Citation: Fuyang Yue, Fei Yuan, Kun Li, Xun Luo, Hongjian Song, Yuxiu Liu, Qingmin Wang. Synthesis of antifungal gem–difluoroallylsilane compounds via radical transfer strategy[J]. Chinese Chemical Letters, ;2026, 37(7): 111940. doi: 10.1016/j.cclet.2025.111940 shu

Synthesis of antifungal gem–difluoroallylsilane compounds via radical transfer strategy

State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China

wangqm@nankai.edu.cn

Received Date: 21 June 2025
Revised Date: 24 September 2025
Accepted Date: 9 October 2025
Available Online: 10 October 2025

Figures(5)

gem–Difluorovinyl compounds and silicon-containing compounds are valuable structural units in organic and medicinal chemistry. However, they are mostly found separately in most compounds. In this study, we present a photocatalytic approach for the synthesis of gem–difluorovinylsilanes, using readily accessible silylboronic pinacol esters as reagents. Through a radical transfer strategy, this method overcomes the limitation of their high oxidation potential. Biological assays further confirmed that several target compounds exhibited moderate to potent antifungal activity against plant pathogens, including Botrytis cinerea, Setosphaeria turcica and Rhizoctonia solani.
- Antifunga,
- Photoredox,
- Difluoroallylsilane,
- Radicals,
- Trifluoroolefins
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