Citation: Jiahao Huang, Yongfeng Lan, Lifa Chen, Xiaoxuan Guan, Rong Liang, Jiatong Liang, Ming Gao, Jialiang Gan, Yun Guo, Sen Zhang. Living therapeutics: Colorectal related diseases precision therapy with engineered organisms[J]. Chinese Chemical Letters, ;2026, 37(6): 112151. doi: 10.1016/j.cclet.2025.112151 shu

Living therapeutics: Colorectal related diseases precision therapy with engineered organisms

Jiahao Huang ^{a, b, 1} ,
Yongfeng Lan ^{a, c, 1} ,
Lifa Chen ^{a, b, 1} ,
Xiaoxuan Guan ^d ,
Rong Liang ^a ,
Jiatong Liang ^a ,
Ming Gao ^d ,
Jialiang Gan ^{a, b, *,} ,
Yun Guo ^{a, b, *,} ,
Sen Zhang ^{a, b, *,}

a.
Department of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China
b.
Guangxi Key Laboratory of Enhanced Recovery after Surgery for Gastrointestinal Cancer, Nanning 530021, China
c.
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
d.
Life Sciences, Guangxi Medical University, Nanning 530021, China

ganjialiang@gxmu.edu.cn

guoyun@gxmu.edu.cn

zs0771@126.com

Received Date: 17 June 2025
Revised Date: 20 November 2025
Accepted Date: 21 November 2025
Available Online: 21 November 2025

Figures(3)

Colorectal related diseases are generally benign and malignant diseases that occur within the colon, causing psychological disorders, nutrient absorption disorders, anemia, and life threatening conditions. The current treatment strategies for colorectal related diseases have been seriously hampered by unpredictable behaviors, safety risks and limited efficacy. Recent advances in the fields of synthetic biology and materials fabrication have enabled the development of engineered organisms with great controllability, targeted delivery capabilities, and high safety and efficacy for their therapy. In this review, we first analyze the mechanisms underlying the occurrence and development of colorectal related disease. Subsequently, we delved into the latest developments in the application of engineered organisms in the treatment of colorectal diseases, covering the potential regulatory mechanisms, and the exploration of clinical feasibility. Finally, we discuss the key challenges and future perspectives of this biotherapeutic approach, with a focus on achieving precise targeted therapy through the engineering design of organisms. This review aims to provide the valuable insights into the development of precision therapies for colorectal related diseases, and lay the foundation for their clinical management.
- Engineered organisms,
- Colorectal related diseases,
- Gut microbiota,
- Colorectal microenvironment,
- Immunoactivation,
- Synthetic biology
1. [1]
  E. Morgan, M. Arnold, A. Gini, et al., Gut 72 (2023) 338–344. doi: 10.1136/gutjnl-2022-327736
2. [2]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA Cancer J. Clin. 71 (2021) 209–249. doi: 10.3322/caac.21660
