Citation: Xinrui Xiao, Xingyu Chen, Ming Cao, Xiang Li, Congkui Tian, Hongen Cao, Lei Yu. Nano-Se pesticide synthesis from Se(Ⅳ) for industrial chain material balance[J]. Chinese Chemical Letters, ;2026, 37(12): 112507. doi: 10.1016/j.cclet.2026.112507 shu

Nano-Se pesticide synthesis from Se(Ⅳ) for industrial chain material balance

Xinrui Xiao ^a ,
Xingyu Chen ^a ,
Ming Cao ^a ,
Xiang Li ^a ,
Congkui Tian ^b ,
Hongen Cao ^{a, *,} ,
Lei Yu ^c

a.
School of Plant Protection, Yangzhou University, Yangzhou 225009, China
b.
Hubei Key Laboratory of Selenium Resource Research and Biological Application, Hubei Minzu University, Enshi 445000, China
c.
School of Chemistry and Materials, Yangzhou University, Yangzhou 225009, China

hecao@yzu.edu.cn

Received Date: 30 November 2025
Revised Date: 1 February 2026
Accepted Date: 5 February 2026
Available Online: 6 February 2026

Figures(8)

The disproportionation reaction of selenium powder with aqueous NaOH affords a facile route to Se(-Ⅱ), a key selenium species for synthesizing low-valence selenium carbohydrates, which are the compounds widely used in agriculture and medicine. However, Se(Ⅳ) is inevitably generated as a by-product, accounting for a 33% molar ratio of the reaction products. To address the material surplus of Se(Ⅳ) and achieve industrial chain material balance, this study converted Se(Ⅳ) into value-added nano-Se pesticide. The nano-Se showed uniform size, good stability, strong antioxidant activity, and favorable leaf wettability. It exhibited potent antifungal activity against Magnaporthe oryzae with a low EC₅₀ value of 15.21 mg/L and effective rice blast control in vivo, while enhancing rice antioxidant enzyme activities and showing high safety to non-target organisms. This work realizes Se(Ⅳ) recycling and provides a green rice blast control strategy.
- Selenium,
- Disproportionation reaction,
- Magnaporthe oryzae,
- Fertilizer,
- Pesticide
1. [1]
  M.P. Rayman, Lancet 379 (2012) 1256–1278. doi: 10.1016/S0140-6736(11)61452-9
2. [2]
  W. Ding, S. Wang, J. Gu, et al., Chin. Chem. Lett. 34 (2023) 108043. doi: 10.1016/j.cclet.2022.108043
3. [3]
  J. Gu, J. Gu, L. Yu, Chin. Chem. Lett. 36 (2025) 110727. doi: 10.1016/j.cclet.2024.110727
4. [4]
  J. Huang, Z. Wang, L. Sun, et al., Modern Agriculture 1 (2023) 34–42. doi: 10.1002/moda.2
5. [5]
  Y. Ma, F. Guo, H. Zhu, et al., Sci. Total Environ. 950 (2024) 175321. doi: 10.1016/j.scitotenv.2024.175321
6. [6]
  X. Zhang, H. He, J. Xiang, et al., J. Agric. Food Chem. 68 (2020) 15061–15073. doi: 10.1021/acs.jafc.0c05594
