Citation: Chongzhi Ye, Lishan Wang, Yunan Gao, Zhiai Rui, Qing He, Yujing Zhang, Hongwei Si, Pei Pei, Wanni Wang. Engineering probiotics for inflammatory bowel disease: Strategies and perspectives[J]. Chinese Chemical Letters, ;2026, 37(11): 112219. doi: 10.1016/j.cclet.2025.112219 shu

Engineering probiotics for inflammatory bowel disease: Strategies and perspectives

Chongzhi Ye ^{a, c, 1} ,
Lishan Wang ^{c, d, 1} ,
Yunan Gao ^{e, 1} ,
Zhiai Rui ^d ,
Qing He ^c ,
Yujing Zhang ^c ,
Hongwei Si ^{c, *,} ,
Pei Pei ^{c, *,} ,
Wanni Wang ^{a, b, *,}

a.
Department of Radiology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
b.
School of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei 230032, China
c.
Department of Nuclear Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
d.
First School of Clinical Medicine, Anhui Medical University, Hefei 230032, China
e.
Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

sihongwei@ahmu.edu.cn

ppei@ahmu.edu.cn

wnwang@ahmu.edu.cn

Received Date: 6 July 2025
Revised Date: 3 December 2025
Accepted Date: 4 December 2025
Available Online: 5 December 2025

Figures(7)

The pathogenesis of inflammatory bowel disease (IBD) is complex and multifactorial, involving intestinal microbiota imbalance, immune system abnormalities, genetic predispositions, and other factors. Therefore, the attainment of a complete cure for IBD through a single therapeutic modality remains a formidable challenge. In recent years, probiotics have received considerable attention in the treatment of IBD due to their properties of regulating intestinal microecology, immune activation, anti-infection and metabolic regulation. In order to further improve the safety, efficacy and clinical translation prospects of probiotics in the treatment of IBD, the engineering modification of probiotics has become the current research focus. In this review, we systematically summarize the probiotic species with promising clinical applications. Subsequently, the primary methods of engineering modifications (physical, chemical, genetic, etc.) are described and the role of these methods and their mechanisms in the treatment of IBD using engineered probiotics are discussed. Finally, we explore in depth the current challenges in the field and proposes potential future solutions. This review aims to present a comprehensive perspective on the development of a new generation of engineered probiotics and their application in IBD therapy.
- Probiotics,
- Engineering modifications,
- IBD,
- Inflammation treatment,
- Engineered probiotics,
- Intestinal microenvironment
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