Citation: Chun Yang, Yina Lou, Muran Bai, Yingying Qian, Wenwen Shen, Yucheng Wan, Yang Liu, Qidi Zhao, Haiyu Hu, Yiyuan Tang, Wei Wang, Zhijin Fan, Yuhui Liao. Advances in metal-based nanomedicine: From basic science to clinical implications[J]. Chinese Chemical Letters, ;2026, 37(8): 111817. doi: 10.1016/j.cclet.2025.111817 shu

Advances in metal-based nanomedicine: From basic science to clinical implications

Chun Yang ^{a, 1} ,
Yina Lou ^{a, b, 1} ,
Muran Bai ^{a, 1} ,
Yingying Qian ^a ,
Wenwen Shen ^c ,
Yucheng Wan ^d ,
Yang Liu ^a ,
Qidi Zhao ^a ,
Haiyu Hu ^a ,
Yiyuan Tang ^a ,
Wei Wang ^{b, *,} ,
Zhijin Fan ^{b, *,} ,
Yuhui Liao ^{b, *,}

a.
College of Basic Medicine, Beihua University, Jilin 132033, China
b.
Institute for Engineering Medicine, Kunming Medical University, Kunming 650500, China
c.
Department of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China
d.
Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, China

wangwei1992@smu.edu.cn

fanzhijin@m.scnu.edu.cn

liaoyh8@mail.sysu.edu.cn

Received Date: 13 May 2025
Revised Date: 1 September 2025
Accepted Date: 9 September 2025
Available Online: 10 September 2025

Figures(7)

Metal-based nanomedicine, which involves nanoparticles (NPs) composed of metals such as gold, silver, iron, and platinum, has emerged as a promising approach in drug delivery, cancer therapy, imaging, and diagnostics. This review systematically examines a variety of metal-containing NPs (MNPs), including elemental metal NPs, metal oxides, metal-organic frameworks, nanozymes, and up-conversion NPs, highlighting their unique physicochemical properties and biomedical applications. The biological functions of MNPs, particularly in drug delivery, imaging, and therapeutic contexts, are critically discussed. Key engineering strategies aimed at optimizing targeted delivery, drug loading, responsive release, and biocompatibility are explored, with a focus on enhancing clinical outcomes. Recent advances underscore the potential of MNPs in innovative applications such as liquid biopsy, tumor imaging, chemotherapy, immunotherapy, physical therapy, and nanozyme-mediated treatments. Despite promising developments, clinical translation remains hindered by challenges such as toxicity, scalability, and regulatory hurdles. This review concludes with an outlook on future directions for MNPs, emphasizing their potential to revolutionize disease diagnosis and treatment through innovative biomaterial design and engineering.
- Metal nanomedicine,
- Metal-containing nanoparticles,
- Metal-organic frameworks,
- Drug delivery,
- Targeted therapy,
- Ferroptosis
1. [1]
  X.X. Qi, M. Yao, M. Jin, H.Y. Guo, J. Nanosci. Nanotechnol. 21 (2021) 843–851. doi: 10.1166/jnn.2021.18697
2. [2]
  H.Z. Deng, Y. Qu, B.Y. Chu, et al., Biomaterials 317 (2025) 123072. doi: 10.1016/j.biomaterials.2024.123072
3. [3]
  Y.J. Zhang, W.H. Gao, Y.N. Ma, et al., Nano Today 49 (2023) 101768. doi: 10.1016/j.nantod.2023.101768
4. [4]
  G.Q. Yuan, X.X. Luo, K. He, et al., Sci. Adv. 11 (2025) eadw7032. doi: 10.1126/sciadv.adw7032
5. [5]
  T.S. Lan, D.X. Cui, T.Y. Liu, et al., Nano Biomed. Eng. 15 (2023) 330–341. doi: 10.26599/NBE.2023.9290025
6. [6]
  V.V. Kshatriya, M.R. Kumbhare, S.V. Jadhav, et al., BIOI 5 (2024) 992.