7. [7]
  H. Li, H. Liu, X. Tang, et al., Compr. Rev. Food Sci. F. 24 (2025) e70250. doi: 10.1111/1541-4337.70250
8. [8]
  Y. Ma, M. Liu, Y. Zhou, et al., Adv. Synth. Catal. 363 (2021) 5386–5406. doi: 10.1002/adsc.202101227
9. [9]
  W. Zhou, P. Li, J. Liu, et al., Ind. Eng. Chem. Res. 59 (2020) 10763–10767. doi: 10.1021/acs.iecr.0c01147
10. [10]
  Q. Wang, P. Li, T. Li, et al., Ind. Eng. Chem. Res. 60 (2021) 8659–8663. doi: 10.1021/acs.iecr.1c01437
11. [11]
  X. Li, H. Zhou, R. Qian, et al., Chin. Chem. Lett. 36 (2025) 110036. doi: 10.1016/j.cclet.2024.110036
12. [12]
  L. Xian, Q. Li, T. Li, et al., Chin. Chem. Lett. 34 (2023) 107878. doi: 10.1016/j.cclet.2022.107878
13. [13]
  X. Chen, S. Zhuang, W. Yan, et al., Chin. Chem. Lett. 35 (2024) 109635. doi: 10.1016/j.cclet.2024.109635
14. [14]
  X. Xiao, Z. Shao, L. Yu, Chin. Chem. Lett. 32 (2021) 2933–2938. doi: 10.1016/j.cclet.2021.03.047
15. [15]
  N. Cruz-Mireles, M. Osés-Ruiz, P. Derbyshire, et al., Cell 187 (2024) 2557–2573. doi: 10.1016/j.cell.2024.04.007
16. [16]
  H. Liu, X. Lu, M. Li, et al., Nat. Commun. 14 (2023) 5491. doi: 10.1038/s41467-023-41175-z
17. [17]
  L. Rani, K. Thapa, N. Kanojia, et al., J. Clean. Prod. 283 (2021) 124657. doi: 10.1016/j.jclepro.2020.124657
18. [18]
  Y. Tan, Q. Liang, Q. Hong, et al., Chem. Eng. J. 520 (2025) 165792. doi: 10.1016/j.cej.2025.165792
19. [19]
  W. Wang, M. Adeel Ghafar, L. Liuyang, et al., J. Agric. Food Chem. 73 (2025) 3353–3362. doi: 10.1021/acs.jafc.4c08172
20. [20]
  Q. Cheng, Y. Wang, C. Han, et al., J. Agric. Food Chem. 73 (2025) 11495–11514. doi: 10.1021/acs.jafc.5c01293
21. [21]
  Y. Ma, P. Yan, Z. Lv, et al., Adv. Funct. Mater. 35 (2025) 2509254. doi: 10.1002/adfm.202509254
22. [22]
  X. Zhang, J. Xiao, Y. Huang, et al., Nat. Commun. 16 (2025) 1721. doi: 10.1038/s41467-025-57028-w
23. [23]
  W. Li, L. Ma, Y. Ye, et al., Food Chem. 463 (2025) 141439. doi: 10.1016/j.foodchem.2024.141439
24. [24]
  Y. Li, R. Chang, L. Lu, et al., Food Chem. 482 (2025) 144212. doi: 10.1016/j.foodchem.2025.144212
25. [25]
  S. Jalali, M. Montazer, M. Rad, Carbohyd. Polym. 251 (2021) 117125. doi: 10.1016/j.carbpol.2020.117125
26. [26]
  H. Wang, Z. Li, X. Liang, et al., Food Chem. 402 (2025) 134470.
27. [27]
  C. Krishnaraj, S. Radhakrishnan, R. Ramachandran, et al., Chemosphere 301 (2022) 134790. doi: 10.1016/j.chemosphere.2022.134790
28. [28]
  Q. Liang, Q. Tian, Y. Tan, et al., J. Agric. Food Chem. 73 (2025) 24622–24633. doi: 10.1021/acs.jafc.5c08238
