Citation: Chu Wang, Zheng Xi, Rufang Zhao, Xiaohuan Sun, Jie Han, Rong Guo. Regulation of catalytic efficiency and enantioselectivity for supramolecular chiral polyaniline@Pt-Ni_x nanocomposites as nanozymes via tunable alloy composition[J]. Chinese Chemical Letters, ;2026, 37(9): 112125. doi: 10.1016/j.cclet.2025.112125 shu

Regulation of catalytic efficiency and enantioselectivity for supramolecular chiral polyaniline@Pt-Ni_x nanocomposites as nanozymes via tunable alloy composition

Chu Wang ^{a, b} ,
Zheng Xi ^{a, *,} ,
Rufang Zhao ^{c, *,} ,
Xiaohuan Sun ^a ,
Jie Han ^{a, *,} ,
Rong Guo ^a

a.
Jiangsu Provincial Key Laboratory of Green & Functional Materials and Environmental Chemistry, College of Chemistry and Materials, Yangzhou University, Yangzhou 225002, China
b.
School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, China
c.
Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, College of Chemistry and Chemical Engineering, Hubei Normal University, Huangshi 435002, China

xizheng@yzu.edu.cn

zhaorf@hbnu.edu.cn

hanjie@yzu.edu.cn

Received Date: 11 May 2025
Revised Date: 1 November 2025
Accepted Date: 16 November 2025
Available Online: 17 November 2025

Figures(4)

Nanozymes have demonstrated significant potential as robust enzyme-mimicking catalysts due to their high stability, low cost and easy preparation. However, achieving precise enantioselective control of nanozymes remains a significant challenge. In this study, the supramolecular chiral nanozymes were engineered by integrating supramolecular chiral polyaniline (P/M-PANI) scaffolds with platinum-nickel nanoparticles (Pt-Nix NPs). The resulting P/M-PANI@Pt-Nix nanozymes exhibited high catalytic activity toward the oxidation of 3,4-dihydroxy-S/R-phenylalanine (S/R-DOPA). Moreover, systematic modulation of the Pt/Ni atomic ratio in Pt-Nix NPs enabled precise regulation of interfacial interactions and chiral transfer effects, thereby optimizing enantioselectivity. Density functional theory (DFT) calculations further revealed that the distinct adsorption energies of DOPA and its oxidation products on Pt-Nix surfaces directly correlated with the observed catalytic efficiency trends. This work demonstrated that compositional tuning of catalytic centers is an effective strategy for manipulating both catalytic efficiency and enantioselectivity, providing valuable insights for the rational design of smart supramolecular chiral nanozymes.
- Supramolecular chirality,
- Nanozymes,
- Platinum-nickel nanoparticles,
- Polyaniline,
- Enantioselective catalysis
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沈阳化工大学材料科学与工程学院沈阳 110142

Regulation of catalytic efficiency and enantioselectivity for supramolecular chiral polyaniline@Pt-Nix nanocomposites as nanozymes via tunable alloy composition

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通讯作者: 陈斌, bchen63@163.com

Regulation of catalytic efficiency and enantioselectivity for supramolecular chiral polyaniline@Pt-Ni_x nanocomposites as nanozymes via tunable alloy composition