3. [3]
  M.H. Frank, B.J. Wilson, J.S. Gold, et al., Gastroenterology 160 (2021) 1947–1960. doi: 10.1053/j.gastro.2020.12.080
4. [4]
  L.H. Biller, D. Schrag, JAMA 325 (2021) 669–685. doi: 10.1001/jama.2021.0106
5. [5]
  M. Agrawal, K.H. Allin, F. Petralia, et al., Nat. Rev. Gastroenterol. Hepatol. 19 (2022) 399–409. doi: 10.1038/s41575-022-00593-y
6. [6]
  S.C. Ng, H.Y. Shi, N. Hamidi, et al., Lancet 390 (2017) 2769–2778. doi: 10.1016/S0140-6736(17)32448-0
7. [7]
  C. Abraham, M.T. Abreu, J.R. Turner, et al., Gastroenterology 162 (2022) 1602–1616. doi: 10.1053/j.gastro.2021.12.288
8. [8]
  E.J. Villablanca, K. Selin, C.R.H. Hedin, et al., Nat. Rev. Gastroenterol. Hepatol. 19 (2022) 493–507. doi: 10.1038/s41575-022-00604-y
9. [9]
  J.J. Rudbaek, M. Agrawal, J. Torres, et al., Nat. Rev. Gastroenterol. Hepatol. 21 (2024) 86–100. doi: 10.1038/s41575-023-00854-4
10. [10]
  L. Hracs, J.W. Windsor, J. Gorospe, et al., Nature 642 (2025) 458–466. doi: 10.1038/s41586-025-08940-0
11. [11]
  S. Massironi, C. Viganò, A. Palermo, et al., Lancet Gastroenterol. Hepatol. 8 (2023) 579–590. doi: 10.1016/S2468-1253(23)00011-0
12. [12]
  R. Sun, Y. Zhang, X. Zhao, et al., Adv. Sci. 12 (2025) e2412551. doi: 10.1002/advs.202412551
13. [13]
  S.C. Shah, S.H. Itzkowitz, Gastroenterology 162 (2022) 715–730. doi: 10.1053/j.gastro.2021.10.035
14. [14]
  Y. Guo, Y. Zhu, J. Zhang, et al., Acta Pharm. Sin. B 15 (2025) 168–187. doi: 10.3390/inorganics13050168
15. [15]
  K. Wang, J.E. Tepper, CA Cancer J. Clin. 71 (2021) 437–454. doi: 10.3322/caac.21689
16. [16]
  A. Soragni, E.S. Knudsen, T.N. O’Connor, et al., Nat. Rev. Cancer 25 (2025) 613–633. doi: 10.1038/s41568-025-00824-9
17. [17]
  H. Wang, W. Zhang, Y. Sun, et al., Bioact. Mater. 50 (2025) 61–94. doi: 10.1117/12.3083477
18. [18]
  L. Li, L. Dai, M. Lin, et al., Adv. Sci. 12 (2025) e2409711. doi: 10.1002/advs.202409711
19. [19]
  J. Ding, X. Zhao, S. Long, et al., Smart Mol. 3 (2025) e70014. doi: 10.1002/smo2.70014
20. [20]
  Z. Zhou, Y. Chen, Y. Ba, et al., Cell Prolif. 58 (2025) e13791. doi: 10.1111/cpr.13791
21. [21]
  J. Yu, S. Li, B. Xiong, et al., Adv. Mater. 37 (2025) e2412429. doi: 10.1002/adma.202412429
22. [22]
  J. Xie, M. Liu, X. Deng, et al., iMeta 3 (2024) e156. doi: 10.1002/imt2.156
23. [23]
  M. Bae, C.D. Cassilly, X. Liu, et al., Nature 608 (2022) 168–173. doi: 10.1038/s41586-022-04985-7
24. [24]
  S.Y. Lee, J. Jhun, J.S. Woo, et al., Gut Microbes 16 (2024) 2300846. doi: 10.1080/19490976.2023.2300846
25. [25]
  Y. Che, G. Chen, Q. Guo, et al., Hepatology 78 (2023) 88–102. doi: 10.1097/hep.0000000000000047
26. [26]
  J. Guo, X. Zhu, B. Liang, et al., Nano TransMed 4 (2025) 100079. doi: 10.1016/j.ntm.2025.100079
27. [27]