29. [29]
  N.A. Ahmed, E.M. Abdelrazek, H. Salaheldin, Int. J. Biol. Macromol. 283 (2024) 137765. doi: 10.1016/j.ijbiomac.2024.137765
30. [30]
  Z. Zhang, F. Kong, H. Ni, et al., Carbohyd. Polym. 144 (2016) 106–114. doi: 10.1016/j.carbpol.2016.02.030
31. [31]
  B.G. Tarladgis, A.W. Schoenmakers, Nature 210 (1966) 1151–1153. doi: 10.1038/2101151a0
32. [32]
  J. Yang, K. Liu, Y. Chen, et al., Nat. Commun. 16 (2025) 2627. doi: 10.1038/s41467-025-57839-x
33. [33]
  J. Tang, X. Tong, Y. Chen, et al., Nat. Commun. 14 (2023) 6401. doi: 10.1038/s41467-023-41878-3
34. [34]
  J. Yang, H. Ye, H. Xiang, et al., Adv. Funct. Mater. 33 (2023) 2303206. doi: 10.1002/adfm.202303206
35. [35]
  K. Mai, S. Yang, X. Zhao, et al., Chem. Eng. J. 479 (2024) 147357. doi: 10.1016/j.cej.2023.147357
36. [36]
  S. Wang, W. Wang, D. Xu, et al., Pest Manag. Sci. 81 (2025) 8064–8076. doi: 10.1002/ps.70114
37. [37]
  R. Yang, J. Yang, M. Liu, et al., Adv. Sci. 12 (2025) e04225. doi: 10.1002/advs.202504225
38. [38]
  L. Shi, W. Yan, L. Sun, et al., Pest Manag. Sci. 78 (2022) 4407–4416. doi: 10.1002/ps.7061
39. [39]
  J. Hu, C. Gong, Y. Jia, et al., ACS Appl. Mater. Interfaces 16 (2024) 60842–60855. doi: 10.1021/acsami.4c12611
40. [40]
  G. Li, Z. Gong, N. Dulal, et al., Nat. Commun. 14 (2023) 4146. doi: 10.1038/s41467-023-39880-w
41. [41]
  B. Liang, S. Lu, J. Hu, et al., ACS Appl. Mater. Interfaces 16 (2024) 15931–15945. doi: 10.1021/acsami.4c00324
42. [42]
  F. Ahmed, D. Zhang, X. Tang, et al., Foods 13 (2024) 4026. doi: 10.3390/foods13244026
43. [43]
  S. Huo, Y. Jiang, A. Gupta, et al., ACS Nano 10 (2016) 8732–8737. doi: 10.1021/acsnano.6b04207
44. [44]
  X. Chen, Y. Jiang, C. Wang, et al., ACS Nano 18 (2024) 13084–13097. doi: 10.1021/acsnano.4c01835
45. [45]
  H. Shang, C. Ma, C. Li, et al., ACS Nano 17 (2023) 13672–13684. doi: 10.1021/acsnano.3c02790
46. [46]
  Y. Huang, J. Tan, G. Wang, et al., ACS Appl. Nano Mater. 7 (2024) 12881–12890. doi: 10.1021/acsanm.4c01446
47. [47]
  J. Singh, S. Kumar, A. Alok, et al., J. Clean. Prod. 214 (2019) 1061–1070. doi: 10.1016/j.jclepro.2019.01.018
48. [48]
  L. Sun, C. Hou, N. Wei, et al., Chem. Eng. J. 478 (2023) 147294. doi: 10.1016/j.cej.2023.147294
49. [49]
  H. Jia, Y. Zhu, Q. Duan, et al., Control. Release 311 (2019) 301–318.
50. [50]
  W. Li, P. Zhang, H. Qiu, et al., Environ. Sci. Technol. 56 (2021) 1138–1148. doi: 10.3724/sp.j.1006.2021.03043
51. [51]
  M. Li, P. Zhang, Z. Guo, et al., ACS Nano 17 (2023) 14761–14774. doi: 10.1021/acsnano.3c02783
52. [52]