7. [7]
  Q.Y. He, S. Schmidt, W.Q. Zhu, et al., Science 382 (2023) 1065–1069. doi: 10.1126/science.adj2522
8. [8]
  R. Sakthi Devi, A. Girigoswami, M. Siddharth, K. Girigoswami, Appl. Biochem. Biotechnol. 194 (2022) 4187–4219. doi: 10.1007/s12010-022-03963-z
9. [9]
  L. Liu, X.F. An, M. Schaefer, et al., Biomed. Pharmacother. 153 (2022) 113511. doi: 10.1016/j.biopha.2022.113511
10. [10]
  L.X. Zhang, G. Alimu, Z. Du, et al., ACS Omega 8 (2023) 21793–21801. doi: 10.1021/acsomega.3c01374
11. [11]
  D.S. Wei, Y. Huang, B. Wang, et al., Angew. Chem. Int. Ed. 61 (2022) e202201486. doi: 10.1002/anie.202201486
12. [12]
  M. Wang, R. Cai, Z.W. Zhang, et al., J. Nanobiotechnology 22 (2024) 355. doi: 10.1186/s12951-024-02568-4
13. [13]
  N.N. Song, J.L. Zhang, J. Zhai, et al., Acc. Chem. Res. 54 (2021) 3313–3325. doi: 10.1021/acs.accounts.1c00267
14. [14]
  D.A. da Silva, A. De Luca, R. Squitti, et al., J. Inorg. Biochem. 226 (2022) 111634. doi: 10.1016/j.jinorgbio.2021.111634
15. [15]
  S. Samadzadeh, M. Babazadeh, N. Zarghami, et al., Mater. Sci. Eng. C: Mater. Biol. Appl. 118 (2021) 111384. doi: 10.1016/j.msec.2020.111384
16. [16]
  E. Alphandéry, Int. J. Pharm. 586 (2020) 119472. doi: 10.1016/j.ijpharm.2020.119472
17. [17]
  L.S. Ganapathe, M.A. Mohamed, R.M. Yunus, D.D. Berhanuddin, Magnetochemistry 6 (2020) 68. doi: 10.3390/magnetochemistry6040068
18. [18]
  N. Lagopati, K. Evangelou, P. Falaras, et al., Pharmacol. Ther. 222 (2021) 107795. doi: 10.1016/j.pharmthera.2020.107795
19. [19]
  M. Alavi, P. Kamarasu, D.J. McClements, M.D. Moore, Adv. Colloid. Interface Sci. 306 (2022) 102726. doi: 10.1016/j.cis.2022.102726
20. [20]
  S. Tsymbal, G. Li, N. Agadzhanian, et al., Molecules 27 (2022) 7066. doi: 10.3390/molecules27207066
21. [21]
  A. Manuja, B. Kumar, R. Kumar, et al., Toxicol. Rep. 8 (2021) 1970–1978. doi: 10.1016/j.toxrep.2021.11.020
22. [22]
  S. Attarilar, J. Yang, M. Ebrahimi, et al., Front. Bioeng. Biotechnol. 8 (2020) 822. doi: 10.3389/fbioe.2020.00822
23. [23]
  Y.S. Wei, L. Zou, H.F. Wang, et al., Adv. Energy Mater. 12 (2022) 2003970. doi: 10.1002/aenm.202003970
24. [24]
  W.W. Chai, X.C. Chen, J. Liu, et al., Regen. Biomater. 11 (2024) rbad115. doi: 10.1093/rb/rbad115
25. [25]
  X.C. Cai, X.G. Bao, Y.L. Wu, Pharmaceutics 14 (2022) 2641. doi: 10.3390/pharmaceutics14122641
26. [26]
  J.B. Chen, M.S. Li, R.R. Sun, et al., Adv. Funct. Mater. 34 (2024) 2315276. doi: 10.1002/adfm.202315276
27. [27]
  J.G. Qiu, M.A. Tomeh, Y. Jin, et al., J. Colloid. Interface Sci. 642 (2023) 810–819. doi: 10.1016/j.jcis.2023.03.172
28. [28]
  T. Wen, G.L. Quan, B.Y. Niu, et al., Small 17 (2021) e2005064. doi: 10.1002/smll.202005064
29. [29]
  Q.Y. Wang, Y. Yu, Y.X. Chang, et al., ACS Nano 17 (2023) 8483–8498. doi: 10.1021/acsnano.3c00694
30. [30]
  X.X. Yang, Y.L. Chen, P.F. Feng, et al., Mater. Chem. Front. 6 (2022) 680–688. doi: 10.1039/D1QM01512E
31. [31]
  J.H. Patil, J.K. Patel, U.A. Shah, et al., Nano Biomed. Eng. 16 (2024) 285–308. doi: 10.26599/NBE.2024.9290078
32. [32]
  J.H. Li, P.X. Liu, Y. Chen, et al., J. Am. Chem. Soc. 145 (2023) 19707–19714. doi: 10.1021/jacs.3c04831
33. [33]
  X.Y. Zhao, M. Long, X. Huang, Z.H. Zhang, Chem. Eng. J. 503 (2025) 158523. doi: 10.1016/j.cej.2024.158523
34. [34]
  C.Q. Feng, X.Y. Liang, R.R. Fan, et al., MedComm. Biomater. Appl. 3 (2024) e96.
