Citation: Tingting Du, Siyu Lu, Dong Wang, Jian Zhang, Jixiang Chen. Recent advances of imidazole derivatives in pesticide chemistry[J]. Chinese Chemical Letters, ;2026, 37(7): 112280. doi: 10.1016/j.cclet.2025.112280 shu

Recent advances of imidazole derivatives in pesticide chemistry

Tingting Du ^a ,
Siyu Lu ^a ,
Dong Wang ^{b, *,} ,
Jian Zhang ^{a, *,} ,
Jixiang Chen ^{a, *,}

a.
State Key Laboratory of Green Pesticide, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China
b.
Key Laboratory of Biopesticide Creation and Resource Utilization in Inner Mongolia Autonomous Region, Inner Mongolia Agricultural University, Hohhot 010018, China

wangdong@imau.edu.cn

jianzhang@gzu.edu.cn

jxchen@gzu.edu.cn

Received Date: 18 September 2025
Revised Date: 1 December 2025
Accepted Date: 12 December 2025
Available Online: 13 December 2025

Figures(18)

Imidazole derivatives exhibit broad-spectrum agricultural biological activities and serve as important molecular scaffolds in the discovery of new pesticides, particularly novel herbicides and fungicides. In recent years, there have been rapid developments in the research of imidazole-derived agricultural chemicals, such as the discovery of imidazole herbicides and fungicides. Therefore, it is significant to provide a review and update on the latest advances in the discovery of imidazole derivatives for pesticide development. Based on this, we systematically reviewed the latest research progress of imidazole derivatives in pesticide discovery, summarized the antiviral, insecticidal, nematicidal, and antibacterial activities of imidazole compounds, analyzed the synthetic methods of representative imidazole compounds, and discussed the active moieties, pharmacophores, structure-activity relationships (SAR), and mechanisms of action. This review aims to provide novel insights and inspiration for the discovery of novel imidazole pesticides.
- Imidazole,
- Biological activity,
- Active fragments,
- Synthesis method,
- Mechanism
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沈阳化工大学材料科学与工程学院沈阳 110142