  S. Balusamy, S. Rahimi, J. Sukweenadhi, et al., Carbohyd. Polym. 284 (2022) 119189.
53. [53]
  G. Wang, H. Liu, Y. Zhou, et al., Pest Manag. Sci. 81 (2025) 5413–5427. doi: 10.1002/ps.8895
54. [54]
  X. Shen, Z. Yang, X. Dai, et al., Adv. Mater. 36 (2024) 2402745. doi: 10.1002/adma.202402745
55. [55]
  Y. Li, Y. Liu, D. Yang, et al., J. Hazard. Mater. 394 (2020) 122551. doi: 10.1016/j.jhazmat.2020.122551
56. [56]
  Z. Zhu, Y. Chen, G. Shi, et al., Food Chem. 219 (2017) 179–184. doi: 10.1016/j.foodchem.2016.09.138
57. [57]
  C. Zhou, D. Li, X. Shi, et al., J. Agric. Food Chem. 69 (2021) 14103–14114. doi: 10.1021/acs.jafc.1c05617
58. [58]
  R. Xing, X. Sun, Y. Wang, et al., Environ. Sci. Technol. 58 (2024) 19725–19735. doi: 10.1021/acs.est.4c07121
59. [59]
  H. Yu, S. Tang, H. Cheng, et al., ACS Nano 18 (2024) 32145–32161. doi: 10.1021/acsnano.4c11219
60. [60]
  Y. Jia, L. Chen, L. Kang, et al., ACS Nano 18 (2024) 20576–20590. doi: 10.1021/acsnano.4c05827
61. [61]
  Y. Wang, L. Feng, X. Sun, et al., ACS Nano 17 (2023) 15847–15856. doi: 10.1021/acsnano.3c03739
62. [62]
  C. Wang, B. Cheng, Z. Xiao, et al., Proc. Natl. Acad. Sci. U. S. A. 122 (2025) e2508456122. doi: 10.1073/pnas.2508456122
63. [63]
  H. Cao, X. Xiao, X. Zhang, L. Yu, Chin. Chem. Lett. 37 (2026) 112197. doi: 10.1016/j.cclet.2025.112197
1. [1]
  Hongen Cao , Xinrui Xiao , Xu Zhang , Lei Yu . The bio-applications of low-valence-selenium-substituted glucoses. Chinese Chemical Letters, 2026, 37(6): 112197-. doi: 10.1016/j.cclet.2025.112197
2. [2]
  Xingyu Chen , Sihui Zhuang , Weiyao Yan , Zhengli Zeng , Jianguo Feng , Hongen Cao , Lei Yu . Synthesis, antibacterial evaluation, and safety assessment of Se@PLA as a potent bactericide against Xanthomonas oryzae pv. oryzae. Chinese Chemical Letters, 2024, 35(10): 109635-. doi: 10.1016/j.cclet.2024.109635
3. [3]
  Jiajie Gu , Jiaxiang Gu , Lei Yu . Selenium and Alzheimer's disease. Chinese Chemical Letters, 2025, 36(8): 110727-. doi: 10.1016/j.cclet.2024.110727
4. [4]
  Kuanhong Cao , Sainan Chu , Yuanhua Ding , Shanming Lu , Lei Yu , Juan Du . Sustainable Se/C catalysts from carbohydrates: Unlocking oxidative deoximation reaction with high turnover numbers via free radical mechanisms. Chinese Chemical Letters, 2026, 37(1): 111486-. doi: 10.1016/j.cclet.2025.111486
5. [5]
  Yangxia Chen , Wei Liu , Yinghui Liu , Sirui Li , Hongfang Liu , Shuoshan Li , Luo Ying , Rongyi Chen , Tianfeng Chen . Synergistic convergence of selenium and nanotechnology in dermatological therapeutics: Mechanistic insights and clinical prospects. Chinese Chemical Letters, 2026, 37(3): 111298-. doi: 10.1016/j.cclet.2025.111298
6. [6]
  Jiahui Li , Qiao Shi , Ying Xue , Mingde Zheng , Long Liu , Tuoyu Geng , Daoqing Gong , Minmeng Zhao . The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers. Chinese Chemical Letters, 2024, 35(6): 109239-. doi: 10.1016/j.cclet.2023.109239
7. [7]
  Yanwei Duan , Qing Yang . Molecular targets and their application examples for interrupting chitin biosynthesis. Chinese Chemical Letters, 2025, 36(4): 109905-. doi: 10.1016/j.cclet.2024.109905
8. [8]
  Chao Chen , Wang Geng , Ke Li , Qiong Lei , Zhichao Jin , Xiuhai Gan . Pyridazine: A privileged scaffold in the development of 21^st-century pesticides. Chinese Chemical Letters, 2025, 36(8): 110902-. doi: 10.1016/j.cclet.2025.110902
