Citation: Lijun Chen, Biao Li, Dawei Wang, Guangfu Yang. Research progress of triketone compounds and their multifunctional biological activities[J]. Chinese Chemical Letters, ;2026, 37(8): 112484. doi: 10.1016/j.cclet.2026.112484 shu

Research progress of triketone compounds and their multifunctional biological activities

State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, Central China Normal University, Wuhan 430079, China

wangdw@ccnu.edu.cn

Received Date: 23 October 2025
Revised Date: 26 January 2026
Accepted Date: 30 January 2026
Available Online: 9 May 2026

Figures(6)

Triketones are fundamental building blocks in discovering many bioactive compounds due to their unique structural features. With three carbonyl groups and the ability to tautomerize into enol forms, triketones can form hydrogen bond donors and acceptors when binding to receptors and serve as metal chelation function groups. This structural diversity enables triketone compounds to be widely applied in herbicides, fungicides, insecticides, anticancer treatments, and tyrosine metabolism disorders, particularly applications as HPPD (4-hydroxyphenylpyruvate dioxygenase) inhibitors, where their herbicidal activity stems from the disruption of plant photosynthesis processes to effectively control weed growth. Moreover, in materials applications, their excellent reactivity allows for the post-polymerization modification of triketone-modified polymers. To facilitate the discovery of triketone pesticides and drugs, in this review, we summarize the current research progress of triketone compounds, highlighting their potential mechanisms of action and environmental fate.
- Triketone,
- HPPD inhibitors,
- Biological activity,
- Applications,
- Mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142