Citation: Chaojia Luo, Hongxia Wang, Jie Yu, Yan Zhao, Yong Chen. Supramolecular xanthium-like nanoreactor integrating photothermal effect, fenton reaction, and chemotherapy for targeted antitumor[J]. Chinese Chemical Letters, ;2026, 37(10): 112403. doi: 10.1016/j.cclet.2026.112403 shu

Supramolecular xanthium-like nanoreactor integrating photothermal effect, fenton reaction, and chemotherapy for targeted antitumor

Chaojia Luo ^{a, 1} ,
Hongxia Wang ^{a, 1} ,
Jie Yu ^{a, *,} ,
Yan Zhao ^{a, *,} ,
Yong Chen ^{b, *,}

a.
College of Chemistry and Chemical Engineering, Yunnan Key Laboratory of Modern Separation Analysis and Substance Transformation, Yunnan Normal University, Kunming 650500, China
b.
College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

yujie5977@126.com

zhaooyann@163.com

yongchen@nankai.edu.cn

Received Date: 30 August 2025
Revised Date: 30 December 2025
Accepted Date: 12 January 2026
Available Online: 12 January 2026

Figures(5)

Herein, we report a xanthium-like multicomponent supramolecular assembly with target and effective anticancer ability, which integrates photothermal therapy (PTT), chemodynamic therapy (CDT), and chemotherapy. The ferrocene-modified iron-based metal-organic frameworks (Fc-MIL-88B) act as the core-carrier to effectively doped photothermal reagent gold nanoparticles (Au) and encapsulate the model drug emodin, then further bind with the biotin-modified cyclodextrin (Bio-PE-CD) as the targeting "thorns" for cancer cells, ultimately forming the nanoreactor Fc-MIL-88B@Au@emodin@Bio-PE-CD. Notably, the supramolecular reactor not only exhibits tumor microenvironment-responsive disassembly performance to release anticancer drugs but also provides an abundant Fe source for intracellular Fenton reaction to produce hydroxyl radicals, then cooperating with the photothermal effect of gold nanoparticles to induce apoptosis of cancer cells. Finally, the trinity supramolecule exhibits excellent therapeutic efficacy and biosafety at the cellular and in vivo levels, providing a novel strategy for the development of synergistic antitumor nanoplatforms.
- Cyclodextrin,
- Supramolecular assembly,
- Nanoreactor,
- Metal-organic frameworks,
- Synergistic anticancer
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沈阳化工大学材料科学与工程学院沈阳 110142