9. [9]
  Xiaoxue Li , Hongwei Zhou , Rongrong Qian , Xu Zhang , Lei Yu . A concise synthesis of Se/Fe materials for catalytic oxidation reactions of anthracene and polyene. Chinese Chemical Letters, 2025, 36(3): 110036-. doi: 10.1016/j.cclet.2024.110036
10. [10]
  Yuxia Gao , Li Zhang , Chenhui Zhang , Fengpei Du . Chemical Empowerment for Green Development of Pesticides: From Molecular Design to Field Application. University Chemistry, 2025, 40(12): 78-86. doi: 10.12461/PKU.DXHX202509052
11. [11]
  Lu Huang , Jiang Wang , Hong Jiang , Lanfang Chen , Huanwen Chen . On-line determination of selenium compounds in tea infusion by extractive electrospray ionization mass spectrometry combined with a heating reaction device. Chinese Chemical Letters, 2025, 36(1): 109896-. doi: 10.1016/j.cclet.2024.109896
12. [12]
  Tingting Du , Siyu Lu , Dong Wang , Jian Zhang , Jixiang Chen . Recent advances of imidazole derivatives in pesticide chemistry. Chinese Chemical Letters, 2026, 37(7): 112280-. doi: 10.1016/j.cclet.2025.112280
13. [13]
  Fei Liu , Dong-Yang Zhao , Kai Sun , Ting-Ting Yu , Xin Wang . Comprehensive Experimental Design for Photochemical Synthesis, Analysis, and Characterization of Seleno-Containing Medium-Sized N-Heterocycles. University Chemistry, 2024, 39(3): 369-375. doi: 10.3866/PKU.DXHX202309047
14. [14]
  Ying Liu , Jia Ji , Yinling Hou , Lilan Guo , Xuan Lv . Selenium’s Journey. University Chemistry, 2025, 40(7): 218-224. doi: 10.12461/PKU.DXHX202409046
15. [15]
  Chu Wu , Zhichao Dong , Jinfang Hou , Jian Peng , Shuangyu Wu , Xiaofang Wang , Xiangwei Kong , Yue Jiang . Application of titanium-based advanced oxidation processes in pesticide-contaminated water purification: Emerging opportunities and challenges. Chinese Chemical Letters, 2025, 36(3): 110438-. doi: 10.1016/j.cclet.2024.110438
16. [16]
  Shuaige Bai , Shuai Huang , Ting Luo , Bin Feng , Yanpeng Fang , Feiyi Chu , Jie Dong , Wenbin Zeng . Debut of a responsive chemiluminescent probe for butyrylcholinesterase: Application in biological imaging and pesticide residue detection. Chinese Chemical Letters, 2025, 36(3): 110054-. doi: 10.1016/j.cclet.2024.110054
17. [17]
  Liangliang Cai , Xinyi Zhang , Jiayi Lu , Juan Xiang , Qiang Sun , Andrew T.S. Wee . Disorder–order transition of two-dimensional molecular networks by selenium doping. Chinese Chemical Letters, 2026, 37(5): 111874-. doi: 10.1016/j.cclet.2025.111874
18. [18]
  Fengzhang TU , Zhong JIN . Honeycomb-like N, O dual-doped carbon/selenium composites: Preparation and performance in alkali metal-selenium batteries. Chinese Journal of Inorganic Chemistry, 2025, 41(11): 2371-2384. doi: 10.11862/CJIC.20250227
19. [19]
  Zhi Li , Shuya Pan , Yuan Tian , Shaowei Liu , Weifeng Wei , Jinlin Wang , Tianfeng Chen , Ling Wang . Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer. Chinese Chemical Letters, 2024, 35(12): 110018-. doi: 10.1016/j.cclet.2024.110018
20. [20]
  Zhi-Peng Zhou , Xin Wei , Ming Yan , Zhi-Guo Wang , Rui Hong , Jia-Zhuang Xu . Multifunctional selenium nanoparticles/gelatin-based nanocomposite hydrogel adhesive for accelerated full-thickness wound healing. Chinese Chemical Letters, 2025, 36(9): 111400-. doi: 10.1016/j.cclet.2025.111400

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(13)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142