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Citation: Mei Wang, Kai Song, Yuning Song, Haiyong Jia, Peng Zhan. Advances in nucleotide metabolism-targeted drug research[J]. Chinese Chemical Letters, ;2026, 37(7): 112238. doi: 10.1016/j.cclet.2025.112238 shu

Advances in nucleotide metabolism-targeted drug research

Mei Wang ^{a, 1} ,
Kai Song ^{a, 1} ,
Yuning Song ^{b, *,} ,
Haiyong Jia ^{c, *,} ,
Peng Zhan ^{a, *,}

a.
Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China
b.
Department of Pharmacy, Qilu Hospital of Shandong University, Ji’nan 250012, China
c.
School of Pharmacy, Shandong Second Medical University, Weifang 261053, China

^*

syncat827@163.com

502378774@163.com

zhanpeng1982@sdu.edu.cn

¹

Received Date: 24 September 2025
Revised Date: 5 December 2025
Accepted Date: 8 December 2025
Available Online: 9 December 2025

Figures(2)

1. [1]
  Q. Gong, J. Song, Y. Song, et al., Chin. Chem. Lett. 36 (2025) 110456. doi: 10.1016/j.cclet.2024.110456
2. [2]
  T. Yang, X. Shi, S. Li, et al., Biomed. Pharmacother. 166 (2023) 115314. doi: 10.1016/j.biopha.2023.115314
3. [3]
  H. Zhang, N. Santana-Codina, Q. Yu, et al., Nat. Commun. 16 (2025) 6987. doi: 10.1038/s41467-025-61242-x
4. [4]
  F. Zeng, S. Li, G. Yang, et al., Acta Pharm. Sin. B 11 (2021) 795–809. doi: 10.1016/j.apsb.2020.10.008
5. [5]
  D.A. Lamprecht, R.J. Wall, A. Leemans, et al., Nature 644 (2025) 214–220. doi: 10.1038/s41586-025-09177-7
6. [6]
  M.J. Gong, L.S.F. Li, Y.Y. Chang, et al., Biomed. Pharmacother. 118 (2019) 109305. doi: 10.1016/j.biopha.2019.109305
1. [1]
  Chengying Wang , Bohan Chen , Yuming Wang , Bingyu Xie , Peishuang Yu , Xiaojie Xu , Rui Wang , Lin Miao , Xiaohui Yan , Yubo Li , Yunfei Li , Wei Huang . Advances of nanomedicine targeting the interface of cholesterol metabolism and immune evasion. Chinese Chemical Letters, 2025, 36(12): 110921-. doi: 10.1016/j.cclet.2025.110921
2. [2]
  Yue Xu , Lingzhi Wang , Liu Yang , Renliang Xue , Haowen Zhu , Qifeng Liu , Xueqi Lv , Ruiping Zhang , Jun Tu , Qingce Zang , Yinghong Wang . Spatial metabolomics combined with transcriptomics to reveal heterogeneous metabolism and drug response in the heart of rats with heart failure. Chinese Chemical Letters, 2025, 36(7): 110958-. doi: 10.1016/j.cclet.2025.110958
3. [3]
  Bohan Chen , Liming Gong , Jing Feng , Mingji Jin , Liqing Chen , Zhonggao Gao , Wei Huang . Research advances of nanoparticles for CAR-T therapy in solid tumors. Chinese Chemical Letters, 2024, 35(9): 109432-. doi: 10.1016/j.cclet.2023.109432
4. [4]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
5. [5]
  Cheng Wang , Ji Wang , Dong Liu , Zhi-Ling Zhang . Advances in virus-host interaction research based on microfluidic platforms. Chinese Chemical Letters, 2024, 35(12): 110302-. doi: 10.1016/j.cclet.2024.110302
6. [6]
  Jia-Lun Duan , Xin-Lan Zhang , Li-Qiang Zhao , Ya-Nan Liu , An-Ni Yao , Nian-Guang Li , Jin-Ao Duan , Chun-Jie Bao . Macrophage membrane-camouflaged nanoparticles for targeted drug delivery. Chinese Chemical Letters, 2026, 37(7): 111610-. doi: 10.1016/j.cclet.2025.111610
7. [7]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
8. [8]
  Yan Yu , Cailing Gan , Kun Shi , Zhongwu Bei , Yang Yu , Meng Pan , Hanzhi Deng , Zhiyong Qian . Recent advances in drug delivery systems for pulmonary fibrosis therapy. Chinese Chemical Letters, 2026, 37(1): 111596-. doi: 10.1016/j.cclet.2025.111596
