Citation: Xinwei Hu, Yong Zeng, Jiongdong Ma, Han Diao, Fei-Xiao Chen, Mu Chen, Shou-Kun Zhang, Chengzhi Jin, Shao-Fei Ni, Zhixiong Ruan. Electrochemical selenylation of tyrosine oligopeptides to benzo[b]furan-functionalized peptides[J]. Chinese Chemical Letters, ;2026, 37(3): 111928. doi: 10.1016/j.cclet.2025.111928 shu

Electrochemical selenylation of tyrosine oligopeptides to benzo[b]furan-functionalized peptides

Xinwei Hu ^{a, 1} ,
Yong Zeng ^{a, 1} ,
Jiongdong Ma ^{a, 1} ,
Han Diao ^{a, 1} ,
Fei-Xiao Chen ^b ,
Mu Chen ^a ,
Shou-Kun Zhang ^a ,
Chengzhi Jin ^{a, *,} ,
Shao-Fei Ni ^{b, *,} ,
Zhixiong Ruan ^{a, *,}

a.
Department of Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou 511436, China
b.
Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong, Shantou University, Shantou 515063, China

chengzhijin@gzhmu.edu.cn

sfni@stu.edu.cn

zruan@gzhmu.edu.cn

Received Date: 2 September 2025
Revised Date: 24 September 2025
Accepted Date: 29 September 2025
Available Online: 1 October 2025

Figures(7)

Benzo[b]furans are significant scaffolds in drug molecules and are prevalent structural components in natural products. Chemically encoded non-natural peptidomimetics have a substantial impact on pharmaceuticals by offering enhanced stability, improved cell permeability, and resistance to enzymatic degradation. Consequently, a strategy for the sustainable assembly of benzo[b]furan/benzopyran-functionalized peptides through the electrochemical late-stage modification of alkyne-modified tyrosine oligopeptides is proposed. This approach facilitates the multifunctional integration of non-native tyrosine-derived substrates, as well as their subsequent functionalization. Notably, the resulting peptides exhibit favorable properties regarding biocompatibility and cellular uptake.
- Electrochemical,
- Tyrosine oligopeptides,
- Selenylation,
- Benzo[b]furan,
- Biocompatibility
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