Citation: Chunxian Zhou, Mingyu Gong, Jubo Jian, Huanhuan Pan, Wanshan Hu, Zeshi Jiang, Chao Lu, Guilan Quan, Chuanbin Wu, Xin Pan, Junhuang Jiang, Tingting Peng. Microneedle-mediated precision immunomodulation: A next-generation therapeutic paradigm for immune disorders[J]. Chinese Chemical Letters, ;2026, 37(10): 112135. doi: 10.1016/j.cclet.2025.112135 shu

Microneedle-mediated precision immunomodulation: A next-generation therapeutic paradigm for immune disorders

Chunxian Zhou ^{a, 1} ,
Mingyu Gong ^{a, 1} ,
Jubo Jian ^a ,
Huanhuan Pan ^a ,
Wanshan Hu ^a ,
Zeshi Jiang ^a ,
Chao Lu ^a ,
Guilan Quan ^a ,
Chuanbin Wu ^{a, b} ,
Xin Pan ^c ,
Junhuang Jiang ^{a, *,} ,
Tingting Peng ^{a, *,}

a.
State Key Laboratory of Bioactive Molecules and Drug ability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China
b.
Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Affiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan University, Jiangmen 529031, China
c.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

jhjiang@jnu.edu.cn

pengtt@jnu.edu.cn

Received Date: 27 August 2025
Revised Date: 17 November 2025
Accepted Date: 18 November 2025
Available Online: 19 November 2025

Figures(1)

Immune-mediated inflammatory diseases (IMIDs) are a class of chronic, relapsing disorders characterized by dysregulated immune activation and persistent inflammation. These conditions affect multiple organs, severely compromising patients' quality of life and increasing the global healthcare burden. Conventional treatments, such as glucocorticoids, immunosuppressants, and biologics, face limitations including low delivery efficiency, off-target effects, and poor patient adherence, whether administered topically or systemically. With the growing recognition of IMID pathogenesis as a multitargeted process, precision-based strategies and localized, patient-friendly drug delivery systems are increasingly needed. Microneedle (MN) technology has emerged as a promising transdermal and transmucosal platform for minimally invasive, site-specific therapeutic delivery in IMID treatment. By precisely targeting immune cells in the skin, oral mucosa, and eyes, MNs offer a novel approach to precision immunotherapy. This review explores recent advances in MN-based therapies for IMIDs, emphasizing their potential to transform the management of allergic conditions, autoimmune diseases, inflammatory skin disorders, infection-related chronic inflammation, oral disorders, and ocular disorders. Furthermore, the challenges hindering the clinical translation of MNs are discussed, along with perspectives on their future development. We anticipate that this review will provide innovative insights into precision immunotherapy for IMIDs.
- Microneedle,
- Immune disorders,
- Immunotherapy,
- Novel treatments,
- Prospects
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