Citation: Kaihang Sheng, Yanshuai Wang, Siyuan Yin, Xiuling Li, Xinya Zhang, Xiaowei Li, Dechao Niu. Gold nanorods-loaded quaternized mesoporous silica nanospheres with synergistic adhesion and photothermal antibacterial mechanism for diabetic wound healing[J]. Chinese Chemical Letters, ;2026, 37(8): 111852. doi: 10.1016/j.cclet.2025.111852 shu

Gold nanorods-loaded quaternized mesoporous silica nanospheres with synergistic adhesion and photothermal antibacterial mechanism for diabetic wound healing

Kaihang Sheng ^{a, 1} ,
Yanshuai Wang ^{a, 1} ,
Siyuan Yin ^a ,
Xiuling Li ^b ,
Xinya Zhang ^a ,
Xiaowei Li ^{b, *,} ,
Dechao Niu ^{a, *,}

a.
Low Dimensional Materials Chemistry Laboratory, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
b.
School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China

weis.lee@163.com

dcniu@ecust.edu.cn

Received Date: 24 June 2025
Revised Date: 16 September 2025
Accepted Date: 17 September 2025
Available Online: 17 September 2025

Figures(5)

Synergistic strategy of cationic antibacterial and nanoparticle mediated photothermal conversion provides new opportunities to address bacterial infections. However, the conventional post-modification and lack of precise structural regulation, leads to the complexity of operation and unsatisfying synergistic effect on antibacterial performance. To address these challenges, herein, a novel "selective extraction and domain-restricted growth" approach has been proposed to successfully synthesize quaternized mesoporous silica nanosphere (QMSN) encapsulating gold nanorods (GNRs) inside the pore channel (GNRs@QMSN) for the treatment of bacterial infected diabetic wound. The strategy exhibits extensive convenience, enabling the ultra-uniform microporous core-mesoporous shell structure with positive charges. Most importantly, GNRs@QMSN demonstrated an excellent photothermal conversion efficiency up to 63.73%, due to the unique pore-domain-limited effect. Under the synergistic effect of positive charge surface for enhanced bacteria adhesion, intrinsic antibacterial quaternization and GNRs-mediated photothermal conversion, GNRs@QMSN exhibited excellent antibacterial and antibiofilm performance in vitro. The feasibility of GNRs@QMSN was further validated in a mouse diabetic wound infection model. This novel QMSN encapsulating GNRs is expected to be a promising paradigm for bacterial infected wound healing.
- Antibacterial,
- Mesoporous silica,
- Quaternization,
- Adhesion,
- Photothermal
1. [1]
  H. Li, J.A. Jiang, X.Y. Lv, et al., Small 20 (2024) 2402723. doi: 10.1002/smll.202402723
2. [2]
  Y. Xu, J.A. Jiang, X.Y. Lv, et al., Chem. Eng. J. 479 (2024) 147645. doi: 10.1016/j.cej.2023.147645
3. [3]
  X.Y. Ren, C.Y. Yang, L. Zhang, et al., Nanoscale 11 (2019) 11830–11838. doi: 10.1039/c9nr03612a
4. [4]
  Y.L. You, Y.X. Zhu, J.J. Jiang, et al., J. Am. Chem. Soc. 145 (2023) 13249–13260. doi: 10.1021/jacs.3c02669
5. [5]
