Citation: Yuke Ji, Jia Liang, Xiangqing Hei, Lu Chen, Shudong Yu, Dong Fang, Hui Tan, Shaochong Zhang. Nanomaterial-based drug delivery systems for ocular diseases: A review[J]. Chinese Chemical Letters, ;2026, 37(9): 112062. doi: 10.1016/j.cclet.2025.112062 shu

Nanomaterial-based drug delivery systems for ocular diseases: A review

Yuke Ji ^{a, 1} ,
Jia Liang ^{b, 1} ,
Xiangqing Hei ^a ,
Lu Chen ^b ,
Shudong Yu ^c ,
Dong Fang ^{b, *,} ,
Hui Tan ^{d, *,} ,
Shaochong Zhang ^{a, b, *,}

a.
Shenzhen Eye Hospital, Jinan University, Shenzhen 518000, China
b.
Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen 518000, China
c.
School of Advanced Manufacturing, Sun Yat-sen University, Shenzhen 518000, China
d.
Center for Child Care and Mental Health, Shenzhen Children’s Hospital, Shenzhen 518000, China

dora.eye@hotmail.com

huitan@email.szu.edu.cn

Shaochongzhang@outlook.com

Received Date: 27 August 2025
Revised Date: 2 November 2025
Accepted Date: 3 November 2025
Available Online: 4 November 2025

Figures(2)

Ocular diseases are the main cause of vision loss and even blindness, with treatments including topical medications (such as eye drops), intravitreal injections, and surgery. However, the eye’s complex anatomical structure and physiological barriers significantly limit drug bioavailability, affecting therapeutic efficacy. Nanomaterials have shown promise in ophthalmic drug delivery due to their unique properties. Nanomaterials can effectively penetrate ocular barriers to enhance drug permeability and bioavailability. Their ocular penetration can be further optimized by regulating nanoparticle (NP) size and surface properties, thereby prolonging drug residence time on the ocular surface and reducing administration frequency. Additionally, as controlled-release carriers, they enable sustained drug release to extend therapeutic duration and improve treatment efficacy. In addition, some nanomaterials also possess biological activities such as antioxidant, antibacterial and anti-inflammatory, making them a promising therapeutic strategy. This review focuses on the advances in nanomaterials application for ocular diseases, summarizes the mechanisms underlying nanomaterial-based drug delivery, and discusses the current challenges and future research directions, with the aim of providing new insights into the clinical application and translation of nanomaterials in ophthalmology.
- Nanomaterials,
- Nanocarriers,
- Drug delivery,
- Ocular diseases,
- Ophthalmic treatment
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沈阳化工大学材料科学与工程学院沈阳 110142