  Y.R. Li, Y. Zhu, T. Halladay, L. Yang, Nat. Rev. Immunol. 25 (2025) 725–744. doi: 10.1038/s41577-025-01174-1
28. [28]
  H.X. Wu, Y.Q. Pan, Y. He, et al., J. Clin. Oncol. 41 (2023) 1735–1746. doi: 10.1200/jco.22.01490
29. [29]
  S.M. Blum, D.A. Zlotoff, N.P. Smith, et al., Nature 636 (2024) 215–223. doi: 10.1038/s41586-024-08105-5
30. [30]
  M. Ambrosini, P. Manca, V. Nasca, et al., Nat. Rev. Clin. Oncol. 22 (2025) 385–407. doi: 10.1038/s41571-025-01015-z
31. [31]
  Y.C. Luo, X.T. Huang, R. Wang, et al., Mil. Med. Res. 12 (2025) 38. doi: 10.1287/ijoo.2022.0030
32. [32]
  Q. Lei, H. Deng, S. Sun, Life Med. 4 (2025) lnaf002. doi: 10.1093/lifemedi/lnaf002
33. [33]
  Y. Xing, J. Yang, A. Peng, et al., Adv. Mater. 36 (2024) e2412730. doi: 10.1002/adma.202412730
34. [34]
  Y. Fu, B. Duan, P. Zheng, et al., Biomaterials 324 (2026) 123524. doi: 10.1016/j.biomaterials.2025.123524
35. [35]
  J. Xu, L. Ding, J. Mei, et al., Signal Transduct. Target. Ther. 10 (2025) 268. doi: 10.3390/land14020268
36. [36]
  H. Tang, Z. Wei, B. Zheng, et al., Nature 645 (2025) 244–253. doi: 10.1038/s41586-025-09202-9
37. [37]
  J. Song, R. Wei, C. Liu, et al., Nat. Commun. 16 (2025) 2175. doi: 10.1038/s41467-025-57465-7
38. [38]
  G. Caligiuri, D.A. Tuveson, Cancer Cell 41 (2023) 434–449. doi: 10.1016/j.ccell.2023.02.015
39. [39]
  H. Jia, X. Chen, L. Zhang, et al., J. Hematol. Oncol. 18 (2025) 36. doi: 10.1186/s13045-025-01688-0
40. [40]
  M.F. Neurath, D. Artis, C. Becker, Lancet Gastroenterol. Hepatol. 10 (2025) 573–592. doi: 10.1016/S2468-1253(24)00390-X
41. [41]
  J.P. Auger, M. Zimmermann, M. Faas, et al., Nature 629 (2024) 184–192. doi: 10.1038/s41586-024-07282-7
42. [42]
  Z. Wang, L. Tian, Y. Jiang, et al., Cell Metab. 37 (2025) 1089–1102. doi: 10.1016/j.cmet.2025.01.007
43. [43]
  M.F. Neurath, Sci. Transl. Med. 14 (2022) eabq4473. doi: 10.1126/scitranslmed.abq4473
44. [44]
  B. Verstockt, A. Salas, B.E. Sands, et al., Nat. Rev. Gastroenterol. Hepatol. 20 (2023) 433–446. doi: 10.1038/s41575-023-00768-1
45. [45]
  M. Wang, Q. Huang, M. Liu, et al., Adv. Mater. 35 (2023) e2309370. doi: 10.1002/adma.202309370
46. [46]
  A. Picca, J. Faitg, J. Auwerx, et al., Nat. Metab. 5 (2023) 2047–2061. doi: 10.1038/s42255-023-00930-8
47. [47]
  J. Debnath, N. Gammoh, K.M. Ryan, Nat. Rev. Mol. Cell Biol. 24 (2023) 560–575. doi: 10.1038/s41580-023-00585-z
48. [48]
  D. Kotani, E. Oki, Y. Nakamura, et al., Nat. Med. 29 (2023) 127–134. doi: 10.1038/s41591-022-02115-4
49. [49]
  J. Zhang, C.M. Simpson, J. Berner, et al., Cell 186 (2023) 2361-2379.e2325. doi: 10.1016/j.cell.2023.04.026
50. [50]
  J. Yang, Y. Yamashita-Kanemaru, B.I. Morris, et al., Nature 640 (2025) 1052–1061. doi: 10.1038/s41586-025-08626-7
51. [51]
  M. Derks, M.C. Bryan, C. Rockx, et al., Blood 142 (2023) 2824. doi: 10.1182/blood-2023-188516
52. [52]
