Citation: Hao Yu, Xiaoliang Qi, Yuxi Chen, Youjian Chen, Jinghui Zhang, Wei Dong, Jianliang Shen, Tian Jiang. A procyanidin/Fe₃O₄ nanoparticle-reinforced pullulan/chitosan hydrogel for treating diabetic wounds[J]. Chinese Chemical Letters, ;2026, 37(11): 112173. doi: 10.1016/j.cclet.2025.112173 shu

A procyanidin/Fe₃O₄ nanoparticle-reinforced pullulan/chitosan hydrogel for treating diabetic wounds

Hao Yu ^{a, 1} ,
Xiaoliang Qi ^{b, 1} ,
Yuxi Chen ^{c, 1} ,
Youjian Chen ^a ,
Jinghui Zhang ^a ,
Wei Dong ^{a, *,} ,
Jianliang Shen ^{b, *,} ,
Tian Jiang ^{d, *,}

a.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China
b.
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China
c.
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China
d.
Department of Clinical Laboratory, The First People's Hospital of Wenling, Affiliated Wenling Hospital, Wenzhou Medical University, Wenling 317500, China

weidong@njust.edu.cn

shenjl@wiucas.ac.cn

jiangtianhw@hotmail.com

Received Date: 26 September 2025
Revised Date: 24 November 2025
Accepted Date: 25 November 2025
Available Online: 25 November 2025

Figures(5)

Existing therapies for diabetic wounds often deliver insufficient outcomes. Bacterial infection, oxidative stress, and deficient vascularization during tissue regeneration critically impede recovery. To address this substantial unmet clinical need, we developed an injectable hydrogel biomaterial, named QDP1, specifically engineered to accelerate tissue regeneration in diabetic wounds. This formulation integrates a polysaccharide matrix combining quaternized chitosan with dialdehyde pullulan, augmented by procyanidin/Fe₃O₄ nanoparticles. Following localized administration, QDP1 promptly forms a protective hydrogel barrier. The dressing exhibits powerful antibacterial properties alongside efficient scavenging of harmful oxidative molecules. Together, these effects shift the wound milieu from chronic inflammation towards a constructive proliferative phase. A key benefit involves the hydrogel's intrinsic biodegradability post-treatment, ensuring complete clearance once fulfilling its regenerative role. Results from both in vitro experiments and preclinical models demonstrate that QDP1 significantly accelerates wound repair. As a novel therapeutic platform, QDP1 presents a notably hopeful strategy for diabetic wound management, ultimately improving patient outcomes for this challenging condition.
- Magnetic nanoparticles,
- Polysaccharides,
- Hydrogels,
- Anti-inflammatory,
- Diabetic wounds
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沈阳化工大学材料科学与工程学院沈阳 110142

A procyanidin/Fe3O4 nanoparticle-reinforced pullulan/chitosan hydrogel for treating diabetic wounds

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通讯作者: 陈斌, bchen63@163.com

A procyanidin/Fe₃O₄ nanoparticle-reinforced pullulan/chitosan hydrogel for treating diabetic wounds