  M. Ge, Z.S. Ruan, Y.X. Zhu, et al., Sci. Adv. 10 (2024) eadp3976. doi: 10.1126/sciadv.adp3976
6. [6]
  W. Tang, Y. Fang, L.H. Xie, et al., Adv. Healthc. Mater. 14 (2025) 2405009. doi: 10.1002/adhm.202405009
7. [7]
  Y. Lu, R. Xu, W. Liu, et al., J. Mater. Chem. B 12 (2024) 5111–5127. doi: 10.1039/d4tb00536h
8. [8]
  Z.Y. Liang, W.K. Liu, Z.Q. Wang, et al., Acta Biomater. 143 (2022) 428–444. doi: 10.1016/j.actbio.2022.02.029
9. [9]
  J.J. Zhang, H.Y. Guo, M. Liu, et al., Exploration 4 (2024) 20230087. doi: 10.1002/EXP.20230087
10. [10]
  Y.L. You, X. Yu, J.J. Jiang, et al., Nat. Commun. 16 (2025) 2836. doi: 10.1038/s41467-025-58061-5
11. [11]
  D.Y. Zhao, J.L. Feng, Q.S. Huo, et al., Science 279 (1998) 548–552. doi: 10.1126/science.279.5350.548
12. [12]
  N.Q. Yin, X.L. Wang, T.H. Yang, et al., Ceramics Int. 47 (2021) 8271–8278. doi: 10.1016/j.ceramint.2020.11.188
13. [13]
  Y. Wang, H.C. Gu, Adv. Mater. 27 (2015) 576–585. doi: 10.1002/adma.201401124
14. [14]
  Y. Tao, E.G. Ju, J.S. Ren, et al., Adv. Mater. 27 (2015) 1097–1104. doi: 10.1002/adma.201405105
15. [15]
  C.Y. Cao, W. Ge, J.J. Yin, et al., Small 16 (2020) 2000436. doi: 10.1002/smll.202000436
16. [16]
  Y.J. Xin, Z.Y. Guo, A.J. Ma, et al., Chem. Eng. J. 451 (2023) 138782. doi: 10.1016/j.cej.2022.138782
17. [17]
  T. Niimura, Y. Kurokawa, S. Horiike, et al., Phys. Rev. B 102 (2020) 094411. doi: 10.1103/PhysRevB.102.094411
18. [18]
  H.W. Fan, M.H. Peng, I. Strauss, et al., Nat Commun 12 (2021) 38. doi: 10.4236/jcc.2021.912003
19. [19]
  A. Titova, C. Fowley, E. Clifford, et al., Sci. Rep. 9 (2019) 4020. doi: 10.1038/s41598-019-40609-3
20. [20]
  J.L. Wang, Y.X. Wang, L. Xu, et al., Carbohydr. Polymers 181 (2018) 19–26. doi: 10.3847/1538-4357/aae531
21. [21]
  W.J. Yang, G.L. Huang, J. Mol. Struct. 1285 (2023) 135480. doi: 10.1016/j.molstruc.2023.135480
22. [22]
  G.Y. Qian, Y.W. Li, H.B. Chen, et al., Nat. Commun. 14 (2023) 6048. doi: 10.1038/s41467-023-41867-6
23. [23]
  Q.L. Li, X.B. Zhang, C. Guo, et al., Materials 17 (2024) 1754. doi: 10.3390/ma17081754
24. [24]
  Y. Chen, W. Wei, Y. Zhao, et al., Materials 16 (2023) 7036. doi: 10.3390/ma16217036
25. [25]
  D.C. Niu, Z. Ma, Y.S. Li, et al., J. Am. Chem. Soc. 132 (2010) 15144–15147. doi: 10.1021/ja1070653
26. [26]
  L.M. Qin, D.C. Niu, Y. Jiang, et al., IJN 14 (2019) 1519–1532. doi: 10.2147/ijn.s184192
27. [27]
  T.C. Chou, Pharmacol. Rev. 58 (2006) 621–681. doi: 10.1124/pr.58.3.10
28. [28]
  X.Y. Wang, M. Liu, C.J. Yu, et al., Mol. Biomed. 4 (2023) 49.
29. [29]
  J.G. Li, G.Y. Pan, G.V. Zyryanov, et al., ACS Appl. Mater. Interfaces 15 (2023) 40864–40876. doi: 10.1021/acsami.3c00556
30. [30]
  E.A. Saverina, N.A. Frolov, O.A. Kamanina, et al., ACS Infect. Dis. 9 (2023) 394–422. doi: 10.1021/acsinfecdis.2c00469
1. [1]
  Hongwei Ding , Jingjing Yang , Yongchen Shuai , Di Wei , Xueliang Liu , Guiying Li , Lin Jin , Jianliang Shen . In situ preparation of tannin-mediated CeO₂@CuS nanocomposites for multimodal wound therapy. Chinese Chemical Letters, 2025, 36(6): 110286-. doi: 10.1016/j.cclet.2024.110286
