Citation: Dechao Yuan, Tianying Luo, Qiao Su, Changxing Qu, Meng Pan, Jia Xu, Mingyi Zhang, Yuanchao Luo, Renjian He, Shiwei Liu, Xiang Fang, Hong Duan, Zhiyong Qian. Nanozyme-based catalytic therapeutics: Applications in infectious diseases, cancer therapy, and bone regeneration[J]. Chinese Chemical Letters, ;2026, 37(3): 111842. doi: 10.1016/j.cclet.2025.111842 shu

Nanozyme-based catalytic therapeutics: Applications in infectious diseases, cancer therapy, and bone regeneration

Dechao Yuan ^{b, 1} ,
Tianying Luo ^{a, 1} ,
Qiao Su ^d ,
Changxing Qu ^d ,
Meng Pan ^a ,
Jia Xu ^a ,
Mingyi Zhang ^a ,
Yuanchao Luo ^b ,
Renjian He ^b ,
Shiwei Liu ^b ,
Xiang Fang ^c ,
Hong Duan ^{c, *,} ,
Zhiyong Qian ^{a, *,}

a.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Orthopedics, Zigong First People's Hospital, Zigong 643000, China
c.
Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China
d.
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China

duanhong1970@126.com

anderson-qian@163.com

Received Date: 5 July 2025
Revised Date: 13 September 2025
Accepted Date: 15 September 2025
Available Online: 17 September 2025

Figures(5)

Nanozymes are nanomaterials with enzyme-like catalytic activities that have rapidly advanced in the biomedical field in recent years due to their high stability, low cost, and catalytic versatility. As promising alternatives to natural enzymes, nanozymes have demonstrated unique advantages in infection control, cancer therapy, and tissue regeneration. This review systematically summarizes key advances in recent years in nanozyme-based catalytic therapeutics. We focus on their mechanisms and applications in combating bacterial, viral, and fungal infections via membrane lipid peroxidation, protein/genome damage, and biofilm disruption; in cancer treatment through chemodynamic therapy (CDT), tumor microenvironment modulation, and multimodal synergistic strategies; and in bone regeneration through antioxidant, anti-inflammatory, and osteoinductive functions. Moreover, we highlight the integration of nanozymes with hydrogels, scaffolds, and microrobotic systems to enhance therapeutic outcomes. Finally, current challenges such as targeting specificity, in vivo catalytic control, biosafety, and clinical translation are discussed to provide a comprehensive roadmap for future research and clinical development in catalytic nanomedicine.
- Nanozymes,
- Catalytic therapeutics,
- Infectious diseases,
- Cancer therapy,
- Bone regeneration
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沈阳化工大学材料科学与工程学院沈阳 110142