35. [35]
  C.J. Yang, Y.L. Pan, H.L. Yu, et al., Adv. Sci. 10 (2023) e2302109. doi: 10.1002/advs.202302109
36. [36]
  B. Das, J.L. Franco, N. Logan, et al., Nanomicro Lett. 13 (2021) 193.
37. [37]
  S. Fedeli, J. Im, S. Gopalakrishnan, et al., Chem. Soc. Rev. 50 (2021) 13467–13480. doi: 10.1039/D0CS00659A
38. [38]
  M. Zandieh, J. Liu, Adv. Mater. 36 (2024) e2211041. doi: 10.1002/adma.202211041
39. [39]
  W.H. Gao, J.Y. He, L. Chen, et al., Nat. Commun. 14 (2023) 160. doi: 10.1038/s41467-023-35828-2
40. [40]
  X.D. Zhang, X.K. Chen, Y.L. Zhao, Nanomicro Lett. 14 (2022) 95.
41. [41]
  Y.J. Jiang, Z.B. Chen, N. Sui, Z.L. Zhu, J. Am. Chem. Soc. 146 (2024) 7565–7574. doi: 10.1021/jacs.3c13588
42. [42]
  R.F. Zhang, Y.F. Shen, X.Y. Zhou, et al., Nat. Commun. 16 (2025) 890. doi: 10.1038/s41467-025-56134-z
43. [43]
  P.W. Jin, Wang D. D, Y.J. Lu, et al., Adv. Sci. 12 (2025) e2502664. doi: 10.1002/advs.202502664
44. [44]
  W.C. Peng, W.B. Tai, B.W. Li, et al., Nat. Mater. 24 (2025) 637–648. doi: 10.1038/s41563-024-02041-5
45. [45]
  P. Yu, Y.Y. Li, H. Sun, et al., Adv. Mater. 35 (2023) e2303299. doi: 10.1002/adma.202303299
46. [46]
  X. Wang, X.D. Qin, Y. Liu, et al., Adv. Mater. 36 (2024) e2411194. doi: 10.1002/adma.202411194
47. [47]
  J.F. Zou, W.X. Ding, Y. Chen, et al., Carbohydr. Polym. 361 (2025) 123501. doi: 10.1016/j.carbpol.2025.123501
48. [48]
  Y. Cheng, Y.M. Feng, J. Zhao, et al., Angew. Chem. Int. Ed. 64 (2025) e202422375. doi: 10.1002/anie.202422375
49. [49]
  J.S. Bao, J.F. Wang, S.D. Chen, et al., ACS Nano 18 (2024) 9100–9113. doi: 10.1021/acsnano.3c13225
50. [50]
  W. Zhang, Y.L. Lu, Y. Zang, et al., Nanomaterials 11 (2021) 3395. doi: 10.3390/nano11123395
51. [51]
  Y.H. Zhang, X.H. Zhu, J. Zhang, et al., J. Colloid. Interface Sci. 600 (2021) 513–529. doi: 10.1016/j.jcis.2021.05.017
52. [52]
  W. Zhang, Y. Zang, Y.L. Lu, et al., Int. J. Mol. Sci. 23 (2022) 4279. doi: 10.3390/ijms23084279
53. [53]
  C.S.M. Martins, A.P. LaGrow, J.A.V. Prior, ACS Sens. 7 (2022) 1269-1299. doi: 10.1021/acssensors.2c00149
54. [54]
  A.M. Wagner, J.M. Knipe, G. Orive, N.A. Peppas, Acta Biomater. 94 (2019) 44–63. doi: 10.1016/j.actbio.2019.05.022
55. [55]
  O. Martinez-Mora, K. Tirez, F. Beutels, et al., Nanomaterials 13 (2023) 2610. doi: 10.3390/nano13182610
56. [56]
  P. Zeng, L.F. Hang, G.F. Zhang, et al., Small 18 (2022) e2204748. doi: 10.1002/smll.202204748
57. [57]
  Z.W. Yuan, X.X. Liu, J.B. Ling, et al., Biomaterials 287 (2022) 121620. doi: 10.1016/j.biomaterials.2022.121620
58. [58]
  R.P. Dhavale, R.P. Dhavale, M.S. Bhatia, et al., J. Drug. Deliv. Sci. Tec. 81 (2023) 104213. doi: 10.1016/j.jddst.2023.104213
59. [59]
  C. Castro-Hinojosa, S. Del Sol-Fernández, E. Moreno-Antolín, et al., Bioconjug. Chem. 34 (2023) 2275–2292. doi: 10.1021/acs.bioconjchem.3c00417
60. [60]
  T.Y. Wei, R.Z. Zhao, L.J. Fang, et al., Adv. Funct. Mater. 34 (2024) 2311908. doi: 10.1002/adfm.202311908
61. [61]
  X. Han, J. Chen, Z.H. Cheng, S.W. Zhou, Chem. Commun. 61 (2025) 1407–1410. doi: 10.1039/D4CC05933F
62. [62]
  B.C. Hu, X.H. Xiao, P. Chen, et al., Biomaterials 290 (2022) 121811. doi: 10.1016/j.biomaterials.2022.121811
63. [63]
  G.H. Hou, J.M. Qian, M. Guo, et al., J. Colloid. Interface Sci. 628 (2022) 968–983. doi: 10.1016/j.jcis.2022.08.091
64. [64]
  M. Skowicki, S. Tarvirdipour, M. Kraus, et al., Adv. Drug Deliv. Rev. 211 (2024) 115354. doi: 10.1016/j.addr.2024.115354
65. [65]
  L.Q. Li, S.Y. Li, Z.J. Fan, et al., ACS Photonics 9 (2022) 2555–2578. doi: 10.1021/acsphotonics.2c00440
66. [66]
  H.N. Xu, Z.L. Guo, M.J. Li, et al., BIOI 5 (2024) 976.
