Citation: Huanan Zeng, Yue Wu, Yang Liu, Ziwen Wang, Jun Chen, Qingmin Wang. Recent advances of meta-diamide derivatives as insecticides targeting GABA receptor[J]. Chinese Chemical Letters, ;2026, 37(7): 112308. doi: 10.1016/j.cclet.2025.112308 shu

Recent advances of meta-diamide derivatives as insecticides targeting GABA receptor

Huanan Zeng ^a ,
Yue Wu ^a ,
Yang Liu ^a ,
Ziwen Wang ^{a, b} ,
Jun Chen ^{a, c, *,} ,
Qingmin Wang ^{a, *,}

a.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of ElementoOrganic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China
b.
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300071, China
c.
Department of Lung Cancer Surgery, Center of Thoracic Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China

Huntercj2004@qq.com

wangqm@nankai.edu.cn

Received Date: 24 September 2025
Revised Date: 10 December 2025
Accepted Date: 21 December 2025
Available Online: 23 December 2025

Figures(9)

Broflanilide is the first listed meta-diamide insecticide, which has shown potential in the field of pesticide research and development due to its unique structure and mechanism of action. The key to the development of the meta-diamide insecticides is the derivatization of various sites in the meta-diamide compounds. It is of great research significance to develop highly effective, broad spectrum, safe, and environmentally compatible meta-diamide insecticide using Broflanilide as a lead compound to obtain structurally diverse meta-diamide compounds. An overview of meta-diamide derivatives from the perspectives of insecticidal activities and mechanism of action is offered. Their potentials as a dominant active structure for development of insecticides are also discussed.
- Broflanilide,
- meta-Diamide,
- Insecticidal activity,
- Mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142