9. [9]
  Guanlong Li , Zhuoyan Li , Yan Sun , Tiange Bu , Shaochuan Chen , Leixin Yang , Zhi Li , Wenyue Mao , Yanpeng Jia . Advances in CNS drug delivery strategies to cross the blood-brain barrier. Chinese Chemical Letters, 2026, 37(1): 111524-. doi: 10.1016/j.cclet.2025.111524
10. [10]
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11. [11]
  Youpeng Wang , Yuan Ji , Chengbo Li , Zhaoyang Chen , Xu Li , Tingting Zheng , Qiu Jiang , Chuan Xia . Advances in platinum-based materials for electrocatalytic ammonia oxidation: Mechanisms and research progress. Chinese Chemical Letters, 2025, 36(9): 110370-. doi: 10.1016/j.cclet.2024.110370
12. [12]
  Luqing Zhao , Dan Dou , Di Zhang , Shuqing Wang , Xihan Zhu , Ning Ding , Shengsheng Zhang , Chao Li . Nanotechnology-based natural remedies: Advancing inflammatory bowel disease treatment through targeted drug delivery. Chinese Chemical Letters, 2026, 37(5): 111262-. doi: 10.1016/j.cclet.2025.111262
13. [13]
  Kun Shang , Yinghua Lv , Yibo Yang , Senyu Yang , Zelong Chen , Ke Yang , Cong Li , Shuang Chao , Yuchao Lu , Yuxin Pei , Zhichao Pei . "Dual sweet" supramolecular glycosyl-nanoproteins based on carbohydrate-protein interaction for targeted drug delivery in vivo. Chinese Chemical Letters, 2026, 37(7): 111798-. doi: 10.1016/j.cclet.2025.111798
14. [14]
  Longhui Hao , Yi Zhang , Ying Sun , Yanqi Han , Jun Ye , Hongliang Wang , Lili Gao , Dong Wang , Yue Gao , Yanfang Yang , Yuling Liu . Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care. Chinese Chemical Letters, 2026, 37(7): 111597-. doi: 10.1016/j.cclet.2025.111597
15. [15]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
16. [16]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
17. [17]
  Gaojing Yang , Zhimeng Hao , Chun Fang , Wen Zhang , Xia-hui Zhang , Yuyu Li , Zhenhua Yan , Zhiyuan Wang , Tao Sun , Xiaofei Yang , Fei Wang , Chengzhi Zhang , Hongchang Jin , Shuaifeng Lou , Nan Chen , Yiju Li , Jia-Yan Liang , Le Yang , Shouyi Yuan , Jin Niu , Shuai Li , Xu Xu , Dong Wang , Song Jin , Bo-Quan Li , Meng Zhao , Changtai Zhao , Baoyu Sun , Xiaohong Wu , Yuruo Qi , Lili Wang , Nan Li , Bin Qin , Dong Yan , Xin Cao , Ting Jin , Peng Wei , Jing Zhang , Jiaojiao Liang , Li Liu , Ruimin Sun , Zengxi Wei , Xinxin Cao , Kaixiang Lei , Xiaoli Dong , Xijun Xu , Xiaohui Rong , Zhaomeng Liu , Hongbo Ding , Xuanpeng Wang , Zhanheng Yan , Guohui Qin , Guanghai Chen , Yaxin Chen , Ping Nie , Zhi Chang , Fang Wan , Minglei Mao , Zejing Lin , Anxing Zhou , Qiubo Guo , Wen Luo , Xiaodong Shi , Yan Guo , Longtao Ma , Xiangkun Ma , Jiangjiang Duan , Zhizhang Yuan , Jiafeng Lei , Hao Fan , Jinlin Yang , Chao Li , Tong Zhou , Jiabiao Lian , Jin Zhao , Huanxin Ju , Tinglu Song , Zulipiya Shadike , Weiguang Lv , Jiawei Wen , Lingxing Zeng , Jianmin Ma . Research progress and perspectives on rechargeable batteries. Chinese Chemical Letters, 2025, 36(10): 111185-. doi: 10.1016/j.cclet.2025.111185
18. [18]
  Peisi Xie , Jing Chen , Yongjun Xia , Zongwei Cai . MALDI and MALDI-2 mass spectrometry imaging contribute to revealing the alternations in lipid metabolism in germinating soybean seeds. Chinese Chemical Letters, 2025, 36(8): 110595-. doi: 10.1016/j.cclet.2024.110595
19. [19]
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20. [20]
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