Citation: Haibo Mei, Anas Semghouli, Loránd Kiss, Jianlin Han. Recent advances on cyclization reaction of indole-tethered alkenes for the construction of polyheterocycles[J]. Chinese Chemical Letters, ;2026, 37(8): 112405. doi: 10.1016/j.cclet.2026.112405 shu

Recent advances on cyclization reaction of indole-tethered alkenes for the construction of polyheterocycles

Haibo Mei ^a ,
Anas Semghouli ^b ,
Loránd Kiss ^{b, *,} ,
Jianlin Han ^{a, *,}

a.
Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, China
b.
Institute of Organic Chemistry, Stereochemistry Research Group, HUN-REN Research Centre for Natural Sciences, H-1117 Budapest, Magyar tudósok krt. 2, Hungary

kiss.lorand@ttk.hu

hanjl@njfu.edu.cn

Received Date: 27 October 2025
Revised Date: 29 December 2025
Accepted Date: 12 January 2026
Available Online: 12 January 2026

Figures(48)

Indole-containing polyheterocycles belong to an extremely important class of organic compounds, and the related skeletons are found in many natural products and bioactive molecules. They play an important role in synthetic and medicinal chemistry, agrochemicals, and advanced materials. Moreover, they also serve as versatile building blocks and tools for constructing more complex molecules. Thus, development of efficient methods for assembly of indole-containing polyheterocycles has attracted considerable attention in recent years. The aim of this review is to summarize recent developments in the synthesis of indole-fused or spired polycyclic compounds via cyclization of indole-tethered alkenes. Indole-tethered alkenes with alkenyl species linked to different position of indole moiety is presented.
- Indole-tethered alkenes,
- Cyclization reaction,
- Fused polycyclic compounds,
- Polycyclic indoles,
- Synthetic methods,
- Bioactive molecules
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沈阳化工大学材料科学与工程学院沈阳 110142