Citation: Yaling Wei, Jiaming He, Jinsong Ding, Caiyang Lu, Wenhu Zhou, Xinjie Deng. Zinc for skin diseases treatment: Progress and prospects in advanced delivery systems[J]. Chinese Chemical Letters, ;2026, 37(10): 112425. doi: 10.1016/j.cclet.2026.112425 shu

Zinc for skin diseases treatment: Progress and prospects in advanced delivery systems

Yaling Wei ^{a, 1} ,
Jiaming He ^{a, 1} ,
Jinsong Ding ^a ,
Caiyang Lu ^c ,
Wenhu Zhou ^{a, d, *,} ,
Xinjie Deng ^{b, *,}

a.
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
b.
Department of Dermatology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou 324000, China
c.
Hunan Center for Drug Evaluation and ADR Monitoring, Changsha 410013, China
d.
Hunan Key Laboratory of The Research and Development of Novel Pharmaceutical Preparations, School of Pharmaceutical Science, Changsha Medical University, Changsha 410219, China

zhouwenhuyaoji@163.com

qzxinjiedeng2025@wmu.edu.cn

Received Date: 9 October 2025
Revised Date: 14 January 2026
Accepted Date: 16 January 2026
Available Online: 16 January 2026

Figures(1)

Zinc plays a pivotal role in maintaining skin homeostasis, wound healing, and immune regulation, making it a promising therapeutic agent for diverse dermatological conditions. Despite its wide clinical application, conventional zinc formulations face significant limitations, including low bioavailability, systemic side effects, rapid ion release, and poor skin penetration. These shortcomings restrict their clinical efficacy and translation. Engineered carriers such as nanoparticles (NPs), hydrogels, and microneedles (MNs) offer opportunities to achieve controlled zinc release, enhance transdermal penetration, reduce local irritation, and enable combinational therapies with synergistic bioactivities. This review provides a comprehensive overview of zinc’s biological functions in skin physiology and pathology, critically discusses the bottlenecks of current zinc-containing medical materials, and highlights emerging delivery platforms designed to unlock its therapeutic potential. We further propose future research directions focusing on precision-targeted delivery, integration with advanced biomaterials, and exploration of zinc-based synergistic therapies.
- Zinc-containing biomaterials,
- Nanomedicine,
- Transdermal delivery,
- Skin penetration,
- Wound healing
1. [1]
  A.J. Alsaadi, F. Honarvar, M. Akrami, et al., Int. J. Pharm. 675 (2025) 125539. doi: 10.1016/j.ijpharm.2025.125539
2. [2]
  D. Furman, J. Auwerx, A.-L. Bulteau, et al., Nat. Aging 5 (2025) 1195–1206. doi: 10.1038/s43587-025-00901-6
3. [3]
  M. Rodrigues, N. Kosaric, C.A. Bonham, et al., Physiol. Rev. 99 (2019) 665–706. doi: 10.1152/physrev.00067.2017
4. [4]
  K. Kabashima, T. Honda, F. Ginhoux, et al., Nat. Rev. Immunol. 19 (2019) 19–30. doi: 10.1038/s41577-018-0084-5
5. [5]
  L.C. Biggs, C.S. Kim, Y.A. Miroshnikova, et al., J. Invest. Dermatol. 140 (2020) 284–290. doi: 10.1016/j.jid.2019.06.137
6. [6]
  A.K. D ˛ abrowska, F. Spano, S. Derler, et al., Skin Res. Technol. 24 (2018) 165–174. doi: 10.1111/srt.12424
7. [7]
  T. Quan, J. Dermatol. Sci. 112 (2023) 48–53. doi: 10.1016/j.jdermsci.2023.08.006
8. [8]
  L. Hao, Y. Zhang, Y. Sun, et al., Chin. Chem. Lett. 37 (2026) 111597. doi: 10.1016/j.cclet.2025.111597
9. [9]
  R.J. Hay, N.E. Johns, H.C. Williams, et al., J. Invest. Dermatol. 134 (2014) 1527–1534. doi: 10.1038/jid.2013.446
10. [10]
  C. Karimkhani, R.P. Dellavalle, L.E. Coffeng, et al., JAMA Dermatol. 153 (2017) 406–412. doi: 10.1001/jamadermatol.2016.5538
11. [11]
  Y. Dai, Q. Zhang, R. Gu, et al., Int. J. Pharm. 667 (2024) 124889. doi: 10.1016/j.ijpharm.2024.124889
12. [12]
