Citation: Binhong Jiang, Yongjin Zhang, Donghua He, Zhendong Feng, Hongxu Liu, Kun Zhang, Guohua Liu. Mechanoredox-mediated hydroacylation of dialkyl azodicarboxylates by piezoelectric catalysis[J]. Chinese Chemical Letters, ;2026, 37(10): 112233. doi: 10.1016/j.cclet.2025.112233 shu

Mechanoredox-mediated hydroacylation of dialkyl azodicarboxylates by piezoelectric catalysis

International Joint Laboratory on Resource Chemistry of the Ministry of Education, Shanghai Engineering Research Center of Green Energy Chemical Engineering, Shanghai Normal University, Shanghai 200234, China

zhangkun@shnu.edu.cn

ghliu@shnu.edu.cn

Received Date: 8 June 2025
Revised Date: 29 November 2025
Accepted Date: 8 December 2025
Available Online: 9 December 2025

Figures(5)

The integration of mechanochemistry and piezocatalysis can open new strategies for driving redox reactions used in synthetic chemistry. However, due to the complex interplay between mechanical forces and surface charges, it remains challenging to design piezocatalysts based on a clear understanding of their catalytic mechanisms. Herein, by utilizing conventional BaTiO₃ as a piezoelectric material, we explore the hydroacylation of dialkyl azodicarboxylates for the synthesis of acyl hydrazides to gain insights into the piezoelectric material-mediated conversion process. Control experiments and mechanistic studies revealed that the reaction follows a pathway where mechanical activation induces polarization in the piezoelectric material, promoting benzoyl radical generation, which subsequently undergoes radical addition to acylhydrazine derivatives, leading to the formation of acylhydrazides. The collaborative contributions of piezoelectric activation and mechanical milling in the reaction between aldehydes and dialkyl azodicarboxylates enable the synthesis of a broad range of acyl hydrazides with excellent yields. This efficient and sustainable strategy provides valuable insights for theoretical guidance in designing piezocatalysis for future applications.
- Mechanochemistry,
- Piezoelectric catalysis,
- Solvent-free,
- Hydroacylation,
- Acylhydrazides
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