Citation: Xiang Huang, Na Wang, Junyan Liu, Wang Sun, Guorong Sun, Zhou Zhang, Shun Lu, Yang Wang. Flexible hydrogels with in-situ grown cobalt-based metal-organic frameworks for high-performance electrochemical detection of 2,4,6-trichloropshenol[J]. Chinese Chemical Letters, ;2026, 37(6): 112067. doi: 10.1016/j.cclet.2025.112067 shu

Flexible hydrogels with in-situ grown cobalt-based metal-organic frameworks for high-performance electrochemical detection of 2,4,6-trichloropshenol

Xiang Huang ^{a, 1} ,
Na Wang ^{c, 1} ,
Junyan Liu ^a ,
Wang Sun ^a ,
Guorong Sun ^a ,
Zhou Zhang ^a ,
Shun Lu ^{b, *,} ,
Yang Wang ^{a, *,}

a.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
b.
Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China
c.
Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China

lushun@cigit.ac.cn

wangyzu@126.com

Received Date: 9 April 2025
Revised Date: 18 September 2025
Accepted Date: 5 November 2025
Available Online: 5 November 2025

Figures(4)

Herein, a novel type of flexible network hydrogel was formed by cross-linking of chitosan (CS) and acrylamide (AM) monomer through non-covalent bond, and was named CS/PAM/hydrogel (CPH). Subsequent functional modification of the CPH was then undertaken through the implementation of in-situ green growth technology, and the cobalt organic framework (ZIF-67) was successfully grown on the hydrogel. Ultimately, the composite hydrogel CS/PAM/ZIF-67/hydrogel (CPZH) was prepared. Subsequently, an electrochemical sensor was developed by combining a composite hydrogel with a glassy carbon electrode, and it was demonstrated that this combination exhibited excellent performance, especially in the electrochemical detection of the target molecule 2,4.6-trichlorophenol. Excellent linear ranges (0.01–10 and 10–1000 μmol/L) and low detection limit (0.003 μmol/L) were achieved. The excellent electrochemical performance can be attributed to (ⅰ) 3D network structure of the hydrogel provides an effective mass transfer channel for the electrochemical reactants; (ⅱ) The MOF layer provides a wealth of catalytic active sites, resulting in electrochemical signal amplification of the CPZH composite, (ⅲ) The growth of ZIF-67 in the original location of the hydrogel network successfully solved the problem that traditional ZIF-67 particles are prone to agglomeration and exhibit weak bonding force with the substrate, which significantly improved the stability and electrochemical performance.
- 2,4,6-Trichlorophenol,
- Electrochemical sensor,
- Hydrogel,
- ZIF-67
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