Citation: Ji Ai, Hankun Zhang, Yanru Huang, Peijun Yang, Xin-Dong Jiang, Gaowu Qin, Xiangzhi Song. Terthienyl dependence of twisted conjugate in NIR-Ⅱ aza-BODIPY for photodynamic-photothermal therapy of cervical cancer[J]. Chinese Chemical Letters, ;2026, 37(11): 112276. doi: 10.1016/j.cclet.2025.112276 shu

Terthienyl dependence of twisted conjugate in NIR-Ⅱ aza-BODIPY for photodynamic-photothermal therapy of cervical cancer

Ji Ai ^{a, 1} ,
Hankun Zhang ^{b, 1} ,
Yanru Huang ^a ,
Peijun Yang ^a ,
Xin-Dong Jiang ^{a, *,} ,
Gaowu Qin ^{a, *,} ,
Xiangzhi Song ^{b, *,}

a.
Institute for Strategic Materials and Components, Shenyang University of Chemical Technology, Shenyang 110142, China
b.
College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, China

xdjiang@syuct.edu.cn

gwqin@syuct.edu.cn

xzsong@csu.edu.cn

Received Date: 3 September 2025
Revised Date: 11 December 2025
Accepted Date: 12 December 2025
Available Online: 13 December 2025

Figures(6)

The second near-infrared (NIR-Ⅱ) phototherapy agent has the advantages of optical imaging, non-invasive treatment mode and high photothermal conversion efficiency. Herein, a novel 3,5-trithienyl-substituted aza-boron-dipyrromethene (aza-BODIPY) (TerS-BDP) was synthesized via site-specific terthienyl functionalization at the 3,5-positions. According to X-ray single crystal analysis, TerS-BDP is an extremely twisted configuration, which is beneficial for intersystem crossing (ISC) to produce reactive oxygen species (ROS). In addition, the self-assembled TerS-BDP nanoparticles (TerS-BDP NPs) displayed excellent photothermal conversion efficiency (η = 62%), and can induce apoptosis of tumor cells through the combination of photothermal therapy and photodynamic therapy. This design strategy of terthienyl segment for NIR-Ⅱ aza-BODIPY provides a new idea and method for the study of phototherapy.
- Aza-BODIPY,
- Terthienyl group,
- NIR-Ⅱ,
- PDT,
- PTT,
- Twisted conjugate
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