67. [67]
  Y. Tao, M.Q. Li, J.S. Ren, X.G. Qu, Chem. Soc. Rev. 44 (2015) 8636–8663. doi: 10.1039/C5CS00607D
68. [68]
  H. Cui, Y.Y. Zhao, Q. Wu, et al., Bioact. Mater. 33 (2024) 532–544.
69. [69]
  G. Lin, H.R. Lin, Z. Yuan, G. Liu, BIOI 4 (2023) 70.
70. [70]
  L.X. Cheng, D.M. Sang, F.Y. Zhao, et al., J. Colloid. Interface Sci. 615 (2022) 95–109. doi: 10.1016/j.jcis.2022.01.099
71. [71]
  A. Shakeri-Zadeh, J.W.M. Bulte, Nat. Rev. Bioeng. 3 (2025) 245–260.
72. [72]
  T. Mishchenko, I. Balalaeva, A. Gorokhova, et al., Cell Death. Dis. 13 (2022) 455. doi: 10.1038/s41419-022-04851-4
73. [73]
  Z. Li, W.P. Li, S.P. Jiang, et al., Chin. Chem. Lett. 35 (2024) 109150. doi: 10.1016/j.cclet.2023.109150
74. [74]
  A.S. Chauhan, P. Chand, T.J. Parashar, BIOI 6 (2025) 994.
75. [75]
  Y. Li, W. Li, T.C. Han, et al., Nat. Rev. Mater. 6 (2021) 488–507. doi: 10.1038/s41578-021-00283-2
76. [76]
  R. Tang, X.Y. Yuan, Z. Jia, et al., ACS Appl. Nano Mater. 6 (2023) 11661– 11678. doi: 10.1021/acsanm.3c01650
77. [77]
  Z.Y. Chen, X. Wang, Y.H. Ding, et al., ACS Mater. Lett. 5 (2023) 1237–1244. doi: 10.1021/acsmaterialslett.2c01024
78. [78]
  Y.Z. Tang, X.J. Yu, L.R. He, et al., Nat. Commun. 16 (2025) 860. doi: 10.1038/s41467-025-56110-7
79. [79]
  H.Y. Li, H.L. Zhang, X.F. He, et al., Adv. Mater. 35 (2023) e2211597. doi: 10.1002/adma.202211597
80. [80]
  X.F. Meng, Z.H. Zhang, Y. Qian, et al., Adv. Healthc. Mater. 12 (2023) e2301926. doi: 10.1002/adhm.202301926
81. [81]
  S.M. Wu, C. Xu, Y.W. Zhu, et al., Adv. Funct. Mater. 31 (2021) 2103591. doi: 10.1002/adfm.202103591
82. [82]
  Y. Zhang, D.X. Li, J.S. Tan, et al., Small 17 (2021) e2005739. doi: 10.1002/smll.202005739310456
83. [83]
  Y.J. Li, Y. Dong, X.Y. Zhou, K.L. Fan, MedComm Biomater. Appl. 2 (2023) e36.