  G. Langer, C.S. Wan, A. Fink, et al., Cochrane Database Syst. Rev. 2 (2024) CD003216.
13. [13]
  A. Podgórska, A. Kicman, S. Naliwajko, et al., Int. J. Mol. Sci. 25 (2024) 3823. doi: 10.3390/ijms25073823
14. [14]
  T. Searle, F.R. Ali, F. Al-Niaimi, J. Dermatol. Treat. 33 (2022) 2455–2458. doi: 10.1080/09546634.2022.2062282
15. [15]
  P. Zou, Y. Du, C. Yang, et al., Front. Med. 9 (2022) 1093868.
16. [16]
  N.A. Gray, A. Dhana, D.j. Stein, et al., J. Eur. Acad. Dermatol. Venereol. 33 (2019) 1042–1050. doi: 10.1111/jdv.15524
17. [17]
  J.E. Kim, S.R. Yoo, M.G. Jeong, et al., Acta Derm. Venereol. 94 (2014) 558–562. doi: 10.2340/00015555-1772
18. [18]
  C. Wiegand, U.C. Hipler, S. Boldt, et al., Clin. Cosmet. Investig. Dermatol. 6 (2013) 115–121.
19. [19]
  Z. Zhang, W. Li, D. Chang, et al., Bioact. Mater. 24 (2023) 81–95.
20. [20]
  H. Ruan, Y. Zhong, H. Ding, et al., Chem. Eng. J. 499 (2024) 155961. doi: 10.1016/j.cej.2024.155961
21. [21]
  A. Prasad, Am. J. Clin. Nutr. 53 (1991) 403–412. doi: 10.1093/ajcn/53.2.403
22. [22]
  P.M. Barnes, E.J. Moynahan, Proc. R. Soc. Med. 66 (1973) 327–329. doi: 10.1177/003591577306600411
23. [23]
  J.C. Fitzherbert, Med. J. Aust. 2 (1977) 685–686. doi: 10.5694/j.1326-5377.1977.tb99210.x
24. [24]
  D. Xiao, Y. Huang, Z. Fang, et al., Mater. Today Bio 34 (2025) 102221. doi: 10.1016/j.mtbio.2025.102221
25. [25]
  C. Stanescu, I. Chiscop, D. Mihalache, et al., Molecules 30 (2025) 3568. doi: 10.3390/molecules30173568
26. [26]
  G. Michaelsson, K. Ljunghall, B.G. Danielson, Acta Derm. Venereol. 60 (1980) 295–299. doi: 10.2340/0001555560295299
27. [27]
  E. Rallis, K. Lotsaris, V.S. Grech, et al., Nutrients 16 (2024) 4354. doi: 10.3390/nu16244354
28. [28]
  M.I. Costa, A.B. Sarmento-Ribeiro, A.C. Gonçalves, Int. J. Mol. Sci. 24 (2023) 4822. doi: 10.3390/ijms24054822
29. [29]
  W. Maret, Adv. Nutr. 4 (2013) 82–91. doi: 10.3945/an.112.003038
30. [30]
  L. Foster, J.A. Foppiani, H. Xun, et al., Curr. Issues. Mol. Biol. 46 (2024) 12088–12098. doi: 10.3390/cimb46110717
31. [31]
  Z. Al-Khafaji, S. Brito, B.H. Bin, Int. J. Mol. Sci. 23 (2022) 16165. doi: 10.3390/ijms232416165
32. [32]
  X. Nqoro, R. Taziwa, Pharmaceutics 16 (2024) 155. doi: 10.3390/pharmaceutics16020155
33. [33]
  J. Yang, H. Yang, A. Xu, et al., Front. Public Health 8 (2020) 450. doi: 10.3389/fpubh.2020.00450
34. [34]
  Ö. Kutlu, A.S. Karadağ, U. Wollina, An. Bras. Dermatol. 98 (2023) 75–83. doi: 10.1016/j.abd.2022.01.006
35. [35]
  A. Ip, I. Muller, A.W.A. Geraghty, et al., Br. J. Dermatol. 183 (2020) 349–356. doi: 10.1111/bjd.18684
36. [36]
  A.M. Layton, J. Ravenscroft, Lancet Child Adolesc. Health 7 (2023) 136–144. doi: 10.1016/S2352-4642(22)00314-5
37. [37]
  R.V. Reynolds, H. Yeung, C.E. Cheng, et al., J. Am. Acad. Dermatol. 90 (2024) 1006.e1–1006.e30. doi: 10.1016/j.jaad.2023.12.017
38. [38]
