Citation: Junfeng Huang, Hongxin Chen, Yan Liao, Xiaowen Zhang, Zengzhu Zhang, Xiaoyu Su, Zihong Xie, Biao Li, Baode Shen, Pengfei Yue. Metal-organic framework materials for encapsulation, release and delivery of essential oils: Engineering strategies and challenges[J]. Chinese Chemical Letters, ;2026, 37(3): 112049. doi: 10.1016/j.cclet.2025.112049 shu

Metal-organic framework materials for encapsulation, release and delivery of essential oils: Engineering strategies and challenges

Junfeng Huang ^{a, b} ,
Hongxin Chen ^b ,
Yan Liao ^b ,
Xiaowen Zhang ^b ,
Zengzhu Zhang ^c ,
Xiaoyu Su ^b ,
Zihong Xie ^b ,
Biao Li ^b ,
Baode Shen ^{a, b} ,
Pengfei Yue ^{a, b, *,}

a.
State Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China
b.
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
c.
Department of Pharmaceutics, 908th Hospital of Joint Logistics Support Force of PLA, Nanchang 330000, China

pengfeiyue@jxutcm.edu.cn

Received Date: 12 June 2025
Revised Date: 29 October 2025
Accepted Date: 31 October 2025
Available Online: 1 November 2025

Figures(2)

Essential oils (EOs) are widely present in aromatic plants and possess a wide range of significant pharmacological activities such as antibacterial, antioxidant and anti-tumor properties. They have broad application prospects in medical care, food, agriculture and other fields. However, their poor stability poses substantial challenges that significantly hinder their development and practical application. Metal-organic framework materials (MOFs), characterized by highly controllable structures, large specific surface areas, and stimuli-responsive release properties, have been extensively utilized in various fields such as drug delivery and food preservation. Due to their capacity to encapsulate and deliver EOs, MOFs have garnered considerable attention. In this review, we systematically summarize the structural features, types, and characteristics of MOFs, as well as the recent advancements in their application for controlled EO release. Furthermore, we focus on discussing engineering strategies aimed at enhancing the encapsulation, release, and delivery of EOs using MOFs. Finally, we briefly outline the existing challenges in the delivery of EOs using MOFs and present well-reasoned insights into prospective directions for future research.
- Essential oils,
- Metal-organic framework materials,
- Encapsulation,
- Release,
- Delivery,
- Engineering strategies
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