84. [84]
  B.Z. Yu, Y.S. Wang, T.J. Bing, et al., Adv. Mater. 36 (2024) e2310456. doi: 10.1002/adma.202310456
85. [85]
  C. Fernández-Paz, S. Rojas, P. Salcedo-Abraira, et al., ACS Appl. Mater. Interfaces 12 (2020) 25676–25682. doi: 10.1021/acsami.0c07356
86. [86]
  S. Haddad, I. Abánades Lázaro, M. Fantham, et al., J. Am. Chem. Soc. 142 (2020) 6661–6674. doi: 10.1021/jacs.0c00188
87. [87]
  M.L. Essa, M.A. El-Kemary, E.M. Ebrahem Saied, et al., Materials 13 (2020) 5397. doi: 10.3390/ma13235397
88. [88]
  Z. Cheng, M.Y. Li, R. Dey, Y.H. Chen, J. Hematol. Oncol. 14 (2021) 85. doi: 10.1186/s13045-021-01096-0
89. [89]
  X.Y. Liang, Y.C. Li, B.L. Guo, et al., Adv. Funct. Mater. 34 (2024) 2314772. doi: 10.1002/adfm.202314772
90. [90]
  F. Sukkar, M. Shafaa, M. El-Nagdy, W. Darwish, Int. J. Nanomed. Vol. 16 (2021) 8309–8321. doi: 10.2147/IJN.S331909
91. [91]
  H.H. Xie, M. Yang, X.L. He, et al., Adv. Sci. 11 (2024) e2306494. doi: 10.1002/advs.202306494
92. [92]
  X.C. Li, Y.H. Liu, J.J. Ke, et al., Adv. Mater. 36 (2024) e2414365. doi: 10.1002/adma.202414365
93. [93]
  Z.Z. Fang, Y.F. Shen, D.Q. Gao, New. J. Chem. 45 (2021) 4534–4544. doi: 10.1039/D0NJ05169A
94. [94]
  C.P. Liu, D.Y. He, L.M. Li, et al., Pharmacol. Res. 183 (2022) 106364. doi: 10.1016/j.phrs.2022.106364
95. [95]
  W.J. Xu, Z.K. Zeng, Y.C. Tang, et al., J. Nanobiotechnology 22 (2024) 798. doi: 10.1186/s12951-024-03050-x
96. [96]
  Y.D. Wang, H.D. Li, J.Y. Lin, et al., Nat. Commun. 16 (2025) 1876. doi: 10.1038/s41467-025-57190-1
97. [97]
  C.W. Zhang, J.G. Zhang, X. Yang, et al., Expert. Opin. Drug Deliv. 19 (2022) 623–640. doi: 10.1080/17425247.2022.2081320
98. [98]
  H.F. Li, P.Y. Wang, C. Wen, Nanomaterials 12 (2022) 2111. doi: 10.3390/nano12122111
99. [99]
  J.G. Lin, W.H. Cai, Q. Peng, et al., Scanning 2021 (2021) 2717921.
100. [100]
  L. Gu, Z.Y. Duan, X. Li, et al., Bioact. Mater. 26 (2023) 102–115.
101. [101]
  F.A. Shah, M. Jolic, C. Micheletti, et al., Bioact. Mater. 19 (2023) 103–114.
102. [102]
  M. Ibrahim, E. Ramadan, N.E. Elsadek, et al., J. Control. Release 351 (2022) 215–230. doi: 10.1016/j.jconrel.2022.09.031
103. [103]
  L. Chen, Z.Y. Zhou, C. Hu, et al., Research 2022 (2022) 9845459.
104. [104]
  H. Kim, Y. Joo, Y.M. Kook, et al., ACS Appl. Mater. Interfaces 14 (2022) 4931–4945. doi: 10.1021/acsami.1c20394
105. [105]
  L.M. Sun, H.M. Liu, Y.Q. Ye, et al., Signal. Transduct. Target. Ther. 8 (2023) 418. doi: 10.1038/s41392-023-01642-x
106. [106]
  R.F. Silveira, A.L. Lima, I.P. Gross, et al., Nanomedicine 19 (2024) 1271–1283. doi: 10.1080/17435889.2024.2359355
107. [107]
  N. Serov, V. Vinogradov, Adv. Drug Deliv. Rev. 184 (2022) 114194. doi: 10.1016/j.addr.2022.114194
108. [108]
  Z.Q. Niu, W.H. Zhao, H. Deng, et al., ACS Nano 18 (2024) 20504–20517. doi: 10.1021/acsnano.4c04943
109. [109]
  K. Almansour, A.S. Alqahtani, Sci. Rep. 15 (2025) 8840. doi: 10.1038/s41598-025-92725-y
110. [110]
  Y.H. Kang, J.H. Kim, Nat. Commun. 15 (2024) 4705. doi: 10.1038/s41467-024-48998-4
111. [111]
  H. Wan, Y. Fang, M. Hu, et al., Adv. Sci. 12 (2025) e2405905. doi: 10.1002/advs.202405905
112. [112]
  H. Mashhadimoslem, M.A. Abdol, P. Karimi, et al., ACS Nano 18 (2024) 23842–23875. doi: 10.1021/acsnano.3c13001
113. [113]
  Y.F. Yue, S.A. Mohamed, N.D. Loh, J. Jiang, ACS Nano 19 (2025) 933–949. doi: 10.1021/acsnano.4c12369
114. [114]
  M.A. Nawaz, R. Blay-Roger, M. Saif, et al., ACS Catal. 14 (2024) 15150–15196. doi: 10.1021/acscatal.4c03941
115. [115]
  X.J. Pei, G.Y. Tao, X. Wu, et al., Analyst 145 (2020) 4111–4123. doi: 10.1039/D0AN00392A
116. [116]
  X.P. Li, Q. Zeng, R.J. Zhang, et al., Chem. Eng. J. 450 (2022) 138210. doi: 10.1016/j.cej.2022.138210
117. [117]
  M.Y. Ding, S.S. Cui, L. Fang, et al., Angew. Chem. Int. Ed. 61 (2022) e202203631. doi: 10.1002/anie.202203631
118. [118]
  P.L. Zhou, H.B. Yu, Y. Zhong, et al., Nanomicro Lett. 12 (2020) 166.
