Citation: Yang Liu, Zi-Xi Wang, Fu-Gen Wu. Trapping extracellular vesicles from biofluids by hydrogels[J]. Chinese Chemical Letters, ;2026, 37(3): 112037. doi: 10.1016/j.cclet.2025.112037 shu

Trapping extracellular vesicles from biofluids by hydrogels

State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China

wufg@seu.edu.cn

Received Date: 1 October 2025
Revised Date: 26 October 2025
Accepted Date: 29 October 2025
Available Online: 29 October 2025

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1. [1]
  R. Shah, T. Patel, J.E. Freedman, N. Engl. J. Med. 379 (2018) 958–966. doi: 10.1056/nejmra1704286
2. [2]
  M. Mathieu, L. Martin-Jaular, G. Lavieu, et al., Nat. Cell Biol. 21 (2019) 9–17. doi: 10.1038/s41556-018-0250-9
3. [3]
  A. Moller, R.J. Lobb, Nat. Rev. Cancer 20 (2020) 697–709. doi: 10.1038/s41568-020-00299-w
4. [4]
  P. Li, M. Kaslan, S. Lee, et al., Theranostics 7 (2017) 789–804. doi: 10.7150/thno.18133
5. [5]
  J. Kim, M. Kang, G. Han, et al., Nat. Nanotechnol. 20 (2025) 1678–1687. doi: 10.1038/s41565-025-02011-1
6. [6]
  S. Hu, R. Hao, Z. Yu, et al., Chin. Chem. Lett. 35 (2024) 108534. doi: 10.1016/j.cclet.2023.108534
7. [7]
  X. Zhao, X. Liu, T. Chen, et al., ACS Nano 19 (2025) 8948–8965. doi: 10.1021/acsnano.4c16988
8. [8]
  F. Zhu, Y. Ji, J. Deng, et al., Chin. Chem. Lett. 33 (2022) 2893–2900. doi: 10.1016/j.cclet.2021.09.058
9. [9]
  A. Görgens, G. Corso, D.W. Hagey, et al., J. Extracell. Vesicles 11 (2022) e12238. doi: 10.1002/jev2.12238
10. [10]
  V. Sakthivelu, A. Schmitt, F. Odenthal, et al., Nature 646 (2025) 1243–1253. doi: 10.1038/s41586-025-09434-9
11. [11]
  N. Lafuente-Gómez, S. Kang, D.J. Mooney, Nat. Nanotechnol. 20 (2025) 1186–1198. doi: 10.1038/s41565-025-02008-w
12. [12]
  J. Su, Y. Song, Z. Zhu, et al., Sig. Transduct. Target. Ther. 9 (2024) 196. doi: 10.1038/s41392-024-01888-z
1. [1]
  Gaojian Yang , Zhiyang Li , Rabia Usman , Zhu Chen , Yuan Liu , Song Li , Hui Chen , Yan Deng , Yile Fang , Nongyue He . DNA walker induced "signal on" fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer. Chinese Chemical Letters, 2025, 36(2): 109930-. doi: 10.1016/j.cclet.2024.109930
2. [2]
  Hui Li , Zhenjie Zhao , Bingqiang Ji , Jun Ma , Xuwu Zhang , Jingzhao Chen , Zhangran Ye , Zuankai Wang , Liqiang Zhang , Jianyu Huang , Yingdan Liu . Electric tweezer for single microscopic particle trapping. Chinese Chemical Letters, 2026, 37(3): 110655-. doi: 10.1016/j.cclet.2024.110655
3. [3]
  Binhan Zhao , Zheng Li , Lan Zheng , Zhichao Ye , Yuyang Yuan , Shanshan Zhang , Bo Liang , Tianyu Li . Recent progress in the biomedical application of PEDOT:PSS hydrogels. Chinese Chemical Letters, 2024, 35(10): 109810-. doi: 10.1016/j.cclet.2024.109810
4. [4]
  Xinyi Wang , Iek Man Lei , Bei Li , Yunlu Dai . Progress in extracellular vesicle@STING towards immune regulation. Chinese Chemical Letters, 2026, 37(2): 110990-. doi: 10.1016/j.cclet.2025.110990
5. [5]
  Junmei FAN , Wei LIU , Ruitao ZHU , Chenxi QIN , Xiaoling LEI , Haotian WANG , Jiao WANG , Hongfei HAN . High sensitivity detection of baicalein by N, S co-doped carbon dots and their application in biofluids. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2009-2020. doi: 10.11862/CJIC.20240120
6. [6]
  Zikang Hu , Hengjie Zhang , Zhengqiu Li , Tianbao Zhao , Zhipeng Gu , Qijuan Yuan , Baoshu Chen . Multifunctional photothermal hydrogels: Design principles, various functions, and promising biological applications. Chinese Chemical Letters, 2024, 35(10): 109527-. doi: 10.1016/j.cclet.2024.109527
7. [7]
  Ruijun Song , Huixu Xie , Guiting Liu . Advances of MXene-based hydrogels for chronic wound healing. Chinese Chemical Letters, 2025, 36(7): 110442-. doi: 10.1016/j.cclet.2024.110442