  M. Kahsay, B. Assefa, F. Daba, et al., Medico Res. Chron. 4 (2017) 481–494.
39. [39]
  S.M. Awad, H. Morsy, A.A. Sayed, et al., J. Cosmet. Dermatol. 17 (2018) 203–208. doi: 10.1111/jocd.12366
40. [40]
  B. Mahor, B. Bhimte, H. Nasrat, et al., Int. J. Sci. Res. 03 (2023) 55–56.
41. [41]
  B.E. Yee, P. Richards, J.Y. Sui, et al., Dermatol. Ther. 33 (2020) e14252.
42. [42]
  C. Otami, N. Chandra, I.B.S. Sitohang, J. Gen. Proced. Dermatol. Venereol. 4 (2020) 52–57. doi: 10.19100/jdvi.v4i2.167
43. [43]
  Y.S. Bae, N.D. Hill, Y. Bibi, et al., Dermatol. Clin. 28 (2010) 587–597. doi: 10.1016/j.det.2010.03.006
44. [44]
  J. Cervantes, A.E. Eber, M. Perper, et al., Dermatol. Ther. 31 (2018) 12576. doi: 10.1111/dth.12576
45. [45]
  K.E. Sharquie, A.A. Noaimi, S.A. Al-Hashimy, et al., J. Cosmet. Dermatol. Sci. Appl. 4 (2014) 60–65. doi: 10.4236/jcdsa.2014.41009
46. [46]
  M.S. Sayyafan, M. Ramzi, R. Salmanpour, J. Dermatol. Treat. 31 (2020) 730–733. doi: 10.1080/09546634.2019.1606394
47. [47]
  I.B.S. Sitohang, Y.F. Yahya, R. Simanungkalit, et al., J. Clin. Aesthetic Dermatol. 13 (2020) 27–31.