119. [119]
  X.M. Huang, L.Y. Li, Z.X. Chen, et al., Adv. Mater. 35 (2023) e2302431. doi: 10.1002/adma.202302431
120. [120]
  M. Zhu, Z.J. Kuang, F. Xu, et al., ACS Appl. Bio Mater. 6 (2023) 1586–1593. doi: 10.1021/acsabm.3c00001
121. [121]
  A. Loewa, J.J. Feng, S. Hedtrich, Nat. Rev. Bioeng. 1 (2023) 545–559. doi: 10.1038/s44222-023-00063-3
122. [122]
  A.H.I. Khormi, R.M.M. Qohal, A.Y.A. Masrai, et al., Egypt. J. Chem. 67 (2024) 1567–1574. doi: 10.21608/ejchem.2024.337883.10838
123. [123]
  G.B. Wu, J.Y. Dai, Q. Cheng, et al., Nat. Electron. 5 (2022) 808–819. doi: 10.1038/s41928-022-00857-0
124. [124]
  Y. Shakhman, I. Shumilin, D. Harries, J. Colloid. Interface Sci. 629 (2023) 165–172. doi: 10.1016/j.jcis.2022.08.123
125. [125]
  X. Wang, J. Chen, H.B. Shi, MedComm. Biomater. Appl. 4 (2025) e70010.
126. [126]
  K. Roshanbinfar, M. Kolesnik-Gray, M. Angeloni, et al., Adv. Healthc. Mater. 12 (2023) e2202408. doi: 10.1002/adhm.202202408
127. [127]
  Q.L. Wang, T.T. Wang, C. Lio, et al., J. Control. Release 356 (2023) 678–690. doi: 10.1016/j.jconrel.2023.03.008
128. [128]
  J.Y. Qiu, P.Q. Jiang, C.H. Wang, et al., Anal. Chem. 94 (2022) 4720–4728. doi: 10.1021/acs.analchem.1c05061
129. [129]
  A. Alnaimi, A. Al-Hamry, Y. Makableh, et al., Biosensors 12 (2022) 1130. doi: 10.3390/bios12121130
130. [130]
  D. Yuan, J.J. Liu, H.Z. Zhang, et al., Talanta 188 (2018) 218–224. doi: 10.1016/j.talanta.2018.05.086
131. [131]
  P. Kshirsagar, P. Seshacharyulu, S. Muniyan, et al., Nanomedicine 43 (2022) 102566. doi: 10.1016/j.nano.2022.102566
132. [132]
  R.T. Xu, L.X. Ouyang, H.Y. Chen, et al., Biosensors 13 (2023) 474. doi: 10.3390/bios13040474
133. [133]
  R.Y. Yang, P. Zhao, L.Y. Wang, et al., Nat. Biomed. Eng. 8 (2024) 1018–1039.
134. [134]
  L. Huang, J.J. Wan, X. Wei, et al., Nat. Commun. 8 (2017) 220. doi: 10.1038/s41467-017-00220-4
135. [135]
  W.Y. He, K.L. Ai, L.H. Lu, Sci. China Chem. 58 (2015) 753–760. doi: 10.1007/s11426-015-5351-8
136. [136]
  J.Y. Zhan, R. Liu, J.J. Zhang, Chin. J. Anal. Chem. 49 (2021) 1133–1141.
137. [137]
  M. Jouyandeh, S.M. Sajadi, F. Seidi, et al., OpenNano 8 (2022) 100104. doi: 10.1016/j.onano.2022.100104
138. [138]
  Y.F. Meng, D.S. Zhang, X. Chen, et al., ACS Appl. Nano Mater. 3 (2020) 4494–4503. doi: 10.1021/acsanm.0c00581
139. [139]
  Z.A. Chen, Z.H. Li, C.J. Li, et al., Drug Deliv. 29 (2022) 1201–1211. doi: 10.1080/10717544.2022.2059124
140. [140]
  S. Sargazi, U. Laraib, S. Er, et al., Nanomaterials 12 (2022) 1102. doi: 10.3390/nano12071102
141. [141]
  O. Rabin, J. Manuel Perez, J. Grimm, et al., Nat. Mater. 5 (2006) 118–122. doi: 10.1038/nmat1571
142. [142]
  Z.H. Song, T. Liu, H.Q. Lai, et al., ACS Nano 16 (2022) 4379–4396. doi: 10.1021/acsnano.1c10663
143. [143]
  J.X. Luo, J.C. Li, M. Yu, et al., Prog. Biochem. Biophys. 48 (2021) 715–720.
