Citation: Sijun Diao, Xiaoyin Liu, Zhongyu Li, Shihong Zhu, Jiayu Yuan, Fujun Liu, Xiyue Lu, Huiyang Luo, Umar Farooq, Jun Wu, Jing Chen. Electroactive biomaterials in neural regeneration: Advances and therapeutic mechanisms[J]. Chinese Chemical Letters, ;2026, 37(11): 112205. doi: 10.1016/j.cclet.2025.112205 shu

Electroactive biomaterials in neural regeneration: Advances and therapeutic mechanisms

Sijun Diao ^{a, 1} ,
Xiaoyin Liu ^{a, c, 1} ,
Zhongyu Li ^{a, 1} ,
Shihong Zhu ^a ,
Jiayu Yuan ^d ,
Fujun Liu ^e ,
Xiyue Lu ^f ,
Huiyang Luo ^f ,
Umar Farooq ^a ,
Jun Wu ^{b, *,} ,
Jing Chen ^{a, *,}

a.
Department of Neurosurgery, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China
b.
Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China
c.
National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, China
d.
Postgraduate training base Alliance of Wenzhou Medical University (Zhejiang Cancer Hospital), Hangzhou 310022, China
e.
State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Department of Ophthalmology, Chengdu 610041, China
f.
Department of Anesthesiology, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

junwuhkust@ust.hk

chenjing6811@126.com

Received Date: 15 September 2025
Revised Date: 29 November 2025
Accepted Date: 1 December 2025
Available Online: 2 December 2025

Figures(4)

Neural damage remains a serious clinical challenge. While electrical stimulation (ES) is a potent strategy to promote repair, traditional implantable electrodes face issues of invasiveness, rigidity, and finite longevity. In recent years, electroactive biomaterials have emerged as a revolutionary platform to overcome these hurdles by seamlessly integrating bio-mimetic conductivity with tunable biological and mechanical properties. This review outlines the types, advantages and disadvantages, preparation methods, and progress of conductive biomaterials commonly employed in nerve repair, and focus on pioneering non-invasive self-generating systems based on piezoelectric, magnetoelectric, and biofuel cell technologies. In addition, based on the relevant electrophysiological properties of electroactive materials, we synthesize a unified framework for their mechanisms of action, elucidating how electroactive interfaces orchestrate regeneration through tripartite regulation: Cellular behavior, signaling pathways, and microenvironment regulation. Finally, we discuss ongoing challenges and future perspectives, particularly regarding biodegradation, clinical translation, and the integration of smart feedback systems. This review aims to serve as a foundational reference for guiding the rational design of next-generation electroactive therapies for neural repair.
- Conductive biomaterials,
- Electroactive materials,
- Neural regeneration,
- Nervous system injury,
- Noninvasive self-generating system
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沈阳化工大学材料科学与工程学院沈阳 110142