Citation: Mingjun Yang, Zhongyong Xu, Lei Wang, Mingle Li, Xiaoqiang Chen, Bin Liu, Xiaojun Peng. Real-time analysis of pyriproxyfen using FA1-targeting albumin-based supramolecular probe with enhanced anti-interference performance[J]. Chinese Chemical Letters, ;2026, 37(9): 112028. doi: 10.1016/j.cclet.2025.112028 shu

Real-time analysis of pyriproxyfen using FA1-targeting albumin-based supramolecular probe with enhanced anti-interference performance

College of Material Science and Engineering, State Key Laboratory of Fine Chemicals, Shenzhen University, Shenzhen 518060, China

xzy@szu.edu.cn

bliu@szu.edu.cn

Received Date: 15 July 2025
Revised Date: 23 October 2025
Accepted Date: 27 October 2025
Available Online: 28 October 2025

Figures(5)

Given the widespread use of pyriproxyfen (PPF) in public health and agricultural pest management, accurate residue monitoring is critical to ensuring food safety, preserving ecological equilibrium, and protecting human health. While fluorescent sensing techniques represent promising paradigm for PPF detection, existing probes often lack rapid response and high specificity. To address this issue, we present the development of a novel FA1-targeting albumin-based supramolecular probe (DOCD@ALB) for the ratiometric detection of PPF. The strategy design minimizes competitive interference from DS1-binding compounds (e.g., epicatechin), thereby significantly improving its detection accuracy and specificity. When integrated with a smartphone-assisted portable sensing device, the DOCD@ALB system enables on-site PPF quantification in tea matrices, demonstrating its clear translational potential. These findings highlight the pivotal role of binding site selection in modulating the sensing performance of the supramolecular probe system, offering a robust analytical tool with implications for food safety surveillance and environmental protection.
- Pyriproxyfen,
- Anti-interference,
- Albumin,
- FA1-targeting,
- Supramolecular probes
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