Citation: Yufen Lv, Lianhui Song, Huilan Yue, Zuli Wang, Wei Wei. Photocatalytic multi-component carbonthioesterification reactions to construct quinoxalin-2(1H)-one-containing thioesters and their antitumor activities against HepG2[J]. Chinese Chemical Letters, ;2026, 37(12): 112309. doi: 10.1016/j.cclet.2025.112309 shu

Photocatalytic multi-component carbonthioesterification reactions to construct quinoxalin-2(1H)-one-containing thioesters and their antitumor activities against HepG2

Yufen Lv ^a ,
Lianhui Song ^a ,
Huilan Yue ^b ,
Zuli Wang ^d ,
Wei Wei ^{a, c, *,}

a.
School of Chemistry and Chemical Engineering, Qinghai Normal University, Xining 810008, China
b.
Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China
c.
School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, China
d.
National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass, Nanjing Forestry University, Nanjing 210037, China

weiweiqfnu@163.com

Received Date: 25 September 2025
Revised Date: 8 December 2025
Accepted Date: 21 December 2025
Available Online: 23 December 2025

Figures(7)

Visible-light induced multi-component carbonthioesterification reaction of alkenes with quinoxalin-2(1H)-ones, elemental sulfur and α-ketoacids has been developed. The present transformation is conducted under mild conditions to afford a wide range of biologically important quinoxalin-2(1H)-one-containing thioesters in moderate to good yields. Interestingly, the formed products show the potency of antitumor activities against HepG2. A mechanistic investigation indicates that carbonyl thiyl radical is formed through the coupling of photocatalytic activated elemental sulphur with acyl radical derived from decarboxylation of α-ketoacids.
- Photocatalytic,
- Multi-component reaction,
- Carbonthioesterification,
- Quinoxalinone-containing thioesters,
- Elemental sulfur
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