2. [2]
  Mengyao Gao , Shan Sun , Hengwei Lin , Cheng Yang . A multifunctional carbon dot-based nanoplatform for antibacterial therapy: Integrating photodynamic, photothermal, and gas treatments. Chinese Chemical Letters, 2026, 37(2): 111055-. doi: 10.1016/j.cclet.2025.111055
3. [3]
  Zhiqi Hu , Lingling Wu , Duo Zhang , Yixue An , Jiao Wang , Binbin Zhao , Robert Chunhua Zhao , Rong Cao , Xue Yang . Ultrathin transparent metal-organic framework-based nanocomposite membranes for antibacterial wound healing. Chinese Journal of Structural Chemistry, 2025, 44(12): 100749-100749. doi: 10.1016/j.cjsc.2025.100749
4. [4]
  Yang Hong , Qianwei Su , Xiang Wu , Qin Zhang , Jianhua Sun , Yu Wang , Jiacan Su . Biocompatible mesoporous silica: A novel nanomaterial for skin wound healing. Chinese Chemical Letters, 2026, 37(8): 111846-. doi: 10.1016/j.cclet.2025.111846
5. [5]
  Wantong Zhang , Zixing Xu , Guofei Dai , Zhijian Li , Chunhui Deng . Removal of Microcystin-LR in lake water sample by hydrophilic mesoporous silica composites under high-throughput MALDI-TOF MS detection platform. Chinese Chemical Letters, 2024, 35(5): 109135-. doi: 10.1016/j.cclet.2023.109135
6. [6]
  Xu Sun , Mengchen Luo , Xinyu Xie , Mengyao Liu , Weili Wang , Tian Zhang , Lei An , Jinjun Shao , Xiaochen Dong , Yu Cai . Thienothiadiazole-based NIR-Ⅱ D-A-D dye for fluorescence and photoacoustic imaging-navigated photothermal therapy. Chinese Chemical Letters, 2026, 37(6): 111509-. doi: 10.1016/j.cclet.2025.111509
7. [7]
  Haijun Shen , Yi Qiao , Chun Zhang , Yane Ma , Jialing Chen , Yingying Cao , Wenna Zheng . A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing. Chinese Chemical Letters, 2024, 35(12): 110283-. doi: 10.1016/j.cclet.2024.110283
8. [8]
  Feng Cui , Fangman Chen , Xiaochun Xie , Chenyang Guo , Kai Xiao , Ziping Wu , Yinglu Chen , Junna Lu , Feixia Ruan , Chuanxu Cheng , Chao Yang , Dan Shao . Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation. Chinese Chemical Letters, 2024, 35(4): 108681-. doi: 10.1016/j.cclet.2023.108681
9. [9]
  Yuyao Guan , Baoting Yu , Jun Ding , Tingting Sun , Zhigang Xie . BODIPY photosensitizers for antibacterial photodynamic therapy. Chinese Chemical Letters, 2025, 36(8): 110645-. doi: 10.1016/j.cclet.2024.110645
10. [10]
  Shaobo Wang , Honggui Yang , Chunni Zhao , Deyu Hu , Baoan Song . Antibacterial agrochemicals: Recent research progress and outlook. Chinese Chemical Letters, 2026, 37(1): 111543-. doi: 10.1016/j.cclet.2025.111543
11. [11]
  Jiaye Wang , Xiong Yang , Yang Lei , Tianwen Xi , Sijie Wang , Yidan Zhou , Bing Liu , Yu Liu , Hui Yang , Leming Sun . Zinc coordination self-assembly of bacitracin nanoparticles with broadened antibacterial spectrum. Chinese Chemical Letters, 2026, 37(4): 111086-. doi: 10.1016/j.cclet.2025.111086