48. [48]
  D. Crainic, R. Popescu, C.D. Vlad, et al., Biomedicines 13 (2025) 2156. doi: 10.3390/biomedicines13092156
49. [49]
  C.H. Huang, Y. Fu, C.C. Chi, JAMA Dermatol. 157 (2021) 963–970. doi: 10.1001/jamadermatol.2021.2196
50. [50]
  G. Yang, G. Chen, Z. Gu, Mol. Pharm. 18 (2021) 483–490. doi: 10.1021/acs.molpharmaceut.0c00041
51. [51]
  W.R. Heymann, J. Am. Acad. Dermatol. 86 (2022) 301–302. doi: 10.1016/j.jaad.2021.11.013
52. [52]
  T. Dainichi, M. Iwata, Y. Kaku, J. Dermatol. Sci. 112 (2023) 120–127. doi: 10.1016/j.jdermsci.2023.09.008
53. [53]
  I.N. Kondrakhina, D.A. Verbenko, A.M. Zatevalov, et al., Diagnostics 10 (2020) 336. doi: 10.3390/diagnostics10050336
54. [54]
  J. Lalosevic, M. Gajic-Veljic, J.L. Misovic, et al., Acta Derm. Venereol. 103 (2023) 13358. doi: 10.2340/actadv.v103.13358
55. [55]
  N.S.A. Abdel Fattah, M.M. Atef, S.M.Q. Al-Qaradaghi, Int. J. Dermatol. 55 (2016) 24–29. doi: 10.1111/ijd.12769
56. [56]
  R.D. Ead, Br. J. Dermatol. 104 (1981) 483–484. doi: 10.1111/j.1365-2133.1981.tb15323.x
57. [57]
  R.S. Berger, J.L. Fu, K.A. Smiles, et al., Br. J. Dermatol. 149 (2003) 354–362. doi: 10.1046/j.1365-2133.2003.05435.x
58. [58]
  M. Jarosz, M. Olbert, G. Wyszogrodzka, et al., Inflammopharmacology 25 (2017) 11–24. doi: 10.1007/s10787-017-0309-4
59. [59]
  S.M. Langan, A.D. Irvine, S. Weidinger, Lancet Lond. Engl. 396 (2020) 345–360. doi: 10.1016/S0140-6736(20)31286-1
60. [60]
  C. Roduit, R. Frei, M. Depner, et al., JAMA Pediatr. 171 (2017) 655–662. doi: 10.1001/jamapediatrics.2017.0556
61. [61]
  Z.C. Chiesa Fuxench, J.K. Block, M. Boguniewicz, et al., J. Invest. Dermatol. 139 (2019) 583–590. doi: 10.1016/j.jid.2018.08.028
62. [62]
  K. Piontek, T. Ittermann, A. Arnold, et al., Allergy 77 (2022) 1915–1917. doi: 10.1111/all.15288
63. [63]
  M. Toyran, M. Kaymak, E. Vezir, et al., J. Investig. Allergol. Clin. Immunol. 22 (2012) 341–344.
64. [64]
  K.L.E. Hon, S.S. Wang, E.C.W. Hung, et al., Pediatr. Allergy Immunol. 21 (2010) 831–836. doi: 10.1111/j.1399-3038.2010.01022.x
65. [65]
  D.O.D. Abdallah, R.K. Farhan, D.W.S. Najim, Int. J. Dermatol. Sci. 6 (2024) 30–35. doi: 10.33545/26649772.2024.v6.i1a.33
66. [66]
  O. Atay, S. Asilsoy, S. Sirin, et al., Asthma Allergy Immunol. 21 (2023) 89–94. doi: 10.21911/aai.147
67. [67]
  Y. Wei, X. Zhu, S. Lin, et al., Biomed. Pharmacother. 177 (2024) 117129. doi: 10.1016/j.biopha.2024.117129
68. [68]
  F.J. Bath-Hextall, C. Jenkinson, R. Humphreys, et al., Cochrane Database Syst. Rev. 2012 (2012) CD005205.
69. [69]
  Y. Zhang, S. Dong, Y. Ma, et al., Front. Endocrinol. 15 (2024) 1308822. doi: 10.3389/fendo.2024.1308822
70. [70]
  A.W. Armstrong, A. Blauvelt, K.C. Duffin, et al., Nat. Rev. Dis. Primer 11 (2025) 45. doi: 10.1038/s41572-025-00630-5
71. [71]
  A.W. Armstrong, C. Read, JAMA 323 (2020) 1945–1960. doi: 10.1001/jama.2020.4006
72. [72]
  X. Chen, W. Chen, W. Zhu, et al., J. Eur. Acad. Dermatol. Venereol. 30 (2016) 53–54.
73. [73]
  V.M. Rao, M. Deepthi, K. Ramalingam, et al., IP Indian J. Clin. Exp. Dermatol. 5 (2025) 239–242.
