Citation: Yang Hong, Qianwei Su, Xiang Wu, Qin Zhang, Jianhua Sun, Yu Wang, Jiacan Su. Biocompatible mesoporous silica: A novel nanomaterial for skin wound healing[J]. Chinese Chemical Letters, ;2026, 37(8): 111846. doi: 10.1016/j.cclet.2025.111846 shu

Biocompatible mesoporous silica: A novel nanomaterial for skin wound healing

Yang Hong ^{a, b, c, d, 1} ,
Qianwei Su ^{e, 1} ,
Xiang Wu ^{a, b, c, d, 1} ,
Qin Zhang ^{a, b, c, *,} ,
Jianhua Sun ^f ,
Yu Wang ^{f, *,} ,
Jiacan Su ^{a, b, c, g, *,}

a.
Institute of Translational Medicine, Shanghai University, Shanghai 200444, China
b.
MedEng-X Institutes, Shanghai University, Shanghai 200444, China
c.
National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China
d.
School of Medicine, Shanghai University, Shanghai 200444, China
e.
Department of Polymer Science and Engineering, ERC of Membrane and Water Treatment (MOE), Key Laboratory of Macromolecular Synthesis and Functionalization (MOE), Zhejiang University, Hangzhou 310058, China
f.
Department of Cardiology, Shidong Hospital, Shanghai 200438, China
g.
Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

sabrina_1985@shu.edu.cn

wangyushidonghos@163.com

drsujiacan@163.com

Received Date: 28 July 2025
Revised Date: 12 September 2025
Accepted Date: 16 September 2025
Available Online: 17 September 2025

Figures(10)

Chronic cutaneous wounds such as diabetic foot and pressure ulcers are increasing worldwide and remain difficult to manage. Conventional approaches are hindered by prolonged healing and antibiotic resistance, highlighting the need for advanced biomaterial strategies. Thus, the production of advanced biomaterials for efficient wound healing has become of special urgency. Mesoporous silica (MS), with its specific features of exceptional biocompatibility, easily tunable pore architectures, and multifunctional surface functionalization, has emerged as a promising choice in such applications. The review systematically overviews the most recent advances in the wound healing application of MS, with its participation in drug delivery, controlled inflammation, modulation of immune response, tissue regeneration, and angiogenesis. Synthesis methods, surface functionalization techniques, and incorporation of advanced technology such as stimulus responsive systems and multifunctional composites are also extensively reviewed. Furthermore, this review critically examines the key barriers to the clinical translation of MS, including long-term biosafety, immune compatibility, and scalable manufacturing. Overcoming these challenges is crucial for harnessing its full potential in next-generation wound healing. By integrating MS with precision medicine and emerging biomedical technologies, this review highlights its transformative role in advancing personalized wound care and regenerative medicine.
- Mesoporous silica,
- Wound healing,
- Tissue regeneration,
- Precision medicine,
- Surface functionalization
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沈阳化工大学材料科学与工程学院沈阳 110142