12. [12]
  Yue Ren , Kang Li , Yi-Zi Wang , Shao-Peng Zhao , Shu-Min Pan , Haojie Fu , Mengfan Jing , Yaming Wang , Fengyuan Yang , Chuntai Liu . Swelling and erosion assisted sustained release of tea polyphenol from antibacterial ultrahigh molecular weight polyethylene for joint replacement. Chinese Chemical Letters, 2025, 36(2): 110468-. doi: 10.1016/j.cclet.2024.110468
13. [13]
  Xicheng Li , Dong Mo , Shoushan Hu , Meng Pan , Meng Wang , Tingyu Yang , Changxing Qu , Yujia Wei , Jianan Li , Hanzhi Deng , Zhongwu Bei , Tianying Luo , Qingya Liu , Yun Yang , Jun Liu , Jun Wang , Zhiyong Qian . A Pt@ZIF-8/ALN-ac/GelMA composite hydrogel with antibacterial, antioxidant, and osteogenesis for periodontitis. Chinese Chemical Letters, 2025, 36(9): 110674-. doi: 10.1016/j.cclet.2024.110674
14. [14]
  Xiangrong Pan , Xixi Hou , Yuhang Du , Zhixin Pang , Shiyang He , Lan Wang , Jianxue Yang , Longfei Mao , Jianhua Qin , Haixia Wu , Baozhong Liu , Zhan Zhou , Lufang Ma , Chaoliang Tan . Solvent-mediated synthesis of 2D In-TCPP MOF nanosheets for enhanced photodynamic antibacterial therapy. Chinese Chemical Letters, 2025, 36(12): 110536-. doi: 10.1016/j.cclet.2024.110536
15. [15]
  Deqi Fan , Yicheng Tang , Yemei Liao , Yan Mi , Yi Lu , Xiaofei Yang . Two birds with one stone: Functionalized wood composites for efficient photocatalytic hydrogen production and solar water evaporation. Chinese Chemical Letters, 2024, 35(9): 109441-. doi: 10.1016/j.cclet.2023.109441
16. [16]
  Yang Liu , Leilei Zhang , Kaixuan Liu , Ling-Ling Wu , Hai-Yu Hu . Penicillin G acylase-responsive near-infrared fluorescent probe: Unravelling biofilm regulation and combating bacterial infections. Chinese Chemical Letters, 2024, 35(11): 109759-. doi: 10.1016/j.cclet.2024.109759
17. [17]
  Xiaoliu Liang , Chunliu Huang , Hui Liu , Hu Chen , Jiabao Shou , Hongwei Cheng , Gang Liu . Natural hydrogel dressings in wound care: Design, advances, and perspectives. Chinese Chemical Letters, 2024, 35(10): 109442-. doi: 10.1016/j.cclet.2023.109442
18. [18]
  Wen Zhong , Dan Zheng , Xukun Liao , Yadi Zhou , Yan Jiang , Ting Gao , Ming Li , Chengli Yang . Elaborate construction of pH-sensitive polymyxin B loaded nanoparticles for safe and effective treatment of carbapenem-resistant Klebsiella pneumoniae. Chinese Chemical Letters, 2025, 36(3): 110448-. doi: 10.1016/j.cclet.2024.110448
19. [19]
  Yueying Wang , Jianming Xiong , Linwei Xin , Yuanyuan Li , He Huang , Wenjun Miao . Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing. Chinese Chemical Letters, 2025, 36(4): 110003-. doi: 10.1016/j.cclet.2024.110003
20. [20]
  Ruijun Song , Huixu Xie , Guiting Liu . Advances of MXene-based hydrogels for chronic wound healing. Chinese Chemical Letters, 2025, 36(7): 110442-. doi: 10.1016/j.cclet.2024.110442

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(18)
HTML views(0)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142