74. [74]
  G. Sadeghian, H. Ziaei, M.A. Nilforoushzadeh, Acta Dermatovenerol. Alp. Pannonica Adriat. 20 (2011) 187–190.
75. [75]
  L. Martinengo, M. Olsson, R. Bajpai, et al., Ann. Epidemiol. 29 (2019) 8–15. doi: 10.1016/j.annepidem.2018.10.005
76. [76]
  E. Eriksson, P.Y. Liu, G.S. Schultz, et al., Wound Repair. Regen. 30 (2022) 156–171. doi: 10.1111/wrr.12994
77. [77]
  C.K. Sen, Adv. Wound Care 10 (2021) 281–292. doi: 10.1089/wound.2021.0026
78. [78]
  P. Lin, M. Sermersheim, H. Li, et al., Nutrients 10 (2018) 16.
79. [79]
  N. Mutlu, L. Liverani, F. Kurtuldu, et al., Int. J. Biol. Macromol. 213 (2022) 845–857. doi: 10.1016/j.ijbiomac.2022.05.199
80. [80]
  J.F. Sánchez-Cruz, P. Aguilar-Alonso, H.A. Rubio-Zapata, et al., Cir. Cir. 90 (2022) 34–40.
81. [81]
  M. Momen-Heravi, E. Barahimi, R. Razzaghi, et al., Wound Repair. Regen. 25 (2017) 512–520. doi: 10.1111/wrr.12537
82. [82]
  E. Cereda, A. Gini, C. Pedrolli, et al., J. Am. Geriatr. Soc. 57 (2009) 1395–1402. doi: 10.1111/j.1532-5415.2009.02351.x
83. [83]
  H.E. Strömberg, M.S. Agren, Br. J. Dermatol. 111 (1984) 461–468. doi: 10.1111/j.1365-2133.1984.tb06610.x
84. [84]
  O. Isard, A.C. Knol, M.F. Ariès, et al., J. Invest. Dermatol. 131 (2011) 59–66. doi: 10.1038/jid.2010.281
85. [85]
  Y. Xiang, J. Lu, C. Mao, et al., Sci. Adv. 9 (2023) eadf0854. doi: 10.1126/sciadv.adf0854
86. [86]
  T. Wen, Z. Lin, Y. Zhao, et al., ACS Appl. Mater. Interfaces 13 (2021) 48433–48448. doi: 10.1021/acsami.1c15673
87. [87]
  M. Rihova, S. Azpeitia, K. Cihalova, et al., J. Control. Release 383 (2025) 113777. doi: 10.1016/j.jconrel.2025.113777
88. [88]
  A. Sirelkhatim, S. Mahmud, A. Seeni, et al., Nano-Micro Lett. 7 (2015) 219–242. doi: 10.1007/s40820-015-0040-x
89. [89]
  J. Liu, Y. Kang, S. Yin, et al., Small 15 (2019) 1901073. doi: 10.1002/smll.201901073
90. [90]
  F. Zhang, T. Wang, W. Wang, et al., J. Nanobiotechnology 23 (2025) 404. doi: 10.1186/s12951-025-03414-x
91. [91]
  J. Zhu, T. Wen, Y. Ma, et al., J. Control. Release 382 (2025) 113754. doi: 10.1016/j.jconrel.2025.113754
92. [92]
  E.R. Gatiatulina, E.A. Sheina, O.N. Nemereshina, et al., Biol. Trace Elem. Res. 197 (2020) 202–212. doi: 10.1007/s12011-019-01985-z
93. [93]
  Y. Chen, Q. Zhu, Y. Zhou, et al., Mater. Today Bio 34 (2025) 102145. doi: 10.1016/j.mtbio.2025.102145
94. [94]
  B.K. Handjiski, S. Eichmüller, U. Hofmann, et al., Br. J. Dermatol. 131 (1994) 303–310. doi: 10.1111/j.1365-2133.1994.tb08515.x
95. [95]
  J. Olechnowicz, A. Tinkov, A. Skalny, et al., J. Physiol. Sci. JPS 68 (2018) 19–31. doi: 10.1007/s12576-017-0571-7
96. [96]
  F.M. Tsai, L.K. Wang, M.L. Chen, et al., Indian J. Pharm. Sci. 81 (2019) 781–785.