144. [144]
  D. Zhang, Y.X. Zhao, Y.J. Gao, et al., J. Mater. Chem. B 1 (2013) 5100–5107. doi: 10.1039/c3tb20907e
145. [145]
  W. Qin, J. Chandra, M.A.S. Abourehab, et al., Mol. Cancer 22 (2023) 87. doi: 10.1186/s12943-023-01784-0
146. [146]
  H.Z. Ma, X.N. Zhang, L. Liu, et al., Sci. Adv. 9 (2023) eadh7828. doi: 10.1126/sciadv.adh7828
147. [147]
  J.J. Xu, W.C. Zhang, Y.W. Guo, et al., Drug Deliv. 29 (2022) 664–678. doi: 10.1080/10717544.2022.2039804
148. [148]
  J. Zhang, X. Ke, T.Y. Ci, J. Funct. Poly. 34 (2021) 215–229.
149. [149]
  B.T. Li, B.G. Kou, Y.J. Jiang, et al., Cancer Res. 49 (2022) 832–837.
150. [150]
  J.J. Xiang, Y.W. Li, Y.F. Zhang, et al., J. Control. Release 330 (2021) 992–1003. doi: 10.1016/j.jconrel.2020.11.006
151. [151]
  L.H. Su, Q. Wu, L.F. Tan, et al., ACS Appl. Mater. Interfaces 11 (2019) 10520–10531. doi: 10.1021/acsami.8b22177
152. [152]
  B.Q. Zhou, J.X. Liu, L. Wang, et al., Nanoscale 14 (2022) 4588–4594. doi: 10.1039/D1NR07750C
153. [153]
  L. Chen, L.L. Zhou, C.H. Wang, et al., Adv. Mater. 31 (2019) e1904997. doi: 10.1002/adma.201904997
154. [154]
  S. Chen, R.Q. Zhao, X.Y. Sun, et al., Adv. Healthc. Mater. 12 (2023) e2201924. doi: 10.1002/adhm.202201924
155. [155]
  T. Asao, G.C. Tobias, S. Lucotti, et al., ExtraCell Vesicles. Circ. Nucl. Acids 4 (2023) 461–485. doi: 10.20517/evcna.2023.37
156. [156]
  Y.D. Wang, F.C. Gao, X.F. Li, et al., J. Nanobiotechnology 20 (2022) 69. doi: 10.1186/s12951-022-01278-z
157. [157]
  C.Y. Cao, X.R. Wang, N. Yang, et al., Chem. Sci. 13 (2022) 863–889. doi: 10.1039/D1SC05482A
158. [158]
  D.G. Liang, Y. Feng, F. Zandkarimi, et al., Cell 186 (2023) 2748–2764 e22. doi: 10.1016/j.cell.2023.05.003
159. [159]
  W.T. Chen, F.F. Hu, Q. Gao, et al., J. Nanobiotechnology 22 (2024) 98. doi: 10.1186/s12951-024-02308-8
160. [160]
  W.F. Song, J.Y. Zeng, P. Ji, et al., Small 19 (2023) e2301148. doi: 10.1002/smll.202301148
161. [161]
  Y. Liu, S.Y. Chi, Y. Cao, Z.H. Liu, ACS Appl. Nano Mater. 5 (2022) 2592–2602. doi: 10.1021/acsanm.1c04277
162. [162]
  F.L. Gao, M.M. Sun, J. Zhang, et al., J. Colloid. Interface Sci. 616 (2022) 369–378. doi: 10.1016/j.jcis.2022.02.060
163. [163]
  S. Khan, M. Sharifi, A. Hasan, et al., J. Adv. Res. 30 (2021) 171–184. doi: 10.1016/j.jare.2020.12.001
164. [164]
  Z.L. Li, H. Wu, J.Q. Zhu, et al., Small Sci. 2 (2022) 2200024. doi: 10.1002/smsc.202200024
165. [165]
  H.T. Sun, Y.Y. Zhang, S.Y. Chen, et al., ACS Appl. Mater. Interfaces 12 (2020) 30145–30154. doi: 10.1021/acsami.0c07013
166. [166]
  W. Ma, H.L. Zhang, S.Y. Li, et al., ACS Biomater. Sci. Eng. 8 (2022) 1354–1366. doi: 10.1021/acsbiomaterials.1c01605
167. [167]
  M.Y. Zhao, R.G. Yang, Y.R. Wei, et al., Nano Today 44 (2022) 101493. doi: 10.1016/j.nantod.2022.101493
168. [168]
  P. Ji, P. Wang, H. Chen, et al., Pharmaceuticals 16 (2023) 234. doi: 10.3390/ph16020234
169. [169]
  Y.X. Wang, J. Chen, R.M. Duan, et al., Adv. Mater. 34 (2022) e2109726. doi: 10.1002/adma.202109726
170. [170]
  N. Li, Q.Q. Sun, Z.Z. Yu, et al., ACS Nano 12 (2018) 5197–5206. doi: 10.1021/acsnano.7b06870
171. [171]
  X. Sun, Z.Y. Zhang, C.B. Xiang, et al., Nano Biomed. Eng. 17 (2025) 248–262. doi: 10.26599/NBE.2025.9290120
172. [172]
  R.A. Mustafa, M.X. Ran, Y.H. Wang, et al., Smart Mater. Med. 4 (2022) 199–211.
