Citation: Jing Qian, Guoxing Ling, Yue Li, Yan Liu, Xiaoxuan Guan, Zuyuan Huang, Ming Gao, Cheng Luo, Baoshi Zheng. Research progress on nanobiomedicine targeting mitochondrial homeostasis for improving myocardial ischemia[J]. Chinese Chemical Letters, ;2026, 37(5): 111843. doi: 10.1016/j.cclet.2025.111843 shu

Research progress on nanobiomedicine targeting mitochondrial homeostasis for improving myocardial ischemia

Jing Qian ^{a, 1} ,
Guoxing Ling ^{b, 1} ,
Yue Li ^{b, 1} ,
Yan Liu ^c ,
Xiaoxuan Guan ^d ,
Zuyuan Huang ^b ,
Ming Gao ^d ,
Cheng Luo ^{b, *,} ,
Baoshi Zheng ^{b, *,}

a.
Cardiothoracic Surgery Intensive Care Unit, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
b.
Department of Cardiothoracic Surgery, Cardiovascular Injury and Repair Engineering Research Center of Guangxi Department of Education, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
c.
Department of Nutrition, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
d.
Life Sciences Institute, Guangxi Medical University, Nanning 530021, China

drluocheng@163.com

baoshizhengyx@163.com

Received Date: 14 July 2025
Revised Date: 13 September 2025
Accepted Date: 16 September 2025
Available Online: 16 September 2025

Figures(3)

Myocardial infarction (MI) is a disease with a very high mortality rate among cardiovascular diseases. It causes extensive damage to myocardial cells due to prolonged and repeated ischemia and hypoxia. Early coronary revascularization is the best method for treating MI. However, the reperfusion process in MI can produce reactive oxygen species, further damaging myocardial tissue, and triggering MI-reperfusion injury (MI/RI). Although various traditional treatment strategies exist, the treatment of myocardial ischemia including MI and MI/RI remain a significant challenge. Mitochondrial dysfunction plays an important role in the emergence and development of myocardial ischemia. In recent years, with the advancement of nanobiomedicine, therapeutic strategies for targeting mitochondria have gained increasing attentions in diseases' therapy. Thus, nanobiomedicine targeting mitochondria has shown great promise in the treatment of myocardial ischemia. This review first comprehensively elaborates on the mechanisms of mitochondrial homeostasis in MI and MI/RI, and then focuses on the application progress of nanomaterials targeting mitochondrial homeostasis (oxidative stress, mitophagy, mitochondrial fusion and fission, etc.) in improving myocardial ischemia. Ultimately, this article looks forward to the prospects of nanomaterials in the targeting treatment of MI and MI/RI, aiming to provide more effective and innovative ideas for clinical treatments.
- Myocardial ischemia,
- Nanobiomedicine,
- Mitochondrial homeostasis,
- Mitophagy,
- Mitochondrial quality control,
- Mitochondrial targeted therapy
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沈阳化工大学材料科学与工程学院沈阳 110142