J. Li, H. Ma, et al., ACS Appl. Mater. Interfaces 9 (2017) 35539–35547. doi: 10.1021/acsami.7b08348
31. [31]
  L. Li, J. Fu, J. Ye, et al., Adv. Mater. 36 (2024) 2310875. doi: 10.1002/adma.202310875
32. [32]
  Y.S. Youn, D.S. Kwag, E.S. Lee, J. Pharm. Investig. 47 (2017) 1–10. doi: 10.1007/s40005-016-0282-8
33. [33]
  B. Gorain, H. Choudhury, M. Pandey, et al., Biomed. Pharmacother. 104 (2018) 496–508. doi: 10.1016/j.biopha.2018.05.066
34. [34]
  A. Galano, Nanoscale 2 (2010) 373–380. doi: 10.1039/b9nr00364a
35. [35]
  V. Negri, J. Pacheco-Torres, D. Calle, P. López–Larrubia, Carbon nanotubes in biomedicine, in: A.R. Puente-Santiago, D. Rodríguez-Padrón (Eds.), Surface–Modified Nanobiomaterials for Electrochemical and Biomedicine Applications, Springer International Publishing, Cham, 2020, pp. 177–217.
36. [36]
  Q. Wang, X. Zhu, B. Yin, et al., Adv. Funct. Mater. 34 (2024) 2408141. doi: 10.1002/adfm.202408141
37. [37]
  H.A. Hassan, S.S. Diebold, L.A. Smyth, et al., J. Control. Release 297 (2019) 79–90. doi: 10.1016/j.jconrel.2019.01.017
38. [38]
  D. Maiti, X. Tong, X. Mou, et al., Front. Pharmacol. 9 (2019) 1401. doi: 10.3389/fphar.2018.01401
39. [39]
  T.M. Magne, T. de Oliveira Vieira, L.M.R. Alencar, et al., J. Nanostruct. Chem. 12 (2021) 693–727.
40. [40]
  Y. Wang, J. Li, X. Li, et al., Bioact. Mater. 14 (2022) 335–349.
41. [41]
  D.P. Singh, C.E. Herrera, B. Singh, et al., Mater. Sci. Eng. C 86 (2018) 173–197. doi: 10.1016/j.msec.2018.01.004
42. [42]
  Z. Youssef, R. Vanderesse, L. Colombeau, et al., Cancer Nanotechnol. 8 (2017) 6. doi: 10.1186/s12645-017-0032-2
43. [43]
  Z. Liu, J.T. Robinson, X. Sun, et al., J. Am. Chem. Soc. 130 (2008) 10876–10877. doi: 10.1021/ja803688x
44. [44]
  G. Ban, Y. Hou, Z. Shen, et al., Int. J. Nanomedicine 18 (2023) 1695–1708. doi: 10.2147/ijn.s402954
45. [45]
  M.G. Burdanova, M.V. Kharlamova, C. Kramberger, et al., Nanomaterials 11 (2021) 3020. doi: 10.3390/nano11113020
46. [46]
  A.M. Itoo, S.L. Vemula, M.T. Gupta, et al., J. Control. Release 350 (2022) 26–59. doi: 10.1016/j.jconrel.2022.08.011
47. [47]
  J. Jampilek, K. Kralova, Int. J. Mol. Sci. 23 (2022) 6253. doi: 10.3390/ijms23116253
48. [48]
  J. Li, H. Zeng, Z. Zeng, et al., ACS Biomater. Sci. Eng. 7 (2021) 5363–5396. doi: 10.1021/acsbiomaterials.1c00875
49. [49]
  Z. Yang, M. Yuan, B. Liu, et al., Adv. Mater. 37 (2025) 2412069. doi: 10.1002/adma.202412069
50. [50]
  S. Feng, J. Wang, X. Mu, et al., Colloids Surf. B: Biointerfaces 222 (2023) 113095. doi: 10.1016/j.colsurfb.2022.113095
51. [51]
  Y. Kuang, Y. Cao, M. Liu, et al., ACS Appl. Mater. Interfaces 10 (2018) 26099–26107. doi: 10.1021/acsami.8b09709
52. [52]
  J. Zhou, W. Wang, Q. Zhang, et al., Chem. Sci. 13 (2022) 6967–6981. doi: 10.1039/d2sc01740g
53. [53]
  M.M. Rahman, M.G. Ara, M.A. Alim, et al., Int. J. Mol. Sci. 22 (2021) 4498. doi: 10.3390/ijms22094498
54. [54]
  L.M. Russell, C.H. Liu, P. Grodzinski, Biomaterials 242 (2020) 119926. doi: 10.1016/j.biomaterials.2020.119926
55. [55]
  X. Song, C. Zhang, M. Xing, et al., J. Mater. Chem. B 11 (2023) 6147–6158. doi: 10.1039/d3tb00595j
56. [56]
