Citation: Yuhuan Wu, Hoiian Ieong, Wenhao Wang, Chuanbin Wu, Anqi Lu, Xin Pan, Zhengwei Huang. Polymer modification effects in nanocarrier-loaded dissolving microneedles: Implications for transdermal drug delivery[J]. Chinese Chemical Letters, ;2026, 37(3): 111944. doi: 10.1016/j.cclet.2025.111944 shu

Polymer modification effects in nanocarrier-loaded dissolving microneedles: Implications for transdermal drug delivery

Yuhuan Wu ^a ,
Hoiian Ieong ^a ,
Wenhao Wang ^a ,
Chuanbin Wu ^b ,
Anqi Lu ^{a, *,} ,
Xin Pan ^{a, *,} ,
Zhengwei Huang ^{b, *,}

a.
School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou 510006, China
b.
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 511436, China

luanq3@mail.sysu.edu.cn

panxin2@mail.sysu.edu.cn

huangzhengw@jnu.edu.cn

Received Date: 21 July 2025
Revised Date: 9 October 2025
Accepted Date: 10 October 2025
Available Online: 11 October 2025

Figures(3)

Polymer surface modification constitutes a pivotal strategy for enhancing the efficacy of nanomedicine delivery, where intentional modifications (e.g., PEGylation, hyaluronic acid coating) are designed to optimize nanocarrier performance. However, conventional approaches remain constrained by the impermeable stratum corneum in transdermal applications. Dissolving microneedles (DMNs) circumvent this barrier by creating transient microchannels, thereby offering an innovative route for cutaneous nanocarriers administration. Nevertheless, the DMN polymeric matrix may unintentionally alter the physicochemical attributes of loaded nanocarriers via non-covalent interactions, giving rise to a distinct “polymer modification effect” (PME) that differs from purposeful surface engineering. Such unintended interfacial phenomena can modulate nanocarrier characteristics and, consequently, dictate their in vivo fate, including release kinetics, biodistribution, clearance, cellular uptake, and other interactions with the biological system. Herein, we review documented cases of DMN polymer-nanocarrier modifications, elucidate the underlying mechanisms and implications of PME, and propose rational strategies for its precise regulation. This conceptual framework is expected to guide the rational design of next-generation nanocarrier-loaded DMN delivery systems.
- Dissolving microneedle,
- Polymer modification effect,
- Interaction,
- Polymer,
- In vivo fate
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沈阳化工大学材料科学与工程学院沈阳 110142