Citation: Ao Zhou, Mostafa M.K. Amer, Qin Yin. Recent advances on asymmetric reduction via dynamic kinetic resolution[J]. Chinese Chemical Letters, ;2026, 37(5): 111929. doi: 10.1016/j.cclet.2025.111929 shu

Recent advances on asymmetric reduction via dynamic kinetic resolution

Ao Zhou ^a ,
Mostafa M.K. Amer ^{b, c} ,
Qin Yin ^{a, b, *,}

a.
Faculty of Pharmaceutical Sciences, Shenzhen University of Advanced Technology, Shenzhen 518107, China
b.
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China

yinqin@suat-sz.edu.cn

qin.yin@siat.ac.cn

Received Date: 13 June 2025
Revised Date: 10 September 2025
Accepted Date: 29 September 2025
Available Online: 30 September 2025

Figures(67)

Asymmetric reduction of unsaturated compounds via dynamic kinetic resolution (DKR) has significantly enhanced the efficiency and selectivity of synthesizing enantiomerically pure compounds from racemic substrates. This approach combines the simultaneous racemization of substrates with enantioselective reduction, enabling quantitative yields and high enantiomeric excess. In the past several years, remarkable advances in this field have been achieved, ranging from the development of innovative catalytic systems, novel synthetic strategies, expansion of substrate scope, deeper mechanistic understanding, and their applications. These advancements offer alternative and efficient methods in the asymmetric synthesis of chiral molecules bearing multiple consecutive stereogenic centers, particularly beneficial for the synthesis of natural products or chiral intermediates in pharmaceuticals and fine chemicals. In this review, we summarize the recent advances during the last several years according to the substrate types in this powerful and productive field, with an emphasis on the development of new catalytic systems and the insight into the DKR process.
- Dynamic kinetic resolution,
- Asymmetric reduction,
- Asymmetric hydrogenation,
- Transfer hydrogenation,
- Drug synthesis
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沈阳化工大学材料科学与工程学院沈阳 110142