Citation: Lihua Mo, Hang Wu, Yu Zhang, Tengyan Xu, Yuanzhi Zhong, Zhimou Yang. A dissipative hydrogel formed by peptide-carbon dioxide interaction[J]. Chinese Chemical Letters, ;2026, 37(11): 112247. doi: 10.1016/j.cclet.2025.112247 shu

A dissipative hydrogel formed by peptide-carbon dioxide interaction

Lihua Mo ^a ,
Hang Wu ^a ,
Yu Zhang ^b ,
Tengyan Xu ^a ,
Yuanzhi Zhong ^{b, *,} ,
Zhimou Yang ^{a, b, *,}

a.
Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, Department of Gastrointestinal Surgery, The first Affiliated Hospital, Wenzhou Medical University, Wenzhou 325035, China
b.
State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300073, China

1120220696@mail.nankai.edu.cn

yangzm@nankai.edu.cn

Received Date: 19 October 2025
Revised Date: 8 December 2025
Accepted Date: 9 December 2025
Available Online: 10 December 2025

Figures(5)

Responsive peptide-based hydrogels have attracted considerable attention for applications in drug delivery, diagnostics, and catalysis; however, most stimuli reported to date operate in the liquid or solid phase. Here, we report a tyrosine-based self-assembling peptide (Npx-YYY) that undergoes selective hydrogel formation in response to CO₂ gas. The resulting dissipative hydrogel is formed through reversible peptide–CO₂ interactions and holds promise for applications in catalysis as well as CO₂ capture and release.
- Self-assembly,
- CO₂-responsive,
- Peptide,
- Hydrogel,
- Dissipative
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