97. [97]
  Y. Yang, P. Wang, Y. Gong, et al., Theranostics 13 (2023) 3675–3688. doi: 10.7150/thno.84118
98. [98]
  C.H. Pratt, L.E. King, A.G. Messenger, et al., Nat. Rev. Dis. Primer 3 (2017) 17011. doi: 10.1038/nrdp.2017.11
99. [99]
  A. Alkhalifah, A. Alsantali, E. Wang, et al., J. Am. Acad. Dermatol. 62 (2010) 177–188. doi: 10.1016/j.jaad.2009.10.032
100. [100]
  R. Kurmis, J. Greenwood, E. Aromataris, J. Burn. Care Res. 37 (2016) 143–159. doi: 10.1097/BCR.0000000000000259
101. [101]
  J. Lou, H. Duan, Q. Qin, et al., Pharmaceutics 15 (2023) 484. doi: 10.3390/pharmaceutics15020484
102. [102]
  M.K. Marschütz, A. Bernkop-Schnürch, Biomaterials 21 (2000) 1499–1507. doi: 10.1016/S0142-9612(00)00039-9
103. [103]
  D. Ramadon, M.T.C. McCrudden, A.J. Courtenay, et al., Drug Deliv. Transl. Res. 12 (2022) 758–791. doi: 10.1007/s13346-021-00909-6
104. [104]
  W.Y. Jeong, M. Kwon, H.E. Choi, et al., Biomater. Res. 25 (2021) 24. doi: 10.1186/s40824-021-00226-6
105. [105]
  F. Sabbagh, B.S. Kim, J. Control. Release 341 (2022) 132–146. doi: 10.1016/j.jconrel.2021.11.025
106. [106]
  C. Lu, C. Chang, Y. Zheng, et al., ACS Appl. Mater. Interfaces 16 (2024) 60027–60044. doi: 10.1021/acsami.4c15042
107. [107]
  H. Yagai, Y. Horio, K. Wakimoto, et al., J. Funct. Foods. 116 (2024) 106176. doi: 10.1016/j.jff.2024.106176
108. [108]
  Y. Gao, L. Wang, C. Zhou, et al., Chin. Chem. Lett. 36 (2025) 110028. doi: 10.1016/j.cclet.2024.110028
109. [109]
  V. Deekala, B. Babu, R. Rudraraju, Indian J. Biochem. Biophys. 56 (2019) 500–505.
110. [110]
  R. Brayner, R. Ferrari-Iliou, N. Brivois, et al., Nano Lett. 6 (2006) 866–870. doi: 10.1021/nl052326h
111. [111]
  A. Joe, S.H. Park, K.D. Shim, et al., J. Ind. Eng. Chem. 45 (2017) 430–439. doi: 10.1016/j.jiec.2016.10.013
112. [112]
  Y. Jiang, L. Zhang, D. Wen, et al., Mater. Sci. Eng. C 69 (2016) 1361–1366. doi: 10.1016/j.msec.2016.08.044
113. [113]
  L. Valenzuela, A. Iglesias, M. Faraldos, et al., J. Hazard. Mater. 369 (2019) 665–673. doi: 10.1016/j.jhazmat.2019.02.073
114. [114]
  J. Zhu, T. Wen, Y. Ma, et al., Adv. Healthc. Mater. 14 (2025) 2501009. doi: 10.1002/adhm.202501009
115. [115]
  H. Zheng, Y. Zhang, L. Liu, et al., J. Am. Chem. Soc. 138 (2016) 962–968. doi: 10.1021/jacs.5b11720
116. [116]
  S. Yao, J. Chi, Y. Wang, et al., Adv. Healthc. Mater. 10 (2021) 2100056. doi: 10.1002/adhm.202100056
117. [117]
  Z. He, Y. Liu, H. Wang, et al., ACS Appl. Mater. Interfaces 14 (2022) 39172–39187. doi: 10.1021/acsami.2c07732
118. [118]
  Z. Wei, M. Robertson, J. Qian, et al., ACS Appl. Mater. Interfaces 17 (2025) 6103–6115. doi: 10.1021/acsami.4c20399
119. [119]
  S. Hasanzadeh, M.I. Read, A.R. Bland, et al., Pharmacol. Res. 159 (2020) 104921. doi: 10.1016/j.phrs.2020.104921
120. [120]
  Y.S. Fu, T.H. Chen, L. Weng, et al., Biomed. Pharmacother. 141 (2021) 111888. doi: 10.1016/j.biopha.2021.111888
121. [121]
  Y. Wang, T. Ying, J. Li, et al., Chem. Eng. J. 402 (2020) 126273. doi: 10.1016/j.cej.2020.126273
122. [122]