  L. Yang, S. Dong, S. Gai, et al., Nano-Micro Lett. 16 (2023) 28.
57. [57]
  X. Shen, Z. Wang, X.J. Gao, et al., Adv. Mater. 36 (2023) e2211151.
58. [58]
  J. Lin, Z. Sun, Y. Huang, et al., Chem. Eng. J. 507 (2025) 160181. doi: 10.1016/j.cej.2025.160181
59. [59]
  H. Sun, A. Zhao, N. Gao, et al., Angew. Chem. Int. Ed. 54 (2015) 7176–7180. doi: 10.1002/anie.201500626
60. [60]
  M. Lyu, M. Luo, J. Li, et al., Adv. Funct. Mater. 33 (2023) 2306930. doi: 10.1002/adfm.202306930
61. [61]
  T. Luo, H. Yang, R. Wang, et al., ACS Nano 17 (2023) 16715–16730. doi: 10.1021/acsnano.3c03169
62. [62]
  L. Song, Q. Zhao, S. Feng, et al., Adv. Funct. Mater. 35 (2024) 2414121.
63. [63]
  A. Wibrianto, G. Getachew, W.B. Dirersa, et al., Carbon 208 (2023) 191–207. doi: 10.1016/j.carbon.2023.03.052
64. [64]
  Y. Jiang, C. Glandorff, M. Sun, Antioxidants 13 (2024) 697. doi: 10.3390/antiox13060697
65. [65]
  H. Imai, M. Matsuoka, T. Kumagai, et al., The Future of HIV-1 Therapeutics, Springer, Cham, 2017.
66. [66]
  L. Yao, M.M. Zhao, Q.W. Luo, et al., ACS Nano 16 (2022) 9228–9239. doi: 10.1021/acsnano.2c01619
67. [67]
  A.M. Eaqub, R.M. Motiar, S.S. M, et al., J. Nanomater. 2014 (2014) 192038. doi: 10.1155/2014/192038
68. [68]
  Y. Zheng, M. Du, H. Shi, et al., Chem. Eng. J. 472 (2023) 144952. doi: 10.1016/j.cej.2023.144952
69. [69]
  Y. Zhu, W. Wang, J. Cheng, et al., Angew. Chem. Int. Ed. 60 (2021) 9480–9488. doi: 10.1002/anie.202017152
70. [70]
  W. Wang, Y. Zhu, X. Zhu, et al., ACS Appl. Mater. Interfaces 13 (2021) 45269–45278. doi: 10.1021/acsami.1c12706
71. [71]
  X. Zhang, X. Chen, Y. Zhao, Nano-Micro Lett. 14 (2022) 95. doi: 10.1007/s40820-022-00828-2
72. [72]
  Y. Li, J. Lu, J. Zhang, et al., ACS Appl. Bio Mater. 3 (2020) 8705–8713. doi: 10.1021/acsabm.0c01102
73. [73]
  Y. Yang, D. Zhu, Y. Liu, et al., Nanoscale 12 (2020) 13548–13557. doi: 10.1039/d0nr02800b
74. [74]
  D. Zhao, Y. Deng, J. Shi, et al., Int. J. Biol. Macromol. 276 (2024) 133963. doi: 10.1016/j.ijbiomac.2024.133963
75. [75]
  M. Kepinska, R. Kizek, H.J. Milnerowicz, Int. J. Mol. Sci. 19 (2018) 3253. doi: 10.3390/ijms19103253
76. [76]
  P. Muhammad, S. Hanif, J. Li, et al., Nano Today 45 (2022) 101530. doi: 10.1016/j.nantod.2022.101530
77. [77]
  D. Guo, R. Shibuya, C. Akiba, et al., Science 351 (2016) 361–365. doi: 10.1126/science.aad0832
78. [78]
  K. Fan, J. Xi, L. Fan, et al., Nat. Commun. 9 (2018) 1440. doi: 10.1038/s41467-018-03903-8
79. [79]
  Z. Wang, R. Zhang, X. Yan, et al., Mater. Today 41 (2020) 81–119. doi: 10.1016/j.mattod.2020.08.020
80. [80]
