Citation: Lingling Lei, Lang Liu, Yi Zhu, Yanni Wang, Zhiyao Li, Yongmin Zhang, Fengrui Yang, Weidong Pan. Molecular probes for in vivo optical imaging of chemotherapy[J]. Chinese Chemical Letters, ;2026, 37(10): 112095. doi: 10.1016/j.cclet.2025.112095 shu

Molecular probes for in vivo optical imaging of chemotherapy

Lingling Lei ^a ,
Lang Liu ^a ,
Yi Zhu ^a ,
Yanni Wang ^a ,
Zhiyao Li ^a ,
Yongmin Zhang ^{c, *,} ,
Fengrui Yang ^{b, *,} ,
Weidong Pan ^{a, *,}

a.
Key laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China
b.
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
c.
Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire, UMR 8232, 4 Place Jussieu, Paris 75005, France

yongmin.zhang@upmc.fr

fengruiyang@hnu.edu.cn

wdpan@163.com

Received Date: 12 August 2025
Revised Date: 6 November 2025
Accepted Date: 7 November 2025
Available Online: 8 November 2025

Figures(7)

Elucidating drug mechanisms of action and evaluating therapeutic efficacy require advanced techniques for real-time, dynamic monitoring of drug-target interactions in living systems. Recent advances in optical molecular probes have yielded powerful tools to visualize drug targets, quantify pharmacodynamic profiles, and track drug metabolism. In this review, we first summarize the major categories of optical imaging targets for chemotherapy assessment, followed by a systematic discussion of optical probe design strategies tailored to these targets. We then comprehensively review probe applications in drug screening, target validation, efficacy assessment, adverse effect evaluation, biodistribution analysis, and metabolic pathway tracking. Finally, we discuss the prospects and challenges of molecular optical imaging in precision medicine and clinical applications, while proposing potential breakthroughs and future directions. This review serves as a valuable reference for advancing optical probe design and application in drug development.
- Molecular probes,
- Optical imaging,
- Drug screening,
- Target validation,
- Efficacy assessment,
- Adverse drug effects assessment
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沈阳化工大学材料科学与工程学院沈阳 110142