  S. Zhang, X. Zhao, W. Zhang, et al., Bioact. Mater. 49 (2025) 63–84.
123. [123]
  M.A. Shalaby, M.M. Anwar, H. Saeed, J. Polym. Res. 29 (2022) 91. doi: 10.1007/s10965-021-02870-x
124. [124]
  D. Chenthamara, S. Subramaniam, S.G. Ramakrishnan, et al., Biomater. Res. 23 (2019) 20. doi: 10.1186/s40824-019-0166-x
125. [125]
  X. Cui, J. Li, Y. Hartanto, et al., Adv. Healthc. Mater. 9 (2020) 1901648. doi: 10.1002/adhm.201901648
126. [126]
  X. Liang, C. Huang, H. Liu, et al., Chin. Chem. Lett. 35 (2024) 109442. doi: 10.1016/j.cclet.2023.109442
127. [127]
  Y. Feng, Z. Zhang, W. Tang, et al., Exploration 3 (2023) 20220173. doi: 10.1002/EXP.20220173
128. [128]
  L. Tan, M. Li, H. Chen, et al., Nano Today 52 (2023) 101962. doi: 10.1016/j.nantod.2023.101962
129. [129]
  Z. Liang, J. Luo, S. Liu, et al., Chem. Eng. J. 475 (2023) 146092. doi: 10.1016/j.cej.2023.146092
130. [130]
  R. Jamaledin, C.K.Y. Yiu, E.N. Zare, et al., Adv. Mater. 32 (2020) 2002129. doi: 10.1002/adma.202002129
131. [131]
  Y. Chen, J. Zhu, J. Ding, et al., Chin. Chem. Lett. 35 (2024) 108706. doi: 10.1016/j.cclet.2023.108706
132. [132]
  T. Peng, Y. Chen, X. Luan, et al., Bioact. Mater. 45 (2025) 274–300.
133. [133]
  T. Liu, J. Fu, Z. Zheng, et al., Theranostics 15 (2025) 3424–3438. doi: 10.7150/thno.103080
134. [134]
  J. Yu, J. Wang, Y. Zhang, et al., Nat. Biomed. Eng. 4 (2020) 499–506. doi: 10.1038/s41551-019-0508-y
135. [135]
  Y. Sun, J. Liu, H. Wang, et al., Adv. Funct. Mater. 31 (2021) 2100218. doi: 10.1002/adfm.202100218
136. [136]
