Citation: Xiaojia Xue, Xiangyi Jiang, Jiaojiao Dai, Xinyong Liu, Eline Pellaers, Debyser Zeger, Peng Zhan. Deciphering the HIV reservoir: From epigenetic regulators to RNA-mediated regulation[J]. Chinese Chemical Letters, ;2026, 37(6): 112019. doi: 10.1016/j.cclet.2025.112019 shu

Deciphering the HIV reservoir: From epigenetic regulators to RNA-mediated regulation

Xiaojia Xue ^{a, 1} ,
Xiangyi Jiang ^{a, 1} ,
Jiaojiao Dai ^a ,
Xinyong Liu ^{a, *,} ,
Eline Pellaers ^b ,
Debyser Zeger ^{b, *,} ,
Peng Zhan ^{a, *,}

a.
Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China
b.
Targeted Drug Discovery and Gene Therapy (ADVANTAGE), KU-Leuven, Herestraat 49, 3000-Leuven, Flanders, Belgium

xinyongl@sdu.edu.cn

zeger.debyser@kuleuven.be

zhanpeng1982@sdu.edu.cn

Received Date: 20 August 2025
Revised Date: 21 October 2025
Accepted Date: 22 October 2025
Available Online: 24 October 2025

1. [1]
  S. Wang, D. Shen, L. Zhao, et al., Chin. Chem. Lett. 31 (2020) 418–422. doi: 10.1016/j.cclet.2019.08.029
2. [2]
  E. Pellaers, J. Janssens, L. Wils, et al., Nat. Commun. 16 (2025) 4226. doi: 10.1038/s41467-025-59398-7
3. [3]
  T.Y. Luk, L.Y. Yim, R. Zhou, et al., Proc. Natl. Acad. Sci. U. S. A. 122 (2025) e2418467122. doi: 10.1073/pnas.2418467122
4. [4]
  X. Wang, Y. Xue, L. Li, et al., Nat. Commun. 16 (2025) 4529. doi: 10.1007/s11426-025-2842-9
5. [5]
  R. Li, K. Daneshvar, X. Ji, et al., Sci. Adv. 11 (2025) eadu8014. doi: 10.1126/sciadv.adu8014
6. [6]
  K. Sugata, A. Rahman, K. Niimura, et al., Nat. Microbiol. 10 (2025) 1447–1462. doi: 10.1038/s41564-025-02006-7
7. [7]
  J.P. Cooney, A. Hirons, N. Jansz, et al., Cell 188 (2025) 4896–4912.e19. doi: 10.1016/j.cell.2025.06.023
1. [1]
  Shu-Yi Gu , Tian Feng , Fang-Yin Gang , Si-Yu Yu , Wan Chan , Zhao-Cheng Ma , Yao-Hua Gu , Bi-Feng Yuan . Persistent organic pollutant perfluorooctanoic acid induces alterations in epigenetic modifications of DNA and RNA. Chinese Chemical Letters, 2025, 36(12): 110957-. doi: 10.1016/j.cclet.2025.110957
2. [2]
  Yan Liu , Yang Wang , Jiayi Zhu , Xuxian Su , Xudong Lin , Liang Xu , Xiwen Xing . Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells. Chinese Chemical Letters, 2024, 35(9): 109427-. doi: 10.1016/j.cclet.2023.109427
3. [3]
  Keqiang Shi , Xiujuan Hong , Dongyan Xu , Tao Pan , Huiwen Wang , Hongru Feng , Cheng Guo , Yuanjiang Pan . Analysis of RNA modifications in peripheral white blood cells from breast cancer patients by mass spectrometry. Chinese Chemical Letters, 2025, 36(3): 110079-. doi: 10.1016/j.cclet.2024.110079
4. [4]
  Lin Yang , Xia Liu , Bohan Li , Zhuo Liu , Yani Li , Canzhi Shi , Yan Xu . Emission regulation in 0D hybrid copper halides via structural transformation: From defect to non-defect states for information encryption and storage. Chinese Chemical Letters, 2026, 37(5): 110858-. doi: 10.1016/j.cclet.2025.110858
5. [5]
  Yang Chu , Xiao-Hui Li , Zhong Zhang , Na Xu , Dan-Feng He , Xiu-Li Wang . Size regulation from single-crystal to nanoscale of a polyoxometalate-based Cu-triazole complex for catalytic oxidation reaction of phenols. Chinese Chemical Letters, 2026, 37(6): 111012-. doi: 10.1016/j.cclet.2025.111012
6. [6]
  Ali Dai , Zhiguo Zheng , Liusheng Duan , Jian Wu , Weiming Tan . Small molecule chemical scaffolds in plant growth regulators for the development of agrochemicals. Chinese Chemical Letters, 2025, 36(4): 110462-. doi: 10.1016/j.cclet.2024.110462
7. [7]
  Xuanyang Jin , Xincheng Guo , Siyang Dong , Shilan Li , Shengdong Jin , Peng Xia , Shengjun Lu , Yufei Zhang , Haosen Fan . Synergistic regulation of polysulfides shuttle effect and lithium dendrites from cobalt-molybdenum bimetallic carbides (Co-Mo-C) heterostructure for robust Li-S batteries. Chinese Chemical Letters, 2025, 36(7): 110604-. doi: 10.1016/j.cclet.2024.110604