  H. Ding, B. Hu, B. Zhang, et al., Nano Res. 14 (2020) 570–583.
81. [81]
  Y. Chen, L. Jiao, H. Yan, et al., Anal. Chem. 92 (2020) 13518–13524. doi: 10.1021/acs.analchem.0c02982
82. [82]
  R. Zeng, Y. Li, X. Hu, et al., Nano Lett. 23 (2023) 6073–6080. doi: 10.1021/acs.nanolett.3c01454
83. [83]
  Y. Sun, B. Xu, X. Pan, et al., Coord. Chem. Rev. 475 (2023) 214896. doi: 10.1016/j.ccr.2022.214896
84. [84]
  A.X. Zheng, Z.X. Cong, J.R. Wang, et al., Biosens. Bioelectron. 49 (2013) 519–524. doi: 10.1016/j.bios.2013.05.038
85. [85]
  Y. Zhang, C. Wu, X. Zhou, et al., Nanoscale 5 (2013) 1816–1819. doi: 10.1039/c3nr33954h
86. [86]
  X. Dang, H. Zhao, Talanta 210 (2020) 120678. doi: 10.1016/j.talanta.2019.120678
87. [87]
  S. Zhong, Z. Zhang, Y. Zhao, et al., Nanoscale 15 (2023) 16619–16625. doi: 10.1039/d3nr03957a
88. [88]
  N.S. Heo, H.P. Song, S.M. Lee, et al., Microchim. Acta 187 (2020) 286. doi: 10.1007/s00604-020-04249-z
89. [89]
  H. Sun, Y. Zhou, J. Ren, et al., Angew. Chem. Int. Ed. 57 (2018) 9224–9237. doi: 10.1002/anie.201712469
90. [90]
  Y. Tao, Y. Lin, Z. Huang, et al., Adv. Mater. 25 (2013) 2594–2599. doi: 10.1002/adma.201204419
91. [91]
  L. Lin, X. Song, Y. Chen, et al., Anal. Chim. Acta 869 (2015) 89–95. doi: 10.1016/j.aca.2015.02.024
92. [92]
  J. Zhang, J. Liu, Luminescence 35 (2020) 1185–1194. doi: 10.1002/bio.3893
93. [93]
  A.R. Sureshbabu, R. Kurapati, J. Russier, et al., Biomaterials 72 (2015) 20–28. doi: 10.1016/j.biomaterials.2015.08.046
94. [94]
  K. Adachi, Y. Tsukahara, Curr. Opin. Chem. Eng. 11 (2016) 106–113. doi: 10.1016/j.coche.2016.01.002
95. [95]
  M. Jin, Z. Liang, Y. Huang, et al., J. Am. Chem. Soc. 146 (2024) 34092–34106. doi: 10.1021/jacs.4c13573
96. [96]
  W.D. Joo, I. Visintin, G. Mor, Maturitas 76 (2013) 308–314. doi: 10.1016/j.maturitas.2013.09.008
97. [97]
  Q. Liu, Q. Liao, Y. Zhao, Cancer Cell Int. 17 (2017) 68. doi: 10.1186/s12935-017-0437-3
98. [98]
  G. Housman, S. Byler, S. Heerboth, et al., Cancers 6 (2014) 1769–1792. doi: 10.3390/cancers6031769
99. [99]
  W.Q. Lim, G. Yang, S.Z.F. Phua, et al., ACS Appl. Mater. Interfaces 11 (2019) 16391–16401. doi: 10.1021/acsami.9b04557
100. [100]
  F. Zhou, M. Wang, T. Luo, et al., Biomaterials 265 (2021) 120421. doi: 10.1016/j.biomaterials.2020.120421
101. [101]
  M. Lu, J. Ding, Y. Zhang, et al., Int. J. Biol. Macromol. 283 (2024) 137776. doi: 10.1016/j.ijbiomac.2024.137776
102. [102]
  Z. Meng, X. Zhou, J. Xu, et al., Adv. Mater. 31 (2019) 1900927. doi: 10.1002/adma.201900927
103. [103]
  W. Jiang, Q. Li, L. Xiao, et al., ACS Nano 12 (2018) 5684–5698. doi: 10.1021/acsnano.8b01508
104. [104]
  S.Y. Guo, D. Sun, D.L. Ni, et al., Adv. Funct. Mater. 30 (2020) 2000486. doi: 10.1002/adfm.202000486
105. [105]
  T.D. Eubank, R.D. Roberts, M. Khan, et al., Cancer Res. 69 (2009) 2133–2140.