  X. Zhang, Y. Wang, J. Chi, et al., Research 2020 (2020) 7462915.
137. [137]
  S.C.S. Hu, C.C.E. Lan, J. Dermatol. Sci. 84 (2016) 121–127. doi: 10.1016/j.jdermsci.2016.07.008
138. [138]
  J. Yang, W. Zeng, P. Xu, et al., Acta Biomater. 140 (2022) 206–218. doi: 10.1016/j.actbio.2021.11.043
139. [139]
  J. Dong, W. Zhou, X. Hu, et al., Biomaterials 307 (2024) 122515. doi: 10.1016/j.biomaterials.2024.122515
140. [140]
  Z. Deng, Y. Guo, X. Wang, et al., Theranostics 15 (2025) 1439–1455. doi: 10.7150/thno.102569
141. [141]
  K. Qin, Y. Gui, Y. Li, et al., ACS Appl. Mater. Interfaces 15 (2023) 6338–6353. doi: 10.1021/acsami.2c17328
142. [142]
  H. Gong, G. Sun, W. Shi, et al., Carbon Energy 6 (2024) e432. doi: 10.1002/cey2.432
143. [143]
  F. Meng, C. Qu, L. Wang, et al., J. Colloid. Interface Sci. 684 (2025) 492–502. doi: 10.1016/j.jcis.2025.01.010
144. [144]
  J. Lin, L. Dong, Y.M. Liu, et al., Natl. Sci. Rev. 10 (2023) nwad179. doi: 10.1093/nsr/nwad179
145. [145]
  Y. Xue, L. Zhang, J. Chen, et al., Biomaterials 321 (2025) 123293. doi: 10.1016/j.biomaterials.2025.123293
146. [146]
  S. Lee, G. Lee, M. Oh, Acc. Chem. Res. 57 (2024) 3113–3125. doi: 10.1021/acs.accounts.4c00469
147. [147]
  J. Li, Y. Xin, Z. Dong, et al., Chem. Eng. J. 500 (2024) 156655. doi: 10.1016/j.cej.2024.156655
148. [148]
  T. Liu, B. Xiao, F. Xiang, et al., Nat. Commun. 11 (2020) 2788. doi: 10.1038/s41467-020-16544-7
149. [149]
  X. Ren, Y. Hu, L. Chang, et al., Regen. Biomater. 9 (2022) rbac012. doi: 10.1093/rb/rbac012
150. [150]
  L. Qiu, C. Ouyang, W. Zhang, et al., J. Nanobiotechnology 21 (2023) 163. doi: 10.1186/s12951-023-01924-0
151. [151]
  J. Xu, H. Chen, H. Qian, et al., J. Nanobiotechnology 20 (2022) 448. doi: 10.1186/s12951-022-01651-y
152. [152]
  X. Zhai, H. Hu, M. Hu, et al., Carbohydr. Polym. 334 (2024) 122064. doi: 10.1016/j.carbpol.2024.122064
153. [153]
  S. Dai, L. Yao, L. Liu, et al., Acta Biomater. 186 (2024) 454–469. doi: 10.1016/j.actbio.2024.07.045
154. [154]
  R. Wang, X. Li, C. Wang, et al., Biomaterials 318 (2025) 123160. doi: 10.1016/j.biomaterials.2025.123160
155. [155]
  X. Yang, S. Wang, H. Liu, et al., J. Adv. Res. 78 (2025) 47–62. doi: 10.1016/j.jare.2025.02.005
156. [156]
  S. Wang, X. Yang, S. Cheng, et al., Food Biosci. 58 (2024) 103722. doi: 10.1016/j.fbio.2024.103722
157. [157]
  Y. Yu, G. Jin, Y. Xue, et al., Acta Biomater. 49 (2017) 590–603. doi: 10.1016/j.actbio.2016.11.067
158. [158]
  H. Hillaireau, P. Couvreur, Cell. Mol. Life Sci. 66 (2009) 2873–2896. doi: 10.1007/s00018-009-0053-z
159. [159]
  B. Cheng, J. Zhou, X. Wang, et al., Chem. Eng. J. 494 (2024) 153071. doi: 10.1016/j.cej.2024.153071
160. [160]
  T. Kambe, T. Tsuji, A. Hashimoto, et al., Physiol. Rev. 95 (2015) 749–784. doi: 10.1152/physrev.00035.2014
161. [161]
  S.R. Hennigar, A.M. Kelley, J.P. McClung, Adv. Nutr. 7 (2016) 735–746. doi: 10.3945/an.116.012518
162. [162]
  F. Yang, Y. Xue, F. Wang, et al., Bioact. Mater. 26 (2023) 88–101.
163. [163]
  X. Lai, M. Wang, Y. Zhu, et al., J. Hazard. Mater. 410 (2021) 124566. doi: 10.1016/j.jhazmat.2020.124566
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沈阳化工大学材料科学与工程学院沈阳 110142