Citation: Weixia Ye, Kai Liu, Wei Liu, Xianbo Chen, Xuemin Ding, Haiyan Tian, Wenjun Zhang, Changsheng Zhang. Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains[J]. Chinese Chemical Letters, ;2026, 37(12): 112293. doi: 10.1016/j.cclet.2025.112293 shu

Novel lipopeptides featuring unusual C–C and C–N linkages between cyclic peptides and fatty acyl chains

Weixia Ye ^{a, b} ,
Kai Liu ^a ,
Wei Liu ^a ,
Xianbo Chen ^b ,
Xuemin Ding ^{a, c} ,
Haiyan Tian ^{b, *,} ,
Wenjun Zhang ^{a, c, *,} ,
Changsheng Zhang ^{a, c, *,}

a.
State Key Laboratory of Tropical Oceanography, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
b.
Institute of Traditional Chinese Medicine and Natural Products, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China

thytian@jnu.edu.cn

wzhang@scsio.ac.cn

czhang@scsio.ac.cn

Received Date: 14 October 2025
Revised Date: 15 December 2025
Accepted Date: 16 December 2025
Available Online: 17 December 2025

Figures(5)

Lipounguisins (LPUs) A‒K (9‒19), eleven novel lipopeptides were isolated from the sponge-associated fungus Aspergillus sp. SCSIO 40435. LPUs represent a rare class of lipopeptides (LPs), featuring cyclic heptapeptides conjugated to diverse octadecadienoic acids (either trans Δ¹⁰, Δ¹² or trans Δ⁹, Δ¹¹) via a C‒C or C‒N bond, and showed bioactivities including anti-Gram-positive bacteria, inhibitory activity of α-glucosidase, and cytotoxicity to Huh-7 (half-maximal inhibitory concentration (IC₅₀) = 5.42 µmol/L). A radical-mediated coupling reaction between unguisins and octadecadienoic acids was proposed to account for LPU formation.
- Dracaena cochinchinensis,
- Aspergillus sp.,
- Unguisins,
- Lipounguisins A‒K,
- Inhibitory activity of α-glucosidase
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