  A. Larrañaga-SanMiguel, N. Bengoa-Vergniory, H. Flores-Romero, Trends Cell Biol. 35 (2025) 33–45. doi: 10.1016/j.tcb.2024.08.007
53. [53]
  K. Newton, A. Strasser, N. Kayagaki, et al., Cell 187 (2024) 235–256. doi: 10.1016/j.cell.2023.11.044
54. [54]
  P. Broz, Cell Res. 35 (2025) 334–344. doi: 10.1038/s41422-025-01107-6
55. [55]
  H. Wang, P. Sun, X. Yuan, et al., Mol. Cancer 24 (2025) 85. doi: 10.1186/s12943-025-02277-y
56. [56]
  R.C. Russell, K.L. Guan, EMBO J. 41 (2022) e110031. doi: 10.15252/embj.2021110031
57. [57]
  J. Wu, X. Xu, J. Duan, et al., Nat. Commun. 15 (2024) 1282. doi: 10.1038/s41467-024-45539-x
58. [58]
  K.E. de Visser, J.A. Joyce, Cancer Cell 41 (2023) 374–403. doi: 10.1016/j.ccell.2023.02.016
59. [59]
  S. Guelfi, K. Hodivala-Dilke, G. Bergers, Nat. Rev. Cancer 24 (2024) 655–675. doi: 10.1038/s41568-024-00736-0
60. [60]
  S.S. Sunder, U.C. Sharma, S. Pokharel, Signal Transduct. Target. Ther. 8 (2023) 262. doi: 10.1038/s41392-023-01469-6
61. [61]
  S. Wang, M. Cheng, S. Wang, et al., Adv. Mater. 36 (2024) e2403921. doi: 10.1002/adma.202403921
62. [62]
  H. Zheng, J. Yu, L. Gao, et al., Nat. Commun. 16 (2025) 1826. doi: 10.1038/s41467-025-57124-x
63. [63]
  E. Rotman, S. McClure, J. Glazier, et al., Cell Host Microbe 32 (2024) 1988–2003. doi: 10.1016/j.chom.2024.09.004
64. [64]
  W. Jing, S. Dong, Y. Xu, et al., Acta Pharm. Sin. B 15 (2025) 205–223. doi: 10.1016/j.apsb.2024.11.009
65. [65]
  C. Li, Z.X. Wang, H. Xiao, et al., Adv. Mater. 36 (2024) e2310174. doi: 10.1002/adma.202310174
66. [66]
  Y. Wang, H. Yan, Q. Zheng, X. Sun, hLife 3 (2025) 364–385. doi: 10.1016/j.hlife.2025.01.001
67. [67]
  I.D. Iliev, A.N. Ananthakrishnan, C.J. Guo, Nat. Rev. Microbiol. 23 (2025) 509–524. doi: 10.1038/s41579-025-01163-0
68. [68]
  E.R. Mann, Y.K. Lam, H.H. Uhlig, Nat. Rev. Immunol. 24 (2024) 577–595. doi: 10.1038/s41577-024-01014-8
69. [69]
  H. Ji, X. Yan, L. Zhang, et al., J. Control. Release 380 (2025) 297–316. doi: 10.1016/j.jconrel.2025.01.059
70. [70]
  R. Nawfal, M. Noureldein, S. Bitar, et al., J. Clin. Oncol. 41 (2023) e15505. doi: 10.1200/jco.2023.41.16_suppl.e15505
71. [71]
  A. Nobels, C. van Marcke, B.F. Jordan, et al., Nat. Metab. 7 (2025) 895–917. doi: 10.1038/s42255-025-01287-w
72. [72]
  Y. Fu, J. Li, W. Cai, et al., Acta Pharm. Sin. B 14 (2024) 1560–1591. doi: 10.1016/j.apsb.2023.11.018
73. [73]
  M.T. White, C.L. Sears, Nat. Rev. Microbiol. 22 (2024) 240–254. doi: 10.1038/s41579-023-00973-4
74. [74]
  Y. Zhang, W. Song, L. Zhou, Gut 74 (2025) 1755–1758. doi: 10.1136/gutjnl-2025-335306
75. [75]
  Y. Chen, H. Fang, H. Chen, et al., Gut Microbes 17 (2025) 2464945. doi: 10.1080/19490976.2025.2464945
76. [76]
  A.C.Y. Su, X. Ding, H.C.H. Lau, et al., Gut 73 (2024) 1478–1488. doi: 10.1136/gutjnl-2023-330835
77. [77]
