Citation: Chao He, Wanpin Yu, Qingyuan Zhao, Huina Liu, Yu Wang, Yue Xiong, Yuqing Zeng, Jing Zhao, Zhi Ping Xu, Lingxiao Zhang. Exosomes shape inflammatory tumor microenvironment[J]. Chinese Chemical Letters, ;2026, 37(9): 111900. doi: 10.1016/j.cclet.2025.111900 shu

Exosomes shape inflammatory tumor microenvironment

Chao He ^{a, b, 1} ,
Wanpin Yu ^{a, 1} ,
Qingyuan Zhao ^{a, 1} ,
Huina Liu ^a ,
Yu Wang ^b ,
Yue Xiong ^c ,
Yuqing Zeng ^c ,
Jing Zhao ^b ,
Zhi Ping Xu ^{a, b, c, *,} ,
Lingxiao Zhang ^{a, b, d, *,}

a.
School of Medicine, Hangzhou City University, Hangzhou 310015, China
b.
Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518107, China
c.
School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China
d.
Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C 8000, Denmark

gordonxu@szbl.ac.cn

zhanglx@inano.au.dk

Received Date: 27 May 2025
Revised Date: 22 September 2025
Accepted Date: 24 September 2025
Available Online: 25 September 2025

Figures(4)

The pervasive inflammatory response orchestrates every stage of tumor initiation and progression, not only serving as a catalyst for tumorigenesis but also as a nurturing environment for malignant growth. Within this intricate microenvironment teeming with cancer cells, immune cells, and stromal cells, a continuous exchange of inflammatory signals mediated by exosomes, small membrane-bound vesicles guide the development of the proinflammatory tumor microenvironment (TME). In this review, we delve into the intricate dialogue mechanisms among tumor cells, resident immune cells and stromal cells, scrutinizing the roles of exosomes derived from both tumor cells and other resident cells in shaping the inflammatory milieu. Anti-tumor therapies harnessing the diverse compositions and effects of exosomes have unveiled novel strategies for combating tumor malignancy.
- Inflammatory tumor microenvironment,
- Exosomes,
- Cellular communication,
- Education and crosstalk,
- Pro-tumor and anti-tumor
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