8. [8]
  Hao Sun , Shengke Li , Qian Liu , Minzan Zuo , Xueqi Tian , Kaiya Wang , Xiao-Yu Hu . Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy. Chinese Chemical Letters, 2025, 36(3): 109999-. doi: 10.1016/j.cclet.2024.109999
9. [9]
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10. [10]
  Min Zhang , Ye Chen , Yanan Li , Yifan Zhao , Bai Lv , Jie Cao , Bing Yu , Hailin Cong . Manipulating extracellular matrix to enhance intratumor drug delivery for nanomaterial-based photothermal therapy. Chinese Chemical Letters, 2025, 36(12): 111588-. doi: 10.1016/j.cclet.2025.111588
11. [11]
  Lijun Liao , Yuhao Wang , Yanbo Li , Yingchun Chen , Ruting Yuan , Bo Wang , Tiancheng Zhuang , Guangquan Zhao , Wei Zhou . Synergy of electron-trapping centers and solid adsorption toward 100% suppression of toxic byproduct N₂O in photocatalytic NO reduction. Chinese Chemical Letters, 2026, 37(3): 111398-. doi: 10.1016/j.cclet.2025.111398
12. [12]
  Shaoqiang Wen , Lang Zhang , Zhan Huang , Meng Chen , Yuzhi Xu , Xing Huang , Zhou Zhang , Xiaoyong Zou , Zong Dai , Si-Yang Liu . Aptamer&MOF-functionalized multichannel paper chip for point-of-care testing of small extracellular vesicle membrane protein profile. Chinese Chemical Letters, 2026, 37(2): 111333-. doi: 10.1016/j.cclet.2025.111333
13. [13]
  Zhe-Han Yang , Jie Yin , Lei Xin , Yuanfang Li , Yijie Huang , Ruo Yuan , Ying Zhuo . Research advancement of DNA-based intelligent hydrogels: Manufacture, characteristics, application of disease diagnosis and treatment. Chinese Chemical Letters, 2024, 35(10): 109558-. doi: 10.1016/j.cclet.2024.109558
14. [14]
  Yue Sun , Yingnan Zhu , Jiahang Si , Ruikang Zhang , Yalan Ji , Jinjie Fan , Yuze Dong . Glucose-activated nanozyme hydrogels for microenvironment modulation via cascade reaction in diabetic wound. Chinese Chemical Letters, 2025, 36(4): 110012-. doi: 10.1016/j.cclet.2024.110012
15. [15]
  Mengchen Liu , Yufei Zhang , Yi Xiao , Yang Wei , Meichen Bi , Huaide Jiang , Yan Yu , Shenghong Zhong . High stretchability and toughness of liquid metal reinforced conductive biocompatible hydrogels for flexible strain sensors. Chinese Journal of Structural Chemistry, 2025, 44(3): 100518-100518. doi: 10.1016/j.cjsc.2025.100518
16. [16]
  Jielin Wang , Han Ye , Bozhuang Zhou , Zhen Pan , Yucai Li , Zhenyuan Wei , Bin Chai , Yizhou Gao , Xiaojian Ye , Jiangming Yu . Biomimetic nanofibrillar/hyaluronic acid hydrogels remodel the neuromodulatory microenvironment for enhanced bone regeneration. Chinese Chemical Letters, 2025, 36(5): 110133-. doi: 10.1016/j.cclet.2024.110133
17. [17]
  Chaojian Xu , Juxin Yin , Sihong Wang , Yue Pan , Qianhe Zhang , Ningkang Xie , Shuo Yang , Shaowu Lv . Aerobic radical polymerization of hydrogels triggered by acetylacetone-transition metal self-initiation. Chinese Chemical Letters, 2025, 36(7): 111075-. doi: 10.1016/j.cclet.2025.111075
18. [18]
  Yuanmao Fu , Ziang Wang , Kefan Wu , Feiyang Li , Xian Zhang , Hongyuan Cui , Xiaolin Wang , Hui Guo , Yuezhong Meng . Bio-inspired multifunctional hydrogels with adhesive, anti-bacterial, anti-icing and sensing properties. Chinese Chemical Letters, 2025, 36(7): 110479-. doi: 10.1016/j.cclet.2024.110479
19. [19]
  Xueling Yu , Lixing Fu , Tong Wang , Zhixin Liu , Na Niu , Ligang Chen . Multivariate chemical analysis: From sensors to sensor arrays. Chinese Chemical Letters, 2024, 35(7): 109167-. doi: 10.1016/j.cclet.2023.109167
20. [20]
  Jialiang XU , Jiabin CUI . Recent biological applications of corroles: From diagnosis to therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2303-2317. doi: 10.11862/CJIC.20240245

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