106. [106]
  Y. Liu, W. Zhen, L. Jin, et al., ACS Nano 12 (2018) 4886–4893. doi: 10.1021/acsnano.8b01893
107. [107]
  S. Cai, J. Liu, J. Ding, et al., Angew. Chem. Int. Ed. 61 (2022) e202204502. doi: 10.1002/anie.202204502
108. [108]
  A.K. Shukla, S. Randhawa, T.C. Saini, et al., Int. J. Biol. Macromol. 233 (2023) 123466. doi: 10.1016/j.ijbiomac.2023.123466
109. [109]
  K. Xu, X. Wu, Y. Cheng, et al., Nanoscale 12 (2020) 23159–23165. doi: 10.1039/d0nr05097k
110. [110]
  N. Wang, T. Dong, W. Shi, et al., J. Mater. Chem. B 11 (2023) 6372–6382. doi: 10.1039/d3tb00254c
111. [111]
  Q. Miao, K. Pu, Adv. Mater. 30 (2018) 1801778. doi: 10.1002/adma.201801778
112. [112]
  D. Zhu, M. Lyu, Q. Huang, et al., ACS Appl. Mater. Interfaces 12 (2020) 36928–36937. doi: 10.1021/acsami.0c09969
113. [113]
  Y. Liu, P. Bhattarai, Z. Dai, et al., Chem. Soc. Rev. 48 (2019) 2053–2108. doi: 10.1039/C8CS00618K
114. [114]
  L. Jiao, H. Yan, Y. Wu, et al., Angew. Chem. Int. Ed. 59 (2020) 2565. doi: 10.1002/anie.201905645
115. [115]
  M.E. Hafez, H. Ma, W. Ma, et al., Angew. Chem. 131 (2019) 6393–6398. doi: 10.1002/ange.201901384
116. [116]
  W. Zhu, J. Zhang, Z. Jiang, et al., RSC Adv. 4 (2014) 17387–17392. doi: 10.1039/C3RA47593J
117. [117]
  G. Wu, V. Berka, P.J. Derry, et al., ACS Nano 13 (2019) 11203–11213. doi: 10.1021/acsnano.9b04229
118. [118]
  X. Ren, J. Liu, J. Ren, et al., Nanoscale 7 (2015) 19641–19646. doi: 10.1039/C5NR04685H
119. [119]
  S. Balou, P. Shandilya, A. Priye, Front. Chem. 10 (2022) 1023602. doi: 10.3389/fchem.2022.1023602
120. [120]
  S. Zhao, L. Yan, M. Cao, et al., ACS Appl. Mater. Interfaces 13 (2021) 53610–53617. doi: 10.1021/acsami.1c15926
121. [121]
  G. Qi, Y. Zhang, S. Xu, et al., Anal. Chem. 90 (2018) 13356–13364. doi: 10.1021/acs.analchem.8b03034
122. [122]
  J. Lu, K. Wang, W. Lei, et al., Mater. Sci. Eng. C 122 (2021) 111908. doi: 10.1016/j.msec.2021.111908
123. [123]
  M. Zhang, W. Wang, F. Wu, et al., Biomaterials 252 (2020) 120106. doi: 10.1016/j.biomaterials.2020.120106
124. [124]
  J. Li, J. Huang, Y. Ao, et al., ACS Appl. Mater. Interfaces 10 (2018) 22985–22996. doi: 10.1021/acsami.8b07090
125. [125]
  G. Murali, B. Kwon, H. Kang, et al., ACS Appl. Nano Mater. 5 (2022) 4376–4385. doi: 10.1021/acsanm.2c00443
126. [126]
