Citation: Xiao Zhao, Hexuan Wang, Yifei Chi, Wenru Shen, Xingchen Lu, Jingbo Wu, Zhiwen Zhang. Bioinspired fibrin hydrogel loading nanoparticles targets postoperative residual lesion for glioblastoma therapy[J]. Chinese Chemical Letters, ;2026, 37(11): 112232. doi: 10.1016/j.cclet.2025.112232 shu

Bioinspired fibrin hydrogel loading nanoparticles targets postoperative residual lesion for glioblastoma therapy

Xiao Zhao ^{a, b, 1} ,
Hexuan Wang ^{a, 1} ,
Yifei Chi ^a ,
Wenru Shen ^a ,
Xingchen Lu ^a ,
Jingbo Wu ^{b, *,} ,
Zhiwen Zhang ^{a, b, c, *,}

a.
School of Pharmaceutical Sciences, Key laboratory of smart drug delivery (Ministry of Education), MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai 201203, China
b.
Department of Pathology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
c.
Quzhou Fudan Institute, Quzhou 324002, China

wujingbo@fudan.edu.cn

zhangzhiwen@fudan.edu.cn

Received Date: 9 July 2025
Revised Date: 6 December 2025
Accepted Date: 8 December 2025
Available Online: 8 December 2025

Figures(5)

Because of the high aggressiveness and particularity of glioblastoma (GBM), the post-surgical minimal residual lesion is usually unavoidable and represents a crucial factor to the postoperative recurrence. Upon their combination with chemotherapy, the targeted delivery of therapeutic agents to the residual lesion is greatly challenged, ultimately causing the unfavorable prognosis. Inspired by the histopathological features of GBM tumors, a bioinspired fibrin hydrogel (FHL) system loading natural albumin nanoparticles was optimized from 4 different formulations by characterizing the targeting and penetrating ability in the postoperative residual lesion of GL261-induced GBM model. After surgical resection of GBM tumors, the intracranial injection of FHL loading albumin-paclitaxel nanoparticles exhibited specific targeting and notable intratumor penetration in the residual lesion, thereby significantly retarding the tumor relapse and producing a 2.16-fold prolongation of survival time. Therefore, the bioinspired FHL loading albumin nanoparticles provides an encouraging targeted delivery platform for postoperative GBM therapy.
- Glioblastoma,
- Intracranial delivery,
- Fibrin hydrogel,
- Tumor penetration,
- Postoperative relapse
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