173. [173]
  L.L. Zhang, X.Q. Qian, Y.Y. Yang, et al., Nano Biomed. Eng. 17 (2025) 277–286. doi: 10.26599/NBE.2024.9290105
174. [174]
  W.J. Jin, Z.L. Chen, Y. Wang, et al., Chin. Chem. Lett. 35 (2024) 109328. doi: 10.1016/j.cclet.2023.109328
175. [175]
  N. Guo, Y. Xia, Y.X. Duan, et al., Chin. Chem. Lett. 34 (2023) 107542. doi: 10.1016/j.cclet.2022.05.056
176. [176]
  E. Choi, M. Landry, N. Pennock, et al., Adv. Healthc. Mater. 12 (2023) e2202830. doi: 10.1002/adhm.202202830
177. [177]
  S.P. Tang, L. Zhou, H.Y. He, et al., Biomaterials 288 (2022) 121706. doi: 10.1016/j.biomaterials.2022.121706
178. [178]
  T. Liu, M. Zhu, X.W. Chang, et al., Adv. Mater. 35 (2023) e2300086. doi: 10.1002/adma.202300086
179. [179]
  S.M. Wang, Q.Y. Guo, R.B. Xu, et al., J. Nanobiotechnology 21 (2023) 383. doi: 10.1186/s12951-023-02146-0
180. [180]
  J. Huang, Z.C. Xiao, M.Z. Lin, et al., Nano Today 54 (2024) 102102. doi: 10.1016/j.nantod.2023.102102
181. [181]
  Y. Liu, P. Maccarini, G.M. Palmer, et al., Sci. Rep. 7 (2017) 8606. doi: 10.1038/s41598-017-09116-1
182. [182]
  H.R. Wang, J. Meng, J.J. Lin, et al., Nat. Commun. 15 (2024) 4362. doi: 10.1038/s41467-024-48710-6
183. [183]
  Z.J. Fan, S.C. Wu, H.P. Deng, et al., ACS Nano 18 (2024) 12261–12275. doi: 10.1021/acsnano.4c00844
184. [184]
  P.P. Xue, H.L. Zhuang, T.J. Bai, et al., J. Nanobiotechnology 22 (2024) 228. doi: 10.1186/s12951-024-02508-2
185. [185]
  F. Liu, L. Lin, Y. Zhang, et al., Adv. Mater. 31 (2019) e1902885. doi: 10.1002/adma.201902885
186. [186]
  Y.L. Zhu, R.X. Zhao, L.L. Feng, et al., ACS Nano 17 (2023) 6833–6848. doi: 10.1021/acsnano.3c00423
187. [187]
  Z.Y. Hu, J. Shan, X. Jin, et al., ACS Nano 18 (2024) 24327–24349. doi: 10.1021/acsnano.4c06565
188. [188]
  W.Q. Wang, Y.Y. Cui, X.L. Wei, et al., ACS Nano 18 (2024) 15845–15863. doi: 10.1021/acsnano.4c02825
189. [189]
  X.T. Feng, Z.W. Luo, W. Zhang, et al., Adv. Funct. Mater. 35 (2025) 2506476. doi: 10.1002/adfm.202506476
190. [190]
  Y.W. Sun, W. Zhang, Z.W. Luo, et al., Adv. Funct. Mater. 35 (2024) 2415778.
191. [191]
  Y.L. Huang, X.F. Wan, Q. Su, et al., Nat. Commun. 15 (2024) 1643. doi: 10.1038/s41467-024-45619-y
192. [192]
  J.H. Zhang, T. Zhang, Z.J. Zhang, et al., Adv. Funct. Mater. 34 (2024) 2404658. doi: 10.1002/adfm.202404658
193. [193]
  J.J. Zhang, B.Q. Gao, B.L. Ye, et al., Adv. Mater. 35 (2023) e2208571. doi: 10.1002/adma.202208571
194. [194]
  M.S. Dargusch, N. Soro, A.G. Dmeir, et al., Smart Mater. Med. 5 (2023) 127–139.
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沈阳化工大学材料科学与工程学院沈阳 110142