  X. Li, X. Feng, C. Sun, et al., J. Control. Release 319 (2020) 104–118. doi: 10.1016/j.jconrel.2019.12.042
127. [127]
  C. Wang, P. Zhao, D. Jiang, et al., ACS Appl. Mater. Interfaces 12 (2020) 5624–5632. doi: 10.1021/acsami.9b21589
128. [128]
  S.Y. Li, H. Cheng, B.R. Xie, et al., ACS Nano 11 (2017) 7006–7018. doi: 10.1021/acsnano.7b02533
129. [129]
  C. Qian, J. Yu, Y. Chen, et al., Adv. Mater. 28 (2016) 3313–3320. doi: 10.1002/adma.201505869
130. [130]
  A. Sahu, K. Min, J. Jeon, et al., J. Control. Release 326 (2020) 442–454. doi: 10.1016/j.jconrel.2020.07.023
131. [131]
  K. Deng, C. Li, S. Huang, et al., Small 13 (2017) 1702299. doi: 10.1002/smll.201702299
132. [132]
  B. Gu, K.T. Yong, B. Liu, Small Methods 2 (2018) 1700392. doi: 10.1002/smtd.201700392
133. [133]
  A. Gulzar, J. Xu, D. Yang, et al., Dalton Trans. 47 (2018) 3931–3939. doi: 10.1039/c7dt04141a
134. [134]
  S. Feng, J. Lu, K. Wang, et al., Chem. Eng. J. 435 (2022) 134886. doi: 10.1016/j.cej.2022.134886
135. [135]
  J. Lu, Y. Mao, S. Feng, et al., Acta Biomater. 148 (2022) 310–322. doi: 10.1016/j.actbio.2022.06.001
136. [136]
  M.Z. Jin, W.L. Jin, Signal Transduct. Target Ther. 5 (2020) 166. doi: 10.1038/s41392-020-00280-x
137. [137]
  Z. Tang, Y. Liu, M. He, et al., Angew. Chem. Int. Ed. 58 (2019) 946–956. doi: 10.1002/anie.201805664
138. [138]
  D. Jana, Y. Zhao, Exploration 2 (2022) 20210238. doi: 10.1002/EXP.20210238
139. [139]
  L. Wang, M. Huo, Y. Chen, et al., Adv. Healthc. Mater. 7 (2018) e1701156. doi: 10.1002/adhm.201701156
140. [140]
  Y. Han, K. Ge, Y. Zhao, et al., Small 20 (2023) e2306656.
141. [141]
  T. Li, B. Cao, Y. Wang, et al., Aggregate 6 (2025) e70060. doi: 10.1002/agt2.70060
142. [142]
  Z. Su, H. Xu, Y. Zhang, et al., J. Mater. Chem. B 11 (2023) 4211–4226. doi: 10.1039/d3tb00384a
143. [143]
  S. Son, J.H. Kim, X. Wang, et al., Chem. Soc. Rev. 49 (2020) 3244–3261. doi: 10.1039/c9cs00648f
144. [144]
  Y. Chong, Q. Liu, C. Ge, Nano Today 37 (2021) 101076. doi: 10.1016/j.nantod.2021.101076
145. [145]
  Q. Huang, Z. Huang, C. Peng, et al., ACS Appl. Bio Mater. 6 (2023) 1906–1914. doi: 10.1021/acsabm.3c00127
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18. [18]
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19. [19]
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沈阳化工大学材料科学与工程学院沈阳 110142