  H. Tian, X. Wang, Z. Fang, et al., Innovation 4 (2024) 100597.
78. [78]
  A. Chen-Liaw, V. Aggarwala, I. Mogno, et al., Nature 637 (2025) 422–429. doi: 10.1038/s41586-024-08242-x
79. [79]
  Y. Kim, G. Kim, S. Kim, et al., Cell Host Microbe 32 (2024) 1380–1393. doi: 10.1016/j.chom.2024.06.010
80. [80]
  T.M. Halsey, A.S. Thomas, T. Hayase, et al., Sci. Transl. Med. 15 (2023) eabq4006. doi: 10.1126/scitranslmed.abq4006
81. [81]
  O. DeLeon, M. Mocanu, A. Tan, et al., Cell 188 (2025) 3927–3941. doi: 10.1016/j.cell.2025.05.014
82. [82]
  T.S.B. Schmidt, S.S. Li, O.M. Maistrenko, et al., Nat. Med. 28 (2022) 1902–1912. doi: 10.1038/s41591-022-01913-0
83. [83]
  N.V. Terekhanova, A. Karpova, W.W. Liang, et al., Nature 623 (2023) 432–441. doi: 10.1038/s41586-023-06682-5
84. [84]
  I. RAkano, J.M. Hebert, R.L. Tiedemann, et al., Mol. Cell 85 (2025) 2885–2899. doi: 10.1016/j.molcel.2025.06.020
85. [85]
  W.W. Liang, R.J. Lu, R.G. Jayasinghe, et al., Cancer Cell 41 (2023) 1567–1585. doi: 10.1016/j.ccell.2023.07.013
86. [86]
  Y. Zhang, P. Naderi Yeganeh, H. Zhang, et al., Nat. Immunol. 25 (2024) 1858–1870. doi: 10.1038/s41590-024-01932-8
87. [87]
  M.J. Wu, H. Kondo, A.V. Kammula, et al., Science 385 (2024) eadl6173. doi: 10.1126/science.adl6173
88. [88]
  N. Niu, X. Shen, Z. Wang, et al., Cancer Cell 42 (2024) 869–884. doi: 10.1016/j.ccell.2024.03.005
89. [89]
  A. Zhuang, X. Gu, T. Ge, et al., Cancer Commun. 43 (2023) 1185–1206. doi: 10.1002/cac2.12471
90. [90]
  A. Eccleston, Nat. Rev. Drug Discov. 23 (2024) 250. doi: 10.1038/d41573-024-00046-y
91. [91]
  M. Coan, S. Haefliger, S. Ounzain, et al., Nat. Rev. Genet. 25 (2024) 578–595. doi: 10.1038/s41576-024-00693-2
92. [92]
  L.L. Chen, Cell 187 (2024) 6451–6485. doi: 10.1016/j.cell.2024.10.024
93. [93]
  K. Nemeth, R. Bayraktar, M. Ferracin, et al., Nat. Rev. Genet. 25 (2024) 211–232. doi: 10.1038/s41576-023-00662-1
94. [94]
  H. Yan, Y. Wen, Z. Tian, et al., Nat. Biomed. Eng. 7 (2023) 1583–1601. doi: 10.1038/s41551-023-01033-1
95. [95]
  F. Zhai, B. Yun, J. Ming, et al., Adv. Mater. 37 (2025) e2501378. doi: 10.1002/adma.202501378
96. [96]
  R.L. Siegel, N.S. Wagle, A. Cercek, et al., CA Cancer J. Clin. 73 (2023) 233–254. doi: 10.3322/caac.21772
97. [97]
  F. Bray, M. Laversanne, H. Sung, et al., CA Cancer J. Clin. 74 (2024) 229–263. doi: 10.3322/caac.21834
98. [98]
