Citation: Yifa Yang, Sheng-Ye Zhang, Yongrui Luo, Jian Wu, Xuebing Leng, Qilong Shen. Unraveling the mechanism of trifluoromethyl group transfer from Cu(Ⅰ) to Cu(Ⅲ)[J]. Chinese Chemical Letters, ;2026, 37(7): 111821. doi: 10.1016/j.cclet.2025.111821 shu

Unraveling the mechanism of trifluoromethyl group transfer from Cu(Ⅰ) to Cu(Ⅲ)

Yifa Yang ^{a, 1} ,
Sheng-Ye Zhang ^{b, 1} ,
Yongrui Luo ^a ,
Jian Wu ^c ,
Xuebing Leng ^b ,
Qilong Shen ^{a, *,}

a.
State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China
b.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China
c.
Instrumental Analysis Center, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

shenql@mail.sioc.ac.cn

Received Date: 5 June 2025
Revised Date: 21 August 2025
Accepted Date: 10 September 2025
Available Online: 16 September 2025

Figures(5)

Mechanistic studies of the transmetalation of the trifluoromethyl group from an ionic Cu(Ⅰ) complex Q⁺[Cu(CF₃)₂]⁻ to a well-defined chlorinated Cu(Ⅲ) complex trans-[Cu(CF₃)₂(Cl)(CH₂CN)]⁻Q⁺ was reported. The combined experimental and computational results including kinetics of the process, reactions in the presence of excess chloride salt, or radical scavengers such as TEMPO or 1, 1-diphenylethene (DPE), 1, 4-dinitrobenzene (DNB), strongly support a concerted metathesis pathway.
- Copper,
- Trifluoromethyl group transfer,
- Transmetalation,
- Mechanism study,
- Organometallics
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