8. [8]
  Huiping Shi , Shaojun Peng , Minghui Yang , Yuanyu Huang . Engineering circular RNA with Tetrahymena group Ⅰ intron ribozyme. Chinese Chemical Letters, 2025, 36(9): 111160-. doi: 10.1016/j.cclet.2025.111160
9. [9]
  Kai Tang , Guochao Wei , Peng Zhan . Breaking the impossible: The evolutionary journey of lenacapavir, a long-acting anti-HIV drug. Chinese Chemical Letters, 2025, 36(7): 110500-. doi: 10.1016/j.cclet.2024.110500
10. [10]
  Tian Feng , Shu-Yi Gu , Lu-Fei Shi , Yao-Hua Gu , Bi-Feng Yuan . Mass spectrometry analysis reveals changes in patterns and correlations of nucleic acid epigenetic modifications in mouse tissues exposed to polystyrene microplastics. Chinese Chemical Letters, 2026, 37(3): 111546-. doi: 10.1016/j.cclet.2025.111546
11. [11]
  Mengjun Zhao , Yuhao Guo , Na Li , Tingjiang Yan . Deciphering the structural evolution and real active ingredients of iron oxides in photocatalytic CO2 hydrogenation. Chinese Journal of Structural Chemistry, 2024, 43(8): 100348-100348. doi: 10.1016/j.cjsc.2024.100348
12. [12]
  Wenzheng Chen , Weiyun Chen , Bin Chen , Mingbao Feng . Deciphering the electron-shuttling role of iron(Ⅲ) porphyrin in modulating the reductive UV/S(Ⅳ) system into the oxidative strategy for micropollutant abatement. Chinese Chemical Letters, 2025, 36(10): 110743-. doi: 10.1016/j.cclet.2024.110743
13. [13]
  Qianqing Xu , Qu Jiang , Haoyue Zhang , Fang Song . Deciphering the active species of anodically activated carbon-based electrocatalysts for oxygen evolution reaction. Chinese Chemical Letters, 2025, 36(11): 111417-. doi: 10.1016/j.cclet.2025.111417
14. [14]
  Weixin Zhao , Shuocheng Shao , Hao Ma , Jianyuan Zhen , Shufei He , Chuandong Wu , Liangliang Wei . Deciphering the potential mechanisms and influencing factors of the effects of micro(nano)plastics on microbe in sludge anaerobic digestion system. Chinese Chemical Letters, 2025, 36(11): 110846-. doi: 10.1016/j.cclet.2025.110846
15. [15]
  Yue Jin , Kun Dai , Lu Song , Xiaolei Zuo , Guangbao Yao , Min Li . Valence-programmed RNA origami for potent innate immune activation. Chinese Chemical Letters, 2025, 36(10): 110744-. doi: 10.1016/j.cclet.2024.110744
16. [16]
  Xiaowen Cao , Yuheng Zhu , Siyue Fan , Feng Chen , Yongxi Zhao . Accurate counting of RNA in tissues with highly denoising amplified imaging. Chinese Chemical Letters, 2025, 36(12): 111091-. doi: 10.1016/j.cclet.2025.111091
17. [17]
  Bairu Meng , Zongji Zhuo , Han Yu , Sining Tao , Zixuan Chen , Erik De Clercq , Christophe Pannecouque , Dongwei Kang , Peng Zhan , Xinyong Liu . Design, synthesis, and biological evaluation of benzo[4,5]thieno[2,3-d]pyrimidine derivatives as novel HIV-1 NNRTIs. Chinese Chemical Letters, 2024, 35(6): 108827-. doi: 10.1016/j.cclet.2023.108827
18. [18]
  Yongjian Jiang , Feng Cheng , Jun Zhou , Lei Zhan , Chunmei Li , Chengzhi Huang . Regulation of cancer cell apoptosis with DNA nanocalculator. Chinese Chemical Letters, 2026, 37(1): 110071-. doi: 10.1016/j.cclet.2024.110071
19. [19]
  Jun Xiong , Ke-Ke Chen , Neng-Bin Xie , Wei Chen , Wen-Xuan Shao , Tong-Tong Ji , Si-Yu Yu , Yu-Qi Feng , Bi-Feng Yuan . Demethylase-assisted site-specific detection of N¹-methyladenosine in RNA. Chinese Chemical Letters, 2024, 35(5): 108953-. doi: 10.1016/j.cclet.2023.108953
20. [20]
  Tian Feng , Yun-Ling Gao , Di Hu , Ke-Yu Yuan , Shu-Yi Gu , Yao-Hua Gu , Si-Yu Yu , Jun Xiong , Yu-Qi Feng , Jie Wang , Bi-Feng Yuan . Chronic sleep deprivation induces alterations in DNA and RNA modifications by liquid chromatography-mass spectrometry analysis. Chinese Chemical Letters, 2024, 35(8): 109259-. doi: 10.1016/j.cclet.2023.109259

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(15)
HTML views(2)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return