  C. Lynch, S.P. Pitroda, R.R. Weichselbaum, Lancet Oncol. 25 (2024) e352–e362. doi: 10.1016/S1470-2045(24)00075-5
99. [99]
  F. Tong, H. Li, H. Gao, Y. Li, Acta Pharm. Sin. B 15 (2025) 4316–4318. doi: 10.1016/j.apsb.2025.05.033
100. [100]
  S.B. Deverly, B. Raffy, T. Ratovomanana, et al., J. Clin. Oncol. 43 (2025) 272. doi: 10.1200/JCO.2025.43.4_suppl.272
101. [101]
  D.C. Baumgart, W.J. Sandborn, Lancet 369 (2007) 1641–1657. doi: 10.1016/S0140-6736(07)60751-X
102. [102]
  G.G. Kaplan, Nat. Rev. Gastroenterol. Hepatol. 22 (2025) 708–720. doi: 10.1038/s41575-025-01097-1
103. [103]
  R. Mao, M. Chen, Lancet Gastroenterol. Hepatol. 19 (2022) 81–82. doi: 10.1038/s41575-021-00555-w
104. [104]
  P. Wangchuk, K. Yeshi, A. Loukas, Trends Pharmacol. Sci. 45 (2024) 892–903. doi: 10.1016/j.tips.2024.08.003
105. [105]
  G. D’Haens, M. Dubinsky, T. Kobayashi, et al., N. Engl. J. Med. 388 (2023) 2444–2455. doi: 10.1056/nejmoa2207940
106. [106]
  E. Louis, S. Schreiber, R. Panaccione, et al., JAMA 332 (2024) 881–897. doi: 10.1001/jama.2024.12414
107. [107]
  M. Ferrante, G. D’Haens, V. Jairath, et al., Lancet 404 (2024) 2423–2436. doi: 10.1016/S0140-6736(24)01762-8
108. [108]
  C. Kapizioni, R. Desoki, D. Lam, et al., J. Crohns Colitis 18 (2024) 790–800. doi: 10.1093/ecco-jcc/jjad203
109. [109]
  J.S. Lasa, P.A. Olivera, S. Danese, et al., Lancet Gastroenterol. Hepatol. 7 (2022) 161–170. doi: 10.1016/S2468-1253(21)00377-0
110. [110]
  H. He, X. Dong, L. Cao, et al., Bioact. Mater. 53 (2025) 32–44.
111. [111]
  E. Lou, M.S. Choudhry, T.K. Starr, et al., Lancet Oncol 26 (2025) 559–570. doi: 10.1016/S1470-2045(25)00083-X
112. [112]
  Y. Feng, C. Chen, A. Shao, et al., Chin. Chem. Lett. 36 (2025) 110963. doi: 10.1016/j.cclet.2025.110963
113. [113]
  E.E. Elemike, I.C. Onunkwo, O. Ughumiakpor, et al., Nano TransMed 4 (2025) 100076. doi: 10.1016/j.ntm.2025.100076
114. [114]
  F. Cao, L. Jin, Y. Gao, et al., Nat. Nanotechnol. 18 (2023) 617–627. doi: 10.1038/s41565-023-01346-x
115. [115]
  P. Zhou, Q. Sun, L. Huang, et al., ACS Nano 19 (2025) 31619–31642. doi: 10.1021/acsnano.5c08999
116. [116]
  W. Yi, F. Sun, X. Qian, et al., Adv. Mater. 37 (2025) e2420113. doi: 10.1002/adma.202420113
117. [117]
  M.I. Ahamed, Lutfullah Inamuddin, et al., J. Taiwan Inst. Chem. Eng. 68 (2016) 407–414. doi: 10.1016/j.jtice.2016.08.024
118. [118]
  Inamuddin Beenish, M.I. Ahamed, et al., Mater. Sci. Energy Technol. 1 (2018) 63–69.
