Citation: Ran Wang, Chang Tian, Entong Ji, Qixiang Wu, Jie Wang, Tao Xu. Research progress of LNP-based mRNA delivery system in the treatment of liver disease[J]. Chinese Chemical Letters, ;2026, 37(10): 112138. doi: 10.1016/j.cclet.2025.112138 shu

Research progress of LNP-based mRNA delivery system in the treatment of liver disease

Ran Wang ^{a, 1} ,
Chang Tian ^{a, 1} ,
Entong Ji ^{b, 1} ,
Qixiang Wu ^{a, 1} ,
Jie Wang ^{a, *,} ,
Tao Xu ^{a, c, *,}

a.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmaceutical Sciences, Anhui Medical University, Hefei 230032, China
b.
Department of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China
c.
Tongling People’s Hospital, Tongling 244000, China

wangjienar@163.com

xutao@ahmu.edu.cn

Received Date: 24 August 2025
Revised Date: 18 November 2025
Accepted Date: 19 November 2025
Available Online: 20 November 2025

Figures(4)

Liver disease remains one of the most prevalent health concerns, attracting significant attention for its treatment options. As an emerging technology, messenger RNA (mRNA) technology has shown remarkable potential in the biomedical field, with RNA drugs offering distinct advantages such as rapid onset, safety, multiple target options, and ease of clinical translation. However, the inherent instability and susceptibility to degradation of mRNA molecules pose significant challenges for efficient and targeted delivery. Nanotechnology offers innovative solutions to these challenges, not only overcoming physiological barriers but also significantly enhancing the efficacy of mRNA drugs. As an ideal strategy for treating liver diseases, lipid nanoparticle (LNP)-encapsulated mRNA can activate regenerative pathways in hepatocytes within a short time frame, facilitating the treatment of liver injuries from various causes. This review highlights recent advancements in LNP-based mRNA delivery systems for treating different liver diseases. It begins with an introduction to mRNA drugs and their delivery systems, followed by a discussion on the targeting capabilities of LNP. It also emphasizes the application of LNP-based mRNA delivery systems in treating liver diseases. Finally, It outlines the current challenges faced by LNP-based mRNA delivery systems in liver disease treatment and anticipates future applications in addressing liver-related disorders. It is hoped that these insights presented here will help to further improve the application of mRNA-LNP technology in disease treatment. This review aims to provide a reference for researchers and clinicians in related fields and promotes the further development of this technology.
- Liver,
- LNP,
- mRNA,
- Delivery system,
- Liver disease
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