Citation: Dengke Ma, Youai Qiu. Electrochemical strategies for advancing enantioselective enamine catalysis[J]. Chinese Chemical Letters, ;2026, 37(4): 111892. doi: 10.1016/j.cclet.2025.111892 shu

Electrochemical strategies for advancing enantioselective enamine catalysis

Dengke Ma ^{a, *,} ,
Youai Qiu ^{b, *,}

a.
School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
b.
State Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, College of Chemistry, Nankai University, Tianjin 300071, China

madk@ccmu.edu.cn

qiuyouai@nankai.edu.cn

Received Date: 25 June 2025
Revised Date: 3 September 2025
Accepted Date: 24 September 2025
Available Online: 24 September 2025

Figures(19)

Enantioselective enamine catalysis has enriched asymmetric synthesis by enabling precise stereochemical control. While classically thermal/photochemical strategies have expanded reaction diversity, electrochemical enantiocontrol remains underexplored despite its potential for tunable redox manipulation. This review systematically evaluates electrochemical enantioselective enamine catalysis through polar/radical mediated chemical bond formation pathways, aiming to delineate current mechanistic paradigms and highlight electrochemistry's unique role on asymmetric enamine catalysis beyond thermodynamic and photochemical conditions. Future efforts including developing enhanced compatibility of chiral catalysts and intermediates with electrochemical systems, as well as exploiting transformative techniques for mechanistic elucidation could be promising to unlock more novel transformations and stereoselectivity models.
- Electrochemistry,
- Asymmetric catalysis and synthesis,
- Enamine catalysis,
- Stereocontrol,
- Radical chemistry
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