119. [119]
  M. Sun, J. Yang, L. Li, et al., Chin. Chem. Lett. 36 (2025) 111093. doi: 10.1016/j.cclet.2025.111093
120. [120]
  R.M. Cooper, J.A. Wright, J.Q. Ng, et al., Science 381 (2023) 682–686. doi: 10.1126/science.adf3974
121. [121]
  C. Wang, L. Chen, J. Zhu, et al., Adv. Funct. Mater. 34 (2024) 2316092. doi: 10.1002/adfm.202316092
122. [122]
  J. Li, R. Yang, Y. Yuan, et al., Adv. Funct. Mater. 35 (2025) 2414994. doi: 10.1002/adfm.202414994
123. [123]
  Y.Z. Wang, W.H. Chen, Z.Y. Han, et al., Cell Metab. 37 (2025) 1277–1293. doi: 10.56434/j.arch.esp.urol.20257809.165
124. [124]
  D. Gumber, L.D. Wang, EBioMedicine 77 (2022) 103941. doi: 10.1016/j.ebiom.2022.103941
125. [125]
  L. Labanieh, R.G. Majzner, D. Klysz, et al., Cell 185 (2022) 1745–1763. doi: 10.1016/j.cell.2022.03.041
126. [126]
  F. Zhu, G. Nie, C. Liu, Life Med. 2 (2023) lnad027. doi: 10.1093/lifemedi/lnad027
127. [127]
  K. Lv, T. Wu, S. Liu, et al., Acta Pharm. Sin. B 14 (2024) 4526–4543. doi: 10.1016/j.apsb.2024.06.027
128. [128]
  D. Xiong, H. Yu, Z.-J. Sun, Acta Pharm. Sin. B 14 (2024) 3416–3431. doi: 10.1016/j.apsb.2024.04.022
129. [129]
  L. Yan, S. Gao, X. Wang, et al., hLife 2 (2024) 380–396. doi: 10.1016/j.hlife.2024.06.002
130. [130]
  B. Liu, J. Shen, Y. Wu, et al., Bioact. Mater. 52 (2025) 529–540.
131. [131]
  B. Chen, L. Gong, J. Feng, et al., Chin. Chem. Lett. 35 (2024) 109432. doi: 10.1016/j.cclet.2023.109432
132. [132]
  J. Chen, T. Zhu, G. Jiang, et al., Mol. Cancer 22 (2023) 131. doi: 10.1186/s12943-023-01830-x
133. [133]
  T.M. Müller, L.J. Liu, M. Wiesinger, et al., Gastroenterology 168 (2025) 389–392. doi: 10.1053/j.gastro.2024.10.003
134. [134]
  H. Wang, C.N. Alarcón, B. Liu, et al., Nat. Biomed. Eng. 6 (2022) 882–897.
135. [135]
  J. Svoboda, D.J. Landsburg, J. Gerson, et al., N. Engl. J. Med. 392 (2025) 1824–1835. doi: 10.1056/nejmoa2408771
136. [136]
  Y. Zhao, J. Chen, M. Andreatta, et al., Nat. Biotechnol. 42 (2024) 1693–1704. doi: 10.1038/s41587-023-02060-8
137. [137]
  Q. Yan, S. Li, Q. Yan, et al., Cell 187 (2024) 2969–2989. doi: 10.1016/j.cell.2024.04.043
138. [138]
  G. Luo, J. Zhang, T. Wang, et al., Cell Host Microbe 32 (2024) 1536–1551. doi: 10.1016/j.chom.2024.07.003
139. [139]
  D. Wu, Y.X. Guan, C.H. Li, et al., iMeta 3 (2024) e170. doi: 10.1002/imt2.170
140. [140]
  Q. Cheng, X. Quan, R. Luo, et al., Adv. Funct. Mater. 34 (2024) 2316701. doi: 10.1002/adfm.202316701
141. [141]
  Y. Zhang, D.W. Zheng, C.X. Li, et al., Small Methods 6 (2022) e2100951. doi: 10.1002/smtd.202100951
142. [142]
  Y.T. Qin, X. Liu, J.X. An, et al., ACS Nano 18 (2024) 23497–23507. doi: 10.1021/acsnano.4c07115
143. [143]
  T. Shen, X. Sun, S. Yang, et al., ACS Nano 18 (2024) 28212–28227. doi: 10.1021/acsnano.4c08044
144. [144]
  K. Hezaveh, R.S. Shinde, A. Klötgen, et al., Immunity 55 (2022) 324–340. doi: 10.1016/j.immuni.2022.01.006
145. [145]
  M.J. Bender, A.C. McPherson, C.M. Phelps, et al., Cell 186 (2023) 1846–1862. doi: 10.1016/j.cell.2023.03.011
146. [146]
  F.S. Fu, H.H. Chen, Y. Chen, et al., Bioact. Mater. 46 (2025) 503–515.
147. [147]
  J. Jiang, Y. Ma, L. Zhou, et al., Adv. Mater. 37 (2025) e2417050. doi: 10.1002/adma.202417050
148. [148]
  Z. Yang, Z. Jiao, Z. Chen, et al., Adv. Mater. 37 (2025) e2504206. doi: 10.1002/adma.202504206
149. [149]
  P. Guo, W. Wang, Q. Xiang, et al., Cell Host Microbe 32 (2024) 1502–1518. doi: 10.1016/j.chom.2024.07.028
150. [150]
  J. Gu, J. Gu, L. Yu, Chin. Chem. Lett. 36 (2025) 110727. doi: 10.1016/j.cclet.2024.110727
151. [151]
  P. Li, L. Zhu, C. Song, et al., ACS Nano 19 (2025) 14213–14232. doi: 10.1021/acsnano.5c00574
152. [152]
  T. Ma, G. Gan, J. Cheng, et al., Angew. Chem. Int. Ed. 64 (2025) e202502588. doi: 10.1002/anie.202502588
153. [153]
  N. Li, L. Li, B. He, et al., hLife 3 (2025) 275–283. doi: 10.1016/j.hlife.2025.03.004
154. [154]
  C. Wang, S. Wang, S. Jing, et al., Adv. Sci. 11 (2024) 2309972. doi: 10.1002/advs.202309972
155. [155]
  M. Ali, A. Khan, T.V. Nursimulu, J.A. Shin, Nucleic Acids Res. 53 (2025) gkaf746.
156. [156]
  C. Sun, J. Chen, M. Jin, et al., Adv. Sci. 10 (2023) e2302159. doi: 10.1002/advs.202302159
157. [157]
  P. Huss, K. Kieft, A. Meger, et al., Sci. Adv. 11 (2025) eadt6432. doi: 10.1126/sciadv.adt6432
158. [158]
  Z.R. Baker, Y. Zhang, H. Zhang, et al., Nat. Biotechnol. 44 (2026) 90–99. doi: 10.1038/s41587-025-02570-7
159. [159]
  D.W. Zheng, X. Dong, P. Pan, et al., Nat. Biomed. Eng. 3 (2019) 717–728. doi: 10.1038/s41551-019-0423-2
160. [160]
  M. Zepeda-Rivera, S.S. Minot, H. Bouzek, et al., Nature 628 (2024) 424–432. doi: 10.1038/s41586-024-07182-w
161. [161]
  H. Zhu, M. Li, D. Bi, et al., Nat. Commun. 15 (2024) 1688. doi: 10.1038/s41467-024-45572-w
162. [162]
  S. Lin, G. Xie, J. He, et al., Nat. Biomed. Eng. 9 (2025) 1155–1171. doi: 10.1038/s41551-025-01354-3
163. [163]
  J. Yang, Y. Wang, Y. Fu, et al., Interdiscip. Med. 3 (2025) e20240101. doi: 10.1002/INMD.20240101
164. [164]
  Y. Gao, J. Liu, M. Wu, et al., ACS Nano 19 (2025) 4251–4268. doi: 10.1021/acsnano.4c11024
165. [165]
  J. Mondal, S. Pillarisetti, V. Junnuthula, et al., J. Control. Release 353 (2023) 1127–1149. doi: 10.1016/j.jconrel.2022.12.027
166. [166]
  Y. Gan, Q. Hao, T. Han, et al., Adv. Sci. 11 (2024) e2407370. doi: 10.1002/advs.202407370
167. [167]
  Y. Wang, X. Guo, J. Qin, et al., Adv. Sci. 12 (2025) e2500139. doi: 10.1002/advs.202500139
168. [168]
  Q. Zhang, Y. Li, Q. Jin, et al., Chin. Chem. Lett. 37 (2026) 110964. doi: 10.1016/j.cclet.2025.110964
169. [169]
  Y.L. Jiang, G. Zhao, S.H. Wang, N. Li, Mil. Med. Res. 12 (2025) 31.
170. [170]
  Z.P. Sang, T. Xue, Q.R. Xing, et al., Chin. Chem. Lett. 37 (2026) 111318. doi: 10.1016/j.cclet.2025.111318
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9. [9]
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13. [13]
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