Citation: Sitian Zhang, Qiqiang Liang, Lei Su, Xinyu Zheng, Hanxiao Zeng, Weiguang Sun, Yuan Zhou, Yonghui Zhang, Zhengxi Hu. Acaualblides A–E, architecturally unprecedented macrolides from Acaulium album 429 with BCR-targeted immunosuppressive activity[J]. Chinese Chemical Letters, ;2026, 37(10): 112084. doi: 10.1016/j.cclet.2025.112084 shu

Acaualblides A–E, architecturally unprecedented macrolides from Acaulium album 429 with BCR-targeted immunosuppressive activity

Sitian Zhang ^{a, b, 1} ,
Qiqiang Liang ^{a, 1} ,
Lei Su ^{c, 1} ,
Xinyu Zheng ^a ,
Hanxiao Zeng ^a ,
Weiguang Sun ^{a, *,} ,
Yuan Zhou ^{a, *,} ,
Yonghui Zhang ^{a, *,} ,
Zhengxi Hu ^{a, d, e, *,}

a.
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
b.
Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan 430060, China
c.
NHC Key Laboratory of Human Disease Comparative Medicine, National Human Diseases Animal Model Resource Center, International Center for Technology and Innovation of Animal Model, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021, China
d.
Hubei Shizhen Laboratory, Wuhan 430061, China
e.
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311403, China

weiguang_sun@hust.edu.cn

yuan2273@163.com

zhangyh@mails.tjmu.edu.cn

hzx616@126.com

Received Date: 31 July 2025
Revised Date: 5 November 2025
Accepted Date: 6 November 2025
Available Online: 7 November 2025

Figures(6)

Acaualblides A–E (1–5), five architecturally unprecedented macrolides, were isolated from fungus Acaulium album 429 and comprehensively characterized. Their structures were elucidated by high-resolution electrospray ionization mass spectrometry (HRESIMS), extensive spectroscopic analyses, and single-crystal X-ray diffraction. Compounds 1–3 possess unusual fourteen-membered macrolide frameworks bearing pyridine or thiophene moieties. Compound 4 represents the first heterodimer featuring a macrolide unit covalently linked to an aflatoxin B₁ moiety through a C–C bond, while compound 5 is a unique homodimeric macrolide in which two identical units are connected by both a C-9/C-9′ carbon-carbon bond and a C-8/C-8′ thioether bridge. Plausible biosynthetic pathways for compounds 1–5 are proposed. Notably, compound 1 displayed significant immunosuppressive activity by inhibiting B-cell proliferation and activation through modulation of the B-cell receptor (BCR) signaling pathway.
- Acaulium album 429,
- Macrolides,
- Acaualblides A–E,
- Structure elucidation,
- Immunosuppressive activity
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沈阳化工大学材料科学与工程学院沈阳 110142