Citation: Xiaojie Sun, Xiaoyan Yang, Zitong Wang, Furui Qu, Xin Cong, Qingsong Fu, Chang Su, Xiguang Chen, Kai Shao, Zhiyu He, Chao Feng. The micro-nano electrospinning membrane with water repellenting separation effect for interface hemostasis and anti-adhesion[J]. Chinese Chemical Letters, ;2026, 37(8): 111841. doi: 10.1016/j.cclet.2025.111841 shu

The micro-nano electrospinning membrane with water repellenting separation effect for interface hemostasis and anti-adhesion

Xiaojie Sun ^{a, b, 1} ,
Xiaoyan Yang ^{b, 1} ,
Zitong Wang ^a ,
Furui Qu ^a ,
Xin Cong ^b ,
Qingsong Fu ^c ,
Chang Su ^b ,
Xiguang Chen ^{a, b, e} ,
Kai Shao ^{c, d, *,} ,
Zhiyu He ^{f, *,} ,
Chao Feng ^{a, b, *,}

a.
Sanya Oceanographic Institute, Ocean University of China, Sanya 572024, China
b.
College of Marine Life Science, Ocean University of China, Qingdao 266005, China
c.
Laboratory of Cerebrospinal Fluid Cytology and Neuroimmunology, Department of Central Laboratory, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, China
d.
Department of Clinical Laboratory, Qilu Hospital of Shandong University, Ji'nan 250012, China
e.
Laoshan Laboratory, Qingdao 266000, China
f.
Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology (BIT), Zhuhai 519088, China

qlshaokai@163.com

hezhiyu@ouc.edu.cn

fengchao@ouc.edu.cn

Received Date: 4 June 2025
Revised Date: 12 September 2025
Accepted Date: 15 September 2025
Available Online: 16 September 2025

Figures(4)

Rapid hemostasis is a paramount issue in tissue wound repair treatment. Currently, hydrophilic hemostatic materials are favored for their absorption concentration capabilities in achieving swift hemostasis. However, the subsequent adherence of these materials to the wound presents another challenge, impacting the overall therapeutic outcome. Here, we reported a flexible electrospinning membrane (75D-P) composed of polyacrylonitrile (PAN) and diatom biosilica (DB), which integrated the submicron-sized pores of fiber membranes with the hierarchical porous structure of DB. It exhibited weak interfacial hydrophobicity, enabling rapid plasma protein adsorption capacity and accelerating blood coagulation at the material interface. The clotting time of kaolin commercial hemostatic agent-QuikClot^® (QC) was 200 s, and that of 75D-P was 100 s, with the minimum tissue adhesion (0.06 N). Importantly, in the rabbit injury models, the dosage of the 75D-P was far below that of the QC group, yet it maintained comparable clotting time (about 400 s) and blood loss (4 g). We have integrated DB and PAN in electrospinning membrane could achieve a distinct water repellenting separation effect on blood components, promoting efficient interfacial blood coagulation. These offer insights into facilitating the blood clots formation at interfacial, thereby mitigating excessive material blood absorption and tissue adhesion.
- Electrospinning hemostatic,
- Micro-nano structure,
- Water repellenting separation effect,